Stem Cell

GSK3 Substrate, α, β subunit is a peptide substrate of glycogen synthase kinase-3 (GSK-3) that can be used to measure GSK-3 activity.

IHMT-MST1-58 is an effective and selective inhibitor of STE20-like protein 1 kinase (MST1), with oral activity and an IC50 value of 23 nM. IHMT-MST1-58 can be used for research on type 1 or type 2 diabetes.

Miclxin (DS37262926) is an effective inhibitor of mutant β-catenin, involved in the Wnt signaling pathway. Miclxin can induce β-catenin-dependent apoptosis, leading to mitochondrial damage and loss of mitochondrial membrane. Miclxin targets MIC60 to kill tumors, which is a major component of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Orobol is a major soy isoflavone with various pharmacological activities, including anti-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K subtypes (for PI3K α/β/γ/K/δ, IC50=3.46-5.27 μM).

RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75 and 93 ng/mL respectively. RA-V can be used for research on cancer-related signaling pathways.

(R)-VT104 is the R-enantiomer of VT104. The IC50 value of (R)-VT104 for firefly luciferase is 0.1-1 μμ. VT104 is an orally active pan-TEAD deacetylase inhibitor.

TEAD-IN-3 (compound I-177) is an effective inhibitor of the TEAD transcription factor. TEAD-IN-3 can be used for research on proliferative diseases such as cancer.

VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1 and 0.52 nM for LATS2). It targets the Hippo signaling pathway and inhibits the growth of ER+ breast cancer cell lines and tumor organoids derived from patients, as well as ESR1 expression.

VT104 is an orally effective inhibitor of YAP/TAZ. It prevents the palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in cancer research.

WIC1 is an effective Wnt inhibitor that can be used in cancer research.

Wnt pathway activator 2 is an effective Wnt activator with an EC50 value of 13 nM. For more information, please refer to patent WO2012024404A1, compound 2.

Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signaling pathway activator. Wnt/β-catenin agonist 3 (compound 98) can be used for research on osteoporosis.

TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity.

6-Me-ATP (N6-Methyl-ATP) trisodium is a N6-modified ATP derivative.

Casein kinase 1δ-IN-6 is a potent and selective protein kinase CK-1δ inhibitor with an IC50 of 23 nM.

NIBR-LTSi is a highly selective, active-site binding LATS kinase inhibitor displayed an IC 50 of 2.16µM.

Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide.

Tarlatamab is a half-life extended bispecific T-cell engager molecule targeting delta-like ligand 3 (DLL3).

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4.

β-catenin-IN-6 is a β-catenin inhibitor, targeting to canonical Wingless-related integration site signaling pathway.

NSC260594 induces Apoptosis.

1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine.

SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively.

HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM.