Caspase

NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC 50 of 33.1 nM.

ZX079 is a dual BRD4 and CBP PROTAC degrader with a BRD4 DC 50 value of 0.035 nM and a CBP DC 50 value of < 0.02 nM.

PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC 50 of 20 nM against PDGFRA, a K i of 93.3 nM against CA IX, and a K i of 80.0 nM against CA XII.

MST3-IN-1 TFA (Compound LD-1) is a selective and orally active MST3 inhibitor, with an IC 50 of 122.4 nM.

CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC 50 of 1250 nM.

dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM.

Maxadilan TFA is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies.

M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor.

Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues.

BCS12 is a CAIX inhibitor.

MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM.

DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively.

4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found.

Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor.

NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).

Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.

Ecdysterone is a naturally occurring ecdysone that controls molting (feathering) and metamorphosis in arthropods.

5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.

Senkyunolide I is a natural phthalide existing in L. chuanxiong and A. sinensis with good blood-brain barrier permeability, which has the potential to become a cardio-cerebral vascular drug candidate.

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell-permeable inhibitor of caspase-8.

Z-LEHD-FMK is an irreversible caspase-9 inhibitor.

Cisplatin, a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors.