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Home >> Signaling Pathways >> Proteases >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for  Caspase

  1. Cat.No. Product Name Information
  2. GC66048 δ-Secretase inhibitor 11 δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research. δ-Secretase inhibitor 11 Chemical Structure
  3. GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death 15-acetoxy Scirpenol Chemical Structure
  4. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. 2-HBA Chemical Structure
  5. GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 5,7,4'-Trimethoxyflavone Chemical Structure
  6. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  7. GC17602 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3 Ac-DEVD-AFC Chemical Structure
  8. GC32695 Ac-DEVD-CHO Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM. Ac-DEVD-CHO Chemical Structure
  9. GC10951 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase Ac-DEVD-CMK Chemical Structure
  10. GC60558 Ac-FLTD-CMK Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK Chemical Structure
  11. GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11 Ac-FLTD-CMK (trifluoroacetate salt) Chemical Structure
  12. GC10258 Ac-IEPD-AFC Ac-IEPD-AFC Chemical Structure
  13. GC10968 Ac-LEHD-AFC A caspase-4, -5, and -9 fluorogenic substrate Ac-LEHD-AFC Chemical Structure
  14. GC14209 Apoptosis Activator 2 An activator of caspases Apoptosis Activator 2 Chemical Structure
  15. GC10160 Apoptosis Inhibitor A cell-permeable inhibitor of caspase-3 activation Apoptosis Inhibitor Chemical Structure
  16. GC35388 Aristolactam I Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristolactam I Chemical Structure
  17. GC35395 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  18. GC60603 Asperosaponin VI A triterpenoid saponin with diverse biological activities Asperosaponin VI Chemical Structure
  19. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide AZ 10417808 Chemical Structure
  20. GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK . Biotin-VAD-FMK Chemical Structure
  21. GC16774 Boc-D-FMK An irreversible pan-caspase inhibitor Boc-D-FMK Chemical Structure
  22. GC11718 Caspase-3/7 Inhibitor I An isatin sulfonamide-based inhibitor of caspase-3 and caspase-7 Caspase-3/7 Inhibitor I Chemical Structure
  23. GC43154 CAY10443 Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. CAY10443 Chemical Structure
  24. GC31886 Chelidonic acid A pyran with diverse biological activities Chelidonic acid Chemical Structure
  25. GC11908 Cisplatin

    Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers.

     Cisplatin Chemical Structure
  26. GN10040 Dehydrocorydaline Dehydrocorydaline Chemical Structure
  27. GC38452 Dehydrotrametenolic acid Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid Chemical Structure
  28. GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis Destruxin B Chemical Structure
  29. GC35908 Duocarmycin A Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels. Duocarmycin A Chemical Structure
  30. GN10564 Ecdysterone Ecdysterone Chemical Structure
  31. GC35980 Emricasan A pan-caspase inhibitor Emricasan Chemical Structure
  32. GC31390 EP1013 (F1013) EP1013 (F1013) (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. EP1013 (F1013) Chemical Structure
  33. GC12139 Gambogic Acid A xanthonoid with anticancer activity Gambogic Acid Chemical Structure
  34. GN10686 Ginsenoside Rh2 Ginsenoside Rh2 Chemical Structure
  35. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 Chemical Structure
  36. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  37. GC50368 INF 4E Caspase-1 and NLRP3 inflammasome inhibitor INF 4E Chemical Structure
  38. GC18137 Ivachtin A reversible caspase-3 inhibitor Ivachtin Chemical Structure
  39. GC63031 KEA1-97 KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. KEA1-97 Chemical Structure
  40. GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine Chemical Structure
  41. GC33309 ML132 (NCGC 00185682) ML132 (NCGC 00185682) (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM. ML132 (NCGC 00185682) Chemical Structure
  42. GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. MPT0B392 Chemical Structure
  43. GC45515 MX1013   MX1013 Chemical Structure
  44. GC44409 Nivalenol Nivalenol is a type B trichothecene mycotoxin produced by Fusarium that is commonly found in contaminated foods. Nivalenol Chemical Structure
  45. GC12639 NS3694 inhibits apoptosome formation and caspase activation NS3694 Chemical Structure
  46. GC11993 PAC-1 An in vitro procaspase-3 activator PAC-1 Chemical Structure
  47. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  48. GC15880 Penicillic Acid mycotoxin Penicillic Acid Chemical Structure
  49. GC14886 PETCM PETCM Chemical Structure
  50. GC38064 PETCM PETCM Chemical Structure
  51. GC36895 Phenoxodiol A phenol with anticancer activity Phenoxodiol Chemical Structure
  52. GC62567 Pralnacasan Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan Chemical Structure
  53. GC11713 Q-VD(OMe)-OPh Pan-caspase inhibitor Q-VD(OMe)-OPh Chemical Structure
  54. GC16316 Q-VD-OPh hydrate A caspase inhibitor with low cytotoxicity Q-VD-OPh hydrate Chemical Structure
  55. GC65474 QM31 QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. QM31 Chemical Structure
  56. GC63914 Raptinal Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9. Raptinal Chemical Structure
  57. GC62444 SDZ 224-015 SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 Chemical Structure
  58. GC15267 Se-Aspirin nonsteroidal anti-inflammatory drug Se-Aspirin Chemical Structure
  59. GN10801 Senkyunolide I Senkyunolide I Chemical Structure
  60. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  61. GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Taurochenodeoxycholic acid (12-Deoxycholyltaurine) (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Chemical Structure
  62. GC37745 Taurodeoxycholic acid sodium hydrate

    Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

     Taurodeoxycholic acid sodium hydrate Chemical Structure
  63. GC34181 Tauroursodeoxycholate (TUDCA) Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK. Tauroursodeoxycholate (TUDCA) Chemical Structure
  64. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate Chemical Structure
  65. GC10978 Terfenadine Histamine H1-receptor antagonist Terfenadine Chemical Structure
  66. GC37780 Thevetiaflavone Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. Thevetiaflavone Chemical Structure
  67. GC63256 VRT-043198 VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 Chemical Structure
  68. GC12725 VX-765

    A prodrug form of VRT-043198

     VX-765 Chemical Structure
  69. GN10269 Wedelolactone Wedelolactone Chemical Structure
  70. GC12223 Z-Asp-CH2-DCB caspase inhibitor Z-Asp-CH2-DCB Chemical Structure
  71. GC66403 Z-DEVD-AMC Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates. Z-DEVD-AMC Chemical Structure
  72. GC12287 Z-DEVD-FMK Inhibitor of caspase-3 Z-DEVD-FMK Chemical Structure
  73. GC16744 Z-DQMD-FMK Caspase-3 inhibitor,cell-permeable Z-DQMD-FMK Chemical Structure
  74. GC15066 Z-FA-FMK An inhibitor of cysteine proteases, including cathepsin B Z-FA-FMK Chemical Structure
  75. GC12407 Z-IETD-FMK Caspase-8 inhibitor Z-IETD-FMK Chemical Structure
  76. GC16990 Z-LEHD-FMK Irreversible Caspase-9 inhibitor. Z-LEHD-FMK Chemical Structure
  77. GC26092 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. Z-LEHD-FMK TFA Chemical Structure
  78. GC45189 Z-VAD(OH)-FMK Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. Z-VAD(OH)-FMK Chemical Structure
  79. GC12861 Z-VAD-FMK Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Z-VAD-FMK Chemical Structure
  80. GC11218 Z-VDVAD-FMK Z-VDVAD-FMK Chemical Structure
  81. GC13413 Z-VEID-FMK Z-VEID-FMK Chemical Structure
  82. GC12190 Z-WEHD-FMK Z-WEHD-FMK Chemical Structure
  83. GC14188 Z-YVAD-FMK Caspase-1 inhibitor Z-YVAD-FMK Chemical Structure
  84. GC37974 ZYZ-488 ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3. ZYZ-488 Chemical Structure

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