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phosphatases

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Products Related to phosphatases(102)

  • GC17995 structure
    GC17995Tacrolimus monohydrate
    CAS: 109581-93-3
    Purity: >99.90%

    immunosuppressive drug

  • GC18106 structure
    GC18106Calyculin A
    CAS: 101932-71-2
    Purity: >95.00%

    Calyculin A is a potent inhibitors of protein phosphatases 1 (PP1) and phosphatases 2A (PP2A), with IC 50 values of 2nM and 0.5–1.0nM, respectively.

  • GC18239 structure
    GC18239TPI-1
    CAS: 79756-69-7
    Purity: >98.00%

    TPI-1 (tyrosine phosphatase inhibitor 1) is a SHP-1 inhibitor (IC 50 = 40nM) and can be used to study melanomas.

  • GC18258 structure
    GC18258CpdA
    CAS: 14593-25-0
    Purity: >98.50%

    CpdA is a non-steroidal selective glucocorticoid receptor modulator.

  • GC18575 structure
    GC185752-hydroxy Tricosanoic Acid methyl ester
    CAS: 118745-41-8
    Purity: >98%

    2-hydroxy Tricosanoic acid methyl ester is a hydroxylated fatty acid methyl ester that has been found in ripe and unripe strawberry homogenates, Pseudosuberites and S.

  • GC18718 structure
    GC18718bpV(pic) (potassium hydrate)
    CAS: 148556-27-8
    Purity: >96.00%

    bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM).

  • GC18859 structure
    GC18859Microcystin-LA
    CAS: 96180-79-9
    Purity: >98%

    Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.

  • GC19223 structure
    GC19223LMPTP INHIBITOR 1 dihydrochloride
    CAS: 2310135-46-5
    Purity: >99.50%

    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 uM LMPTP-A.

  • GC19331 structure
    GC19331SHP099 hydrochloride
    CAS: 1801747-11-4
    Purity: >99.50%

    SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.

  • GC19775 structure
    GC19775M2N12
    CAS: 2376577-06-7
    Purity: >98.00%

    M2N12

  • GC19921 structure
    GC19921Phenylarsine Oxide
    CAS: 637-03-6
    Purity: >98.00%
  • GC30664 structure
    GC30664Enocyanin
    CAS: 11029-12-2
    Purity: >98%

    Enocyanin is an anthocyanin extracted from grapes.

  • GC30754 structure
    GC30754SHP2 IN-1
    CAS: 1801764-90-8
    Purity: >98%

    SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.

  • GC30834 structure
    GC30834Rilapladib (SB 659032)
    CAS: 412950-08-4
    Purity: >99.50%

    Rilapladib (SB 659032) (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM.

  • GC31324 structure
    GC31324PTP1B-IN-2
    CAS: 1919853-46-5
    Purity: >99.50%

    PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.

  • GC31499 structure
    GC31499JTT 551
    CAS: 776309-04-7
    Purity: >98%

    JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

  • GC31635 structure
    GC31635PTP1B-IN-3
    CAS: 809272-64-8
    Purity: >98%

    PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP.

  • GC31772 structure
    GC31772Tautomycin
    CAS: 109946-35-2
    Purity: >98.00%

    Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively.

  • GC32396 structure
    GC32396MSI-1436 (Trodusquemine)
    CAS: 186139-09-3
    Purity: >95.00%

    MSI-1436 (Trodusquemine) is a selective non-competitive inhibitor of the enzyme protein tyrosine phosphatase 1B (PTB1B).

  • GC32397 structure
    GC32397MSI-1436 lactate (Trodusquemine lactate)
    CAS: 1309370-86-2
    Purity: >95.00%

    MSI-1436 lactate (Trodusquemine lactate) is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).

  • GC32709 structure
    GC32709Stibogluconate sodium (Sodium stibogluconate)
    CAS: 16037-91-5
    Purity: >98.00%

    Stibogluconate sodium (Sodium stibogluconate) (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Stibogluconate sodium (Sodium stibogluconate) inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.

  • GC32783 structure
    GC32783Rosiptor (AQX-1125)
    CAS: 782487-28-9
    Purity: >98.00%

    Rosiptor (AQX-1125) (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

  • GC32852 structure
    GC32852LTV-1
    CAS: 347379-29-7
    Purity: >98.00%

    LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.

  • GC33044 structure
    GC33044RMC-4550
    CAS: 2172651-73-7
    Purity: >99.00%

    RMC-4550 is an orally active allosteric inhibitor of SHP2 (IC₅₀=0.583nM).