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Home >> Signaling Pathways >> TGF-β / Smad Signaling >> ROCK

ROCK

ROCK (Rho-associated protein kinase) is a kinase belonging to the AGC family of serine-threonine kinases and takes part in regulating the shape and movement of cells by acting on the cytoskeleton.

Products for  ROCK

  1. Cat.No. Product Name Information
  2. GC16475 Afuresertib

    GSK2110183

     pan-AKT inhibitor Afuresertib Chemical Structure
  3. GC42747 Afuresertib (hydrochloride)

    GSK2110183B

     Afuresertib is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. Afuresertib (hydrochloride) Chemical Structure
  4. GC34300 AR-13324 analog mesylate AR-13324 analog mesylate Chemical Structure
  5. GC19034 AR-13324 mesylate AR-13324 is a potent inhibitor of ROCK I and ROCK II that has been shown to induce morphologic changes in cultured human and porcine TM cells at low concentration. AR-13324 mesylate Chemical Structure
  6. GC17712 AT13148 Multi-AGC kinase inhibitor,ATP-competitive AT13148 Chemical Structure
  7. GC35442 Azaindole 1

    ROCK-IN-2 ，TC-S 7001

     Azaindole 1 (Azaindole 1; TC-S 7001) is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1nM for human ROCK-1 and ROCK-2, respectively. Azaindole 1 Chemical Structure
  8. GC32868 BDP5290 BDP5290 is a potent inhibitor of ROCK and MRCK with IC50 values of 17nM, 230nM, 123nM and 100nM for MRCKβ, ROCK1, ROCK2, respectively. BDP5290 Chemical Structure
  9. GC43184 CAY10622 Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. CAY10622 Chemical Structure
  10. GC38898 CCG-222740 CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis. CCG-222740 Chemical Structure
  11. GC71281 Chroman 1 dihydrochloride Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride Chemical Structure
  12. GC43286 CMPD101 A GRK2 and GRK3 inhibitor CMPD101 Chemical Structure
  13. GC72959 DJ4 DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM). DJ4 Chemical Structure
  14. GC13869 Fasudil Fasudil (HA-1077; AT877) is a non-specific RhoA/ROCK inhibitor with a Ki of 0.33μM and an IC50 of 0.158μM for ROCK1, and IC50 of 4.58μM, 12.30μM, and 1.650μM for ROCK2, PKA, PKC, and PKG, respectively. Fasudil Chemical Structure
  15. GC14289 Fasudil (HA-1077) HCl Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator. Fasudil (HA-1077) HCl Chemical Structure
  16. GC38791 GSK-25 GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 Chemical Structure
  17. GC19177 GSK180736A GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 uM. GSK180736A Chemical Structure
  18. GC17936 GSK269962A

    GSK269962A, GSK269962B

     ROCK inhibitor GSK269962A Chemical Structure
  19. GC25482 GSK269962A HCl

    GSK269962B, GSK269962, GSK 269962

     GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. GSK269962A HCl Chemical Structure
  20. GC18119 GSK429286A Selective ROCK1/ROCK2 inhibitor GSK429286A Chemical Structure
  21. GC36207 H-1152 H-1152 is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. H-1152 Chemical Structure
  22. GC36208 H-1152 dihydrochloride H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. H-1152 dihydrochloride Chemical Structure
  23. GC12817 K-115 hydrochloride dihydrate K-115 hydrochloride dihydrate (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. K-115 hydrochloride dihydrate Chemical Structure
  24. GC70857 LIMK-IN-1 LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 Chemical Structure
  25. GC44094 LX7101 (hydrochloride) LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. LX7101 (hydrochloride) Chemical Structure
  26. GC12402 LX7101 HCL LX7101 HCL is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively; also inhibits PKA with an IC50 less than 1 nM. LX7101 HCL Chemical Structure
  27. GC10716 Netarsudil (AR-13324) ROCK inhibitor Netarsudil (AR-13324) Chemical Structure
  28. GC33901 Pentanoic acid Pentanoic acid Chemical Structure
  29. GC69776 PT-262

    PT-262 is an effective ROCK inhibitor with an IC50 value of approximately 5 μM. PT-262 induces loss of mitochondrial membrane potential and increases activation of caspase-3 and cell apoptosis. PT-262 inhibits phosphorylation of ERK and CDC2 through a p53-independent pathway. PT-262 blocks cellular cytoskeleton function and cell migration. PT-262 has anti-cancer activity.

     PT-262 Chemical Structure
  30. GC33310 Rho-Kinase-IN-1 Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. Rho-Kinase-IN-1 Chemical Structure
  31. GC66050 Rho-Kinase-IN-2 Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). Rho-Kinase-IN-2 can be used in Huntington's research. Rho-Kinase-IN-2 Chemical Structure
  32. GC70451 Rho-Kinase-IN-3 Rho-Kinase-IN-3 (compound 12) is a potent and selective Rho kinase (ROCK1) inhibitor with an IC50 value of 8 nM. Rho-Kinase-IN-3 Chemical Structure
  33. GC72976 Rhodblock 6 Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization. Rhodblock 6 Chemical Structure
  34. GC37534 Ripasudil free base

    K-115 (free base)

     Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. Ripasudil free base Chemical Structure
  35. GC37551 ROCK inhibitor-2 ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. ROCK inhibitor-2 Chemical Structure
  36. GC31952 ROCK-IN-1 ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2. ROCK-IN-1 Chemical Structure
  37. GC66338 ROCK1-IN-1 ROCK1-IN-1 is a ROCK1 inhibitor with a Ki value of 540 nM. ROCK1-IN-1 can be used for the research of hypertension, glaucoma and erectile dysfunction. ROCK1-IN-1 Chemical Structure
  38. GC31883 ROCK2-IN-2 ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. ROCK2-IN-2 Chemical Structure
  39. GC71389 ROCK2-IN-6 hydrochloride ROCK2-IN-6 hydrochloride (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research. ROCK2-IN-6 hydrochloride Chemical Structure
  40. GC13759 SAR407899 ATP-competitive ROCK inhibitor SAR407899 Chemical Structure
  41. GC16289 SAR407899 hydrochloride ATP-competitive ROCK inhibitor SAR407899 hydrochloride Chemical Structure
  42. GC15170 SB 772077B dihydrochloride Rho-kinase (ROCK) inhibitor SB 772077B dihydrochloride Chemical Structure
  43. GC10722 SR-3677 Rho Kinase (ROCK-II) inhibitor SR-3677 Chemical Structure
  44. GC11181 Thiazovivin

    Tzv

     ROCK inhibitor Thiazovivin Chemical Structure
  45. GC73226 THK01 THK01 is a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. THK01 Chemical Structure
  46. GC15712 Y-27632

    A ROCK inhibitor,potent and selective

     Y-27632 Chemical Structure
  47. GC37947 Y-33075

    RKI-983, SNJ-1656, Y-39983

     Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. Y-33075 Chemical Structure
  48. GC13423 Y-39983 dihydrochloride ROCK family inhibitor Y-39983 dihydrochloride Chemical Structure
  49. GC71056 Zelasudil Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil Chemical Structure
  50. GC33120 ZINC00881524 A ROCK inhibitor ZINC00881524 Chemical Structure

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