GLPBio

JAK/STAT Signaling

Research Areas

Products Related to JAK/STAT Signaling(493)

  • GC17473 structure
    GC17473Pelitinib (EKB-569)
    CAS: 257933-82-7
    Purity: >98.00%

    Pelitinib (EKB-569) (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.

  • GC17530 structure
    GC17530OSI-420
    CAS: 183320-51-6
    Purity: >98.50%

    OSI-420 (OSI-420) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor.

  • GC17647 structure
    GC17647AG-18 (Tyrphostin 23)
    CAS: 118409-57-7
    Purity: >98.50%

    AG-18 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.

  • GC17982 structure
    GC17982Icotinib
    CAS: 610798-31-7
    Purity: >98.00%

    Icotinib is an epidermal growth factor receptor (EGFR; IC₅₀=5nM) inhibitor that targets mutants such as EGFR (L858R, T790M, L861Q).

  • GC19408 structure
    GC19408FM381
    CAS: 2226521-65-7
    Purity: >98.00%

    FM-381 is a highly potent and JAK3-selective janus kinase (JAK) inhibitor

  • GB62277 structure
    GB62277iJak-381
    CAS: 1831144-46-7
    Purity: >97.00%

    iJAK-381 is a novel, small-molecule inhibitor selectively targeting the Janus kinase (JAK) family, including JAK1, JAK2, JAK3 and TYK with IC 50 values of 8.52, 53.4, 5998 and 240nM respectively at 1mM ATP.

  • GC10217 structure
    GC10217RG-14620
    CAS: 136831-49-7
    Purity: >99.50%

    inhibitor of epidermal growth factor (EGF) receptor kinase

  • GC10250 structure
    GC10250Mubritinib (TAK 165)
    CAS: 366017-09-6
    Purity: >99.50%

    Mubritinib (TAK 165) is a potent, selective inhibitor of HER2/ErbB2 with IC 50 of 6nM.

  • GC10341 structure
    GC10341Peficitinb (ASP015K, JNJ-54781532)
    CAS: 944118-01-8
    Purity: >98.00%

    Peficitinb (ASP015K, JNJ-54781532) (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.

  • GC10439 structure
    GC10439APTSTAT3-9R
    Purity: >98%

    STAT3 inhibitor

  • GC10643 structure
    GC10643Pimozide
    CAS: 2062-78-4
    Purity: >98.00%

    Pimozide is a chemically novel, highly potent and orally long-acting neuroleptic dopamine receptors inhibitor, with K i s of 2.4nM, 0.2nM and 1.8nM for dopamine D2, D3 and D4 receptors, respectively.

  • GC10889 structure
    GC10889Artesunate
    CAS: 88495-63-0
    Purity: >98.00%

    Artesunate is an antimalarial compound and an inhibitor of signal transducer and activator of transcription 3 (STAT-3) and membrane glutathione S-transferase (EXP1).

  • GC11172 structure
    GC11172TAK-285
    CAS: 871026-44-7
    Purity: >98.00%

    HER2/EGFR(HER1) inhibitor

  • GC11209 structure
    GC11209Cerdulatinib (PRT062070)
    CAS: 1198300-79-6
    Purity: >99.50%

    Cerdulatinib (PRT062070) (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively.

  • GC11264 structure
    GC11264CNX-2006
    CAS: 1375465-09-0
    Purity: >99.50%

    mutant-EGFR inhibitor, selective and irreversible

  • GC11474 structure
    GC11474Napabucasin
    CAS: 83280-65-3
    Purity: >99.00%

    STAT3 inhibitor

  • GC11652 structure
    GC11652CHZ868
    CAS: 1895895-38-1
    Purity: >99.00%

    Type II JAK2 inhibitor

  • GC11744 structure
    GC11744AG 555
    CAS: 133550-34-2
    Purity: >98.00%

    Potent EGFR-kinase inhibitor

  • GC12038 structure
    GC12038RG 13022
    CAS: 136831-48-6
    Purity: >98%

    EGFR tyrosine kinase inhibitor

  • GC12138 structure
    GC121385,15-DPP
    CAS: 22112-89-6
    Purity: >95.00%

    5,15-DPP (5,15-DPP) is a selective STAT3-SH2 antagonist (IC50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively).

  • GC12281 structure
    GC12281EAI045
    CAS: 1942114-09-1
    Purity: >98.50%

    Inhibitor of L858R/T790M EGFR mutants

  • GC12359 structure
    GC12359Hispidulin
    CAS: 1447-88-7
    Purity: >98.00%

    Hispidulin is a flavonoid compound that acts as a Pim-1 inhibitor (IC₅₀=2.71μM).

  • GC12578 structure
    GC12578(R)-Lisofylline
    CAS: 100324-81-0
    Purity: >98.00%

    (R)-Lisofylline is a small molecule compound with anti-inflammatory properties, acting as a lysophosphatidic acid acyltransferase inhibitor (IC₅₀ = 0.6μM).

  • GC12712 structure
    GC12712NT157
    CAS: 1384426-12-3
    Purity: >98%

    NT157 is a selective inhibitor of insulin receptor substrate-1/-2 (IRS-1/2).