Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
Products for Caspase
- Cat.No. Product Name Information
- GC66048 δ-Secretase inhibitor 11 δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research.
- GC11988 15-acetoxy Scirpenol mycotoxin that induce apoptotic cell death
- GC12545 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
- GC35150 5,7,4'-Trimethoxyflavone 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner.
- GN10629 5,7-dihydroxychromone
- GC17602 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3
- GC32695 Ac-DEVD-CHO Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
- GC10951 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase
- GC60558 Ac-FLTD-CMK Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor.
- GC49704 Ac-FLTD-CMK (trifluoroacetate salt) An inhibitor of caspase-1, -4, -5, and -11
- GC10258 Ac-IEPD-AFC
- GC10968 Ac-LEHD-AFC A caspase-4, -5, and -9 fluorogenic substrate
- GC14209 Apoptosis Activator 2 An activator of caspases
- GC10160 Apoptosis Inhibitor A cell-permeable inhibitor of caspase-3 activation
- GC35388 Aristolactam I Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.
- GC35395 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner.
- GC60603 Asperosaponin VI A triterpenoid saponin with diverse biological activities
- GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
- GC18476 Biotin-VAD-FMK Biotin-VAD-FMK is a biotin-conjugated form of the pan-caspase inhibitor Z-VAD(OH)-FMK .
- GC16774 Boc-D-FMK An irreversible pan-caspase inhibitor
- GC11718 Caspase-3/7 Inhibitor I An isatin sulfonamide-based inhibitor of caspase-3 and caspase-7
- GC43154 CAY10443 Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.
- GC31886 Chelidonic acid A pyran with diverse biological activities
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GC11908
Cisplatin
Cisplatin is one of the best and first metal-based chemotherapeutic drugs, which is used for wide range of solid cancers such as testicular, ovarian, bladder, lung, cervical, head and neck cancer, gastric cancer and some other cancers.
- GN10040 Dehydrocorydaline
- GC38452 Dehydrotrametenolic acid Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos.
- GC10661 Destruxin B insecticidal and phytotoxic activity;induces apoptosis
- GC35908 Duocarmycin A Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.
- GN10564 Ecdysterone
- GC35980 Emricasan A pan-caspase inhibitor
- GC31390 EP1013 (F1013) EP1013 (F1013) (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
- GC12139 Gambogic Acid A xanthonoid with anticancer activity
- GN10686 Ginsenoside Rh2
- GC32998 Ginsenoside Rh4
- GC17658 Guggulsterone Broad spectrum steroid receptor ligand
- GC50368 INF 4E Caspase-1 and NLRP3 inflammasome inhibitor
- GC18137 Ivachtin A reversible caspase-3 inhibitor
- GC63031 KEA1-97 KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity.
- GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation.
- GC33309 ML132 (NCGC 00185682) ML132 (NCGC 00185682) (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 of 34.9 nM.
- GC36652 MPT0B392 MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.
- GC45515 MX1013
- GC44409 Nivalenol Nivalenol is a type B trichothecene mycotoxin produced by Fusarium that is commonly found in contaminated foods.
- GC12639 NS3694 inhibits apoptosome formation and caspase activation
- GC11993 PAC-1 An in vitro procaspase-3 activator
- GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
- GC15880 Penicillic Acid mycotoxin
- GC14886 PETCM
- GC38064 PETCM
- GC36895 Phenoxodiol A phenol with anticancer activity
- GC62567 Pralnacasan Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM.
- GC11713 Q-VD(OMe)-OPh Pan-caspase inhibitor
- GC16316 Q-VD-OPh hydrate A caspase inhibitor with low cytotoxicity
- GC65474 QM31 QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.
- GC63914 Raptinal Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9.
- GC62444 SDZ 224-015 SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1.
- GC15267 Se-Aspirin nonsteroidal anti-inflammatory drug
- GN10801 Senkyunolide I
- GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
- GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine) Taurochenodeoxycholic acid (12-Deoxycholyltaurine) (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
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GC37745
Taurodeoxycholic acid sodium hydrate
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
- GC34181 Tauroursodeoxycholate (TUDCA) Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK.
- GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
- GC10978 Terfenadine Histamine H1-receptor antagonist
- GC37780 Thevetiaflavone Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3.
- GC63256 VRT-043198 VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.
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GC12725
VX-765
A prodrug form of VRT-043198
- GN10269 Wedelolactone
- GC12223 Z-Asp-CH2-DCB caspase inhibitor
- GC66403 Z-DEVD-AMC Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates.
- GC12287 Z-DEVD-FMK Inhibitor of caspase-3
- GC16744 Z-DQMD-FMK Caspase-3 inhibitor,cell-permeable
- GC15066 Z-FA-FMK An inhibitor of cysteine proteases, including cathepsin B
- GC12407 Z-IETD-FMK Caspase-8 inhibitor
- GC16990 Z-LEHD-FMK Irreversible Caspase-9 inhibitor.
- GC26092 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
- GC45189 Z-VAD(OH)-FMK Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
- GC12861 Z-VAD-FMK Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.
- GC11218 Z-VDVAD-FMK
- GC13413 Z-VEID-FMK
- GC12190 Z-WEHD-FMK
- GC14188 Z-YVAD-FMK Caspase-1 inhibitor
- GC37974 ZYZ-488 ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3.