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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

  1. Cat.No. Product Name Information
  2. GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death
  3. GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
  4. GN10629 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
  5. GC32695 Ac-DEVD-CHO
  6. GC10258 Ac-IEPD-AFC Recognition motif for serine protease granzyme B
  7. GC10968 Ac-LEHD-AFC Fluorogenic caspase substrate
  8. GC14209 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable
  9. GC10160 Apoptosis Inhibitor

    Associate with caspase-3 inhibition

  10. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  11. GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK .
  12. GC16774 Boc-D-FMK Pan-caspase inhibitor
  13. GC11718 Caspase-3/7 Inhibitor I Caspase-3/7 inhibitor
  14. GC31886 Chelidonic acid
  15. GC11908 Cisplatin

    Inhibits DNA synthesis,chemotherapy drug

  16. GN10040 Dehydrocorydaline Extracted from Corydalis yanhusuo W.T. Wang dried rhizome;Store the product in sealed, cool and dry condition
  17. GC38452 Dehydrotrametenolic acid
  18. GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis
  19. GN10564 Ecdysterone Ecdysteroid hormone,naturally occurring
  20. GC35980 Emricasan
  21. GC31390 EP1013 (F1013)

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