GLPBio

FGFR

FGFRs (fibroblast growth factor receptors) are transmembrane tyrosine kinase receptor. It is involved in carcinogenesis and plays an important role in cell differentiation, survival and proliferation etc.

Products Related to FGFR(109)

  • GC16327 structure
    GC16327Pazopanib (GW-786034)
    CAS: 444731-52-6
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC16519 structure
    GC16519ENMD-2076
    CAS: 934353-76-1
    Purity: >98.00%

    A multi-kinase inhibitor

  • GC16732 structure
    GC16732TSU-68 (SU6668,Orantinib)
    CAS: 252916-29-3
    Purity: >98.50%

    TSU-68 (SU6668,Orantinib) (SU6668; TSU-68) is a multi-targeted receptor tyrosine kinase inhibitor with Kis of 2.1 μM, 8 nM and 1.2 μM for Flt-1, PDGFRβ and FGFR1, respectively.

  • GC17323 structure
    GC17323FIIN-2
    CAS: 1633044-56-0
    Purity: >99.50%

    Irreversible inhibitor of FGFR

  • GC17943 structure
    GC17943PD173074
    CAS: 219580-11-7
    Purity: >98.00%

    PD173074 is an ATP-competitive FGFR1 and VEGFR2 inhibitor with an IC 50 value of 26nM and 100-200nM, respectively, showing higher selectivity for FGFR1 over PDGFR and c-Src.

  • GC19075 structure
    GC19075BLU-554
    CAS: 1707289-21-1
    Purity: >99.50%

    BLU-554 is a selective inhibitor of fibroblast growth factor receptor 4 (FGFR4) (IC 50 = 5nM).

  • GC19142 structure
    GC19142Erdafitinib
    CAS: 1346242-81-6
    Purity: >99.50%

    Erdafitinib is an orally available, selective tyrosine kinase inhibitor of the entire FGFR family (FGFR1: IC 50 = 1.2nM; FGFR2: IC 50 = 2.5nM; FGFR3: IC 50 = 3.0nM; FGFR4: IC 50 = 5.7nM).

  • GC19154 structure
    GC19154Roblitinib
    CAS: 1708971-55-4
    Purity: >99.00%

    Roblitinib is an orally active fibroblast growth factor receptor 4 (FGFR4) antagonist (IC 50 =1.9nM).

  • GC19155 structure
    GC19155FGFR4-IN-1
    CAS: 1708971-72-5
    Purity: >99.50%

    FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

  • GC19156 structure
    GC19156TAS-120
    CAS: 1448169-71-8
    Purity: >98.00%

    TAS-120 is a highly bioavailable, selective, and irreversible fibroblast growth factor receptor (FGFR) inhibitor that demonstrates potent inhibitory activity against FGFR1-4, with IC₅₀ values of 3.9nM, 1.3nM, 1.6nM, and 8.3nM.

  • GC19187 structure
    GC19187H3B-6527
    CAS: 1702259-66-2
    Purity: >98%

    H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.

  • GC19279 structure
    GC19279PD-166866
    CAS: 192705-79-6
    Purity: >99.50%

    PD-166866 is a selective and orally active FGFR1 (fibroblast growth factor receptor 1) tyrosine kinase inhibitor, with an IC₅₀ of 52.4nM.

  • GC19317 structure
    GC19317S49076
    CAS: 1265965-22-7
    Purity: >99.50%

    S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM.

  • GC19341 structure
    GC19341SUN11602
    CAS: 704869-38-5
    Purity: >98.00%

    SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity.

  • GC19399 structure
    GC19399Derazantinib
    CAS: 1234356-69-4
    Purity: >99.50%

    Derazantinib is a novel, ATP competitive, small molecule, multi-kinase inhibitor with IC 50 of 1.8nM for FGFR2, and 4.5nM for FGFR1 and 3.

  • GC30767 structure
    GC30767Heparan Sulfate
    CAS: 9050-30-0

    Heparan Sulfate is a complex polyanionic polysaccharide, regulates important developmental processes in invertebrates and vertebrates.

  • GC31495 structure
    GC31495PF-05231023
    CAS: 1037589-69-7
    Purity: >98.00%

    PF-05231023 is a long-acting fibroblast growth factor 21 (FGF21) analog.

  • GC32127 structure
    GC32127Alofanib (RPT835)
    CAS: 1612888-66-0
    Purity: >98.50%

    Alofanib (RPT835) (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2).

  • GC32760 structure
    GC32760Dovitinib lactate (CHIR-258 lactate)
    CAS: 692737-80-7
    Purity: >99.50%

    Dovitinib lactate (CHIR-258 lactate) (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively.

  • GC32802 structure
    GC32802PRN1371
    CAS: 1802929-43-6
    Purity: >99.50%

    An irreversible pan-FGFR inhibitor

  • GC32805 structure
    GC32805Sulfatinib (HMPL-012)
    CAS: 1308672-74-3
    Purity: >98.00%

    Sulfatinib (HMPL-012) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM.

  • GC32835 structure
    GC32835PP58
    CAS: 212391-58-7
    Purity: >99.00%

    PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.

  • GC32915 structure
    GC32915Pemigatinib
    CAS: 1513857-77-6
    Purity: >98.00%

    An FGFR inhibitor

  • GC33352 structure
    GC33352CP-547632
    CAS: 252003-65-9
    Purity: >98.50%

    A potent inhibitor of VEGFR2 and bFGF