3,8’-Biapigenin (Synonyms: I3,II8-Biapigenin, 3,8\-Biapigenin) |
| Catalog No.GC49169 |
A biflavonoid with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 101140-06-1
Sample solution is provided at 25 µL, 10mM.
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3,8’-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities.1,2,3,4,5 It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM.2 3,8’-Biapigenin inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively).3 It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 µM.4 3,8’-Biapigenin (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin in rats.5
1.Weng, J.-K., and Noel, J.P.Chemodiversity in Selaginella: A reference system for parallel and convergent metabolic evolution in terrestrial plantsFront. Plant Sci.4119(2013) 2.Nguyen, P.-H., Ji, D.-J., Han, Y.-R., et al.Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effectsBioorg. Med. Chem.23(13)3730-3737(2015) 3.Obach, R.S.Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depressionJ. Pharmacol. Exp. Ther.294(1)88-95(2000) 4.Silva, B., Oliveira, P.J., Dias, A.S., et al.Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insultsNeurotox. Res.13(3-4)265-279(2008) 5.Zduni?, G., Go?evac, D., Milenkovi?, M., et al.Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in ratsPhytother. Res.23(11)1559-1564(2009)
| Cas No. | 101140-06-1 | SDF | |
| Synonyms | I3,II8-Biapigenin, 3,8\-Biapigenin | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=C(C5=CC=C(O)C=C5)OC6=C(C(O)=CC(O)=C6)C4=O | ||
| Formula | C30H18O10 | M.Wt | 538.5 |
| Solubility | DMSO : 50 mg/mL (92.86 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.857 mL | 9.2851 mL | 18.5701 mL |
| 5 mM | 0.3714 mL | 1.857 mL | 3.714 mL |
| 10 mM | 0.1857 mL | 0.9285 mL | 1.857 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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