Stem Cell

Box5 is a potent Wnt5a antagonist.

JI130 (JI051 derivative ) is a stabilizer for the Hes1-PHB2 interaction.

PF-07104091 drate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively.

GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD.

CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM.

YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM.

SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.

CDK8-IN-11 is a potent and selective CDK8 inhibitor with an IC50 value of 46 nM.

YAP-TEAD-IN-2 (compound 6) is a potent YAP-TEAD PPI (protein-protein interaction) inhibitor with IC50 is 2.7 nM.

YW2036 (compound 2a) is a potent Wnt/β-Catenin signaling pathway inhibitor with an IC50 value of 637 nM.

IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM.

CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with an IC50 values of 123, 19.8, 26.8, 74.3 nM for CK1a, CK1d, CK1e, p38a, respectively.

LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms.

MY-1076 is an inhibitor of YAP.

hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity.

F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM).

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively.

DEG-77, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h).

DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling.

JA310 is a highly selective MST3 kinase inhibitor.

SJ3149 is a selective and potent in vitro and in vivo degrader of CK1α protein with broad antiproliferative activity.

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively.

PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin.