JNc-440 |
| Catalog No.GC65006 |
JNc-440 is a potent antihypertensive agent.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1119503-63-7
Sample solution is provided at 25 µL, 10mM.
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JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1].
JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure[1].
[1]. He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9(11):1491-1503.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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