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Caspase

Caspase - Proteases - Signaling Pathways | GlpBio

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Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products Related to Caspase(168)

  • GC68621 structure
    GC68621Ac-WEHD-AFC TFA
    Purity: >98.00%

    Ac-WEHD-AFC TFA is a fluorescent substrate for caspase-1. It can detect the fluorescence activity of caspase-1 and is used in research on tumors and inflammation.

  • GC68787 structure
    GC68787Boc-Asp(OMe)-fluoromethyl ketone
    CAS: 187389-53-3
    Purity: >98%

    Boc-Asp(OME)-Fluoromethyl Keton is a widely used caspase inhibitor that can inhibit Fas-mediated phagocytosis and oxidative burst inhibition, but does not affect the chemotactic activity of IL-8.

  • GC70289 structure
    GC70289AC-VEID-CHO TFA
    Purity: >98.00%

    AC-VEID-CHO (TFA) is a peptide-derived caspase inhibitor and has potency of inhibition for Caspase-6, Caspase-3 and Caspase-7 with IC50 values of 16.2 nM, 13.6 nM and 162.1 nM, respectively.

  • GC71214 structure
    GC71214CZL55
    CAS: 667408-87-9
    Purity: >98.00%

    CZL55 is a caspase-1 inhibitor with an IC50 value of 24 nM.

  • GC72147 structure
    GC72147Mca-YVADAP-Lys(Dnp)-OH TFA
    Purity: >98.00%

    Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).

  • GC72803 structure
    GC72803Aspidin BB
    CAS: 584-28-1
    Purity: >98.00%

    Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii.

  • GC72985 structure
    GC72985Z-LEVD-FMK
    CAS: 1135688-25-3
    Purity: >98.50%

    Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor.

  • GC72994 structure
    GC72994RAPTA-C
    CAS: 372948-28-2
    Purity: >99.00%

    RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent.

  • GC73272 structure
    GC73272PARP-1-IN-3
    CAS: 2976342-33-1
    Purity: >99.00%

    PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively.

  • GC73374 structure
    GC73374TD1092
    Purity: >99.00%

    TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP.

  • GC73417 structure
    GC73417CASP8-IN-1
    CAS: 1956368-39-0
    Purity: >98.00%

    CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 (CASP8), with an IC50 of 0.7 μM.

  • GC73585 structure
    GC73585(Rac)-M826
    CAS: 2649883-37-2

    (Rac)-M826 is the racemate of M826.

  • GC73619 structure
    GC73619M190S
    CAS: 2578300-07-7
    Purity: >99.00%

    M190S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo.

  • GC73642 structure
    GC73642ALK-IN-26
    CAS: 2447607-85-2
    Purity: >99.00%

    ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase.

  • GC73760 structure
    GC73760Trilexium
    CAS: 1983180-82-0
    Purity: >99.00%

    Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1.

  • GC74252 structure
    GC74252Euphornin
    CAS: 80454-47-3
    Purity: >98.00%

    Euphornin is a anticaner agent, that can be isolated from E. helioscopia.

  • GC74380 structure
    GC74380Ac-VRPR-AMC TFA
    Purity: >99.00%

    Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate.

  • GC74668 structure
    GC746683-Methoxy-9H-Carbazole
    CAS: 18992-85-3
    Purity: >99.00%

    3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species.

  • GC78798 structure
    GC78798NN3201
    Purity: >99.00%

    NN3201 is a c-Kit -targeting antibody-drug conjugate ( ADC ) with high affinity ( K D = 0.19 pM).

  • GC78810 structure
    GC78810Anisomelic acid
    CAS: 59632-76-7
    Purity: >98%

    Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor.

  • GC78941 structure
    GC78941KLA peptide acetate
    Purity: >99.50%

    KLA peptide acetate is a naturally occurring Antibiotic peptide that is nontoxic outside of cells but is toxic when it enters into the interior of targeted cells.

  • GC78949 structure
    GC78949Caspase-4-IN-1
    CAS: 3121390-12-0
    Purity: >98.00%

    Caspase-4-IN-1 (compound 35) is a selective allosteric caspase-4 inhibitor that spares caspase-1, and in embodiments acts as a dual caspase-4/5 inhibitor [1] .

  • GC78950 structure
    GC789504′-O-Methylglabridin
    CAS: 68978-09-6
    Purity: >98.50%

    4′-O-Methylglabridin is an apoptosis inducer with antioxidant, cell cycle-disrupting and anticancer cytotoxic activities.

  • GC78951 structure
    GC78951NOTA-GZP
    CAS: 2171121-32-5
    Purity: >99.50%

    NOTA-GZP is a high-affinity, specific granzyme B -targeted irreversible inhibitory peptide PET imaging probe.