15-Lipoxygenase Inhibitor 1 (Synonyms: 15LO Inhibitor 1) |
| Catalog No.GC41938 |
15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 15-Lipoxygenase Inhibitor 1 has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 15-Lipoxygenase Inhibitor 1 has potential for the research of prostate cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 928853-86-5
Sample solution is provided at 25 µL, 10mM.
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Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM. The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.
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