ROCK2-IN-2
Catalog No.: GC31883Purity:>98%
ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1995065-79-6
10mM (in 1mL DMSO)In Stock
$82.00
1
1mgIn Stock
$43.00
1
5mgIn Stock
$103.00
1
10mgIn Stock
$172.00
1
25mgIn Stock
$295.00
1
50mgIn Stock
$400.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $82.00 | In Stock | 1 | |
| 1mg | $43.00 | In Stock | 1 | |
| 5mg | $103.00 | In Stock | 1 | |
| 10mg | $172.00 | In Stock | 1 | |
| 25mg | $295.00 | In Stock | 1 | |
| 50mg | $400.00 | In Stock | 1 |
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Citations
2 publicationsPublications from researchers using this productDescription
ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
Rho-associated protein kinase (ROCK) is a member of the serine-threonine protein kinase family. ROCK, which exists in two isoforms, ROCK1 and ROCK2, is an effector molecule of RhoA, and the RhoA/ROCK signaling pathway is involved in a number of cellular functions, which include, for example, actin organization, cell adhesion, cell migration, and cytokinesis. In addition, the RhoA/ROCK signaling pathway is involved in regulating smooth muscle contraction. Inhibitors of ROCK have been reported to be useful for treating multiple medical disorders, such as fibrosis, inflammatory disorders, autoimmune disorders, and cardiovascular disorders[1].
[1]. Aicher, Thomas Daniel, et al. INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE. US20180093978A1.
Chemical Properties
CAS No.
1995065-79-6
SMILES
C12=CC(NC3=NN=C(C4=CC(C5=NC=CO5)=CC=C4)S3)=CC=C1NN=C2
Molecular Formula
C18H12N6OS
Molecular Weight
360.39
Solubility
DMSO : 100 mg/mL (277.48 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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