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Caspase

Caspase - Proteases - Signaling Pathways | GlpBio

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Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products Related to Caspase(168)

  • GC78952 structure
    GC78952d-(KLAKLAK)2, Proapoptotic Peptide acetate
    Purity: >98.00%

    d-(KLAKLAK) 2, Proapoptotic Peptide acetate is a pro- Apoptotic peptide whose core mechanism of action is to disrupt organelle membranes, especially mitochondrial membranes, thereby inducing apoptosis.

  • GC78953 structure
    GC78953Haplophytin-A
    CAS: 366477-44-3
    Purity: >98.00%

    Haplophytin-A is a quinoline alkaloid.

  • GC78954 structure
    GC78954OH14
    CAS: 1018153-87-1
    Purity: >99.50%

    OH14 is a cellular FLICE-like inhibitory protein ( cFLIP) inhibitor and TNF-related apoptosis-inducing ligand ( TRAIL ) sensitizer.

  • GC78957 structure
    GC78957(2S,3R,4S)-ASX-173
    CAS: 2748800-07-7
    Purity: >99.00%

    (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

  • GC78958 structure
    GC78958TMLB-C16
    CAS: 2923531-50-2
    Purity: >99.00%

    TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

  • GC78961 structure
    GC78961GPS167
    CAS: 3034312-19-8
    Purity: >98%

    GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4.

  • GC78962 structure
    GC78962MS1129
    Purity: >98%

    MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins.

  • GC79004 structure
    GC79004PMV6-PEG4-BI2536
    Purity: >98.00%

    PMV6-PEG4-BI2536 is an RIPTAC-like bifunctional molecule that promotes the formation of the p53 Y 220C -PLK1 ternary complex ( EC 50 = 1.4 μM).

  • GC79072 structure
    GC79072MS6076
    Purity: >98%

    MS6076 is a mitochondrial protease ClpP agonist.

  • GC79103 structure
    GC79103Berzosertib hydrochloride
    CAS: 1428935-04-9
    Purity: >98.50%

    Berzosertib (VE-822) hydrochloride is an orally active, CNS-penetrant, and selective ATR kinase inhibitor.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC79144 structure
    GC79144MC3817 free base
    Purity: >98%

    MC3817 free base is a selective DNMT1 inhibitor.

  • GC79145 structure
    GC79145MC3817
    Purity: >99.50%

    MC3817 is a selective DNMT1 inhibitor.

  • GC79147 structure
    GC79147HLC40
    Purity: >99.50%

    HLC40 is a MLL1 histone methyltransferase inhibitor with an IC 50 of 0.82 μM by binding to WDR5.

  • GC79337 structure
    GC79337ZSTK3744
    Purity: >98.00%

    ZSTK3744 is an aryl hydrocarbon receptor ( AhR ) agonist.

  • GC79451 structure
    GC79451JP-11646
    CAS: 1902983-63-4
    Purity: >98.50%

    JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM).

  • GC79475 structure
    GC79475MKK7-JNK activator 1
    CAS: 3100092-62-1
    Purity: >99.50%

    MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator.

  • GC79577 structure
    GC79577PFKFB4-IN-1
    CAS: 2664831-55-2
    Purity: >99.50%

    PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.

  • GC79806 structure
    GC79806TKL002
    CAS: 3098518-95-4
    Purity: >98.00%

    TKL002 is a blood-brain barrier-permeable inhibitor of the CTH/H 2 S/NF-κB/EMT signaling axis.

  • GC79807 structure
    GC79807RP-182 acetate
    Purity: >98.50%

    RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 ( K d = 8 μM) on the surface of tumor-associated macrophages (TAMs).

  • GC79871 structure
    GC79871CHNQD-00824
    CAS: 2222643-74-3
    Purity: >98%

    CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.

  • GC80880 structure
    GC80880dCASP1-55
    Purity: >98%

    dCASP1-55 is a cereblon-dependent caspase-1 ( CASP1 ) PROTAC degrader.

  • GC80886 structure
    GC80886PROTAC CDK2/4/6 Degrader-2
    CAS: 2541626-49-5
    Purity: >97.00%

    PROTAC CDK2/4/6 Degrader-2 is a CDK2/4/6 PROTAC degrader.

  • GC80887 structure
    GC80887MA203
    Purity: >98%

    MA203 is a selective CHK1 PROTAC degrader.