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phosphatases

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Products Related to phosphatases(102)

  • GC38916 structure
    GC38916GNF362
    CAS: 1003019-41-7
    Purity: >99.00%

    GNF362 is a selective, potent, and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb) with an IC50 of 9 nM.

  • GC38919 structure
    GC38919KY-226
    CAS: 1621673-53-7
    Purity: >98.00%

    KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity.

  • GC39160 structure
    GC39160BCI-215
    CAS: 1245792-67-9
    Purity: >98.00%

    BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells.

  • GC39514 structure
    GC39514TNO155
    CAS: 1801765-04-7
    Purity: >99.00%

    TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 μM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.

  • GC41305 structure
    GC41305DA-3003-2
    CAS: 383907-47-9
    Purity: >98.00%

    Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers.

  • GC41443 structure
    GC41443TAN 1364B
    CAS: 154639-24-4
    Purity: >95.00%

    TAN 1364B, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. TAN 1364B inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively.

  • GC44226 structure
    GC44226MLS-0322825 Cmpd 23
    CAS: 1908414-82-3
    Purity: >98.00%

    MLS-0322825 Cmpd 23 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.

  • GC44637 structure
    GC44637PHPS1
    CAS: 314291-83-3
    Purity: >98.00%

    PHPS1 is a cell permeability, phosphotyrosine analog that selectively inhibits Src-homodomain-containing phosphatases (SHP2) with an IC 50 value of 2.1μM and a K i value of 0.73μM.

  • GC44774 structure
    GC44774PTP Inhibitor III
    CAS: 29936-81-0
    Purity: >95.00%

    PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs).

  • GC44775 structure
    GC44775PTP1B Inhibitor
    CAS: 765317-72-4
    Purity: >98.00%

    PTP1B Inhibitor is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM.

  • GC44887 structure
    GC44887SHP099
    CAS: 1801747-42-1
    Purity: >99.50%

    SHP099 is a highly potent, selective, orally bioavailable SHP2 inhibitor, with an IC 50 value of 0.071μM.

  • GC45149 structure
    GC45149VK3-OCH3
    CAS: 255906-59-3
    Purity: >98.00%

    VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro.

  • GC46011 structure
    GC46011SPI 112
    CAS: 1051387-90-6
    Purity: >98.00%

    A cell-impermeable SHP-2 inhibitor

  • GC46897 structure
    GC46897AUTEN-99
    CAS: 1049780-58-6
    Purity: >98.00%

    AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14).

  • GC47674 structure
    GC47674Mifepristone-d3
    Purity: >99.00%

    A neuropeptide with diverse biological activities

  • GC48509 structure
    GC48509Apigenin 7-O-Glucuronide (hydrate)
    Purity: >95.00%
  • GC49074 structure
    GC49074Forphenicine
    CAS: 57784-96-0
    Purity: >90.00%

    A bacterial metabolite and an inhibitor of alkaline phosphatase

  • GC49169 structure
    GC491693,8’-Biapigenin
    CAS: 101140-06-1
    Purity: >98.00%

    A biflavonoid with diverse biological activities

  • GC49401 structure
    GC49401Triptolide-d3
    Purity: >99.00%

    An internal standard for the quantification of triptolide

  • GC49403 structure
    GC49403Benzarone
    CAS: 1477-19-6
    Purity: >98.00%

    An active metabolite of benzbromarone

  • GC49494 structure
    GC494944-Aminobenzylphosphonic Acid
    CAS: 5424-27-1
    Purity: >95.00%

    An alkaline phosphatase inhibitor

  • GC50041 structure
    GC50041VO-OHpic
    CAS: 675848-25-6
    Purity: >98%

    Potent PTEN inhibitor

  • GC50357 structure
    GC50357CX08005
    CAS: 1256341-22-6
    Purity: >98%

    Competitive PTP1B inhibitor

  • GC50568 structure
    GC50568PHPS1 sodium salt
    Purity: >98%

    Shp2 (PTPN11) inhibitor