JAK/STAT Signaling

STAT6-IN-9 is a potent STAT6 inhibitor with an EC 50 value of 4 nM.

ortho-Topolin riboside is a naturally occurring cytokinin secreted from Populus x robusta leaves after sunrise.

ZDZ-553 is an orally active STAT1 inhibitor with an IC 50 value of 0.87 μM.

STAT6-IN-10 is a STAT6 (signal transducer and activator of transcription 6) inhibitor with an EC 50 of 2 nM.

S3I-1757 is a STAT3 inhibitor.

STAT6-IN-8 is a STAT6 inhibitor with an IC 50 of 0.45 μmol/L.

INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR ( K D = 1.75 nM for mutCALR del52; K D = 6.78 nM for mutCALR ins5 ).

KZ-02 is an orally active dual MEK1 / Pim-1 kinase inhibitor, with an IC 50 of 1.07 nM against MEK1 and an IC 50 of 1.34 μM against Pim-1.

ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.

Firmonertinib-d 3 (Alflutinib-d 3 ) mesylate is the deuterium labeled Firmonertinib mesylate.

PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.

JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.

PROTAC STAT6 degrader-3 is a potent STAT6 PROTAC degrader with a DC 50 of less than 1 nM.

PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC 50 of 20 nM against PDGFRA, a K i of 93.3 nM against CA IX, and a K i of 80.0 nM against CA XII.

Rolditamig (TQB2102 Antibody) is a recombinant humanized anti-human epidermal growth factor receptor 2 ( HER2 ) antibody.

TAVO101 is a humanized anti- TSLP antibody with an EC 50 of 0.19 nM against hTSLP.

Vadalentamig is a human-derived bispecific antibody targeting NKG2D/CD314 & ERBB1/EGFR/HER1 [1] .

iAfaPhos1 is a FKBP12F36V epimer ligand.

8-Epixanthatin is a light-induced growth inhibitor that regulates the phototropic curvature in sunflower hypocotyls.

Diosgenin is a naturally occurring steroidal sapogenin that can inhibit the STAT3 signaling pathway and acts as an activator of Pdia3/ERp57, possessing a variety of important pharmacological activities.

Saikosaponin D is a triterpenoid saponin derivative with antioxidant, antipyretic, and anti-inflammatory properties.

Vitexicarpin (Casticin), a non-isotopic tetramethoxyflavone with three phenyl rings, is a phosphatidylinositol 3-kinase (PI3K) inhibitor with high cytotoxicity.