SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1( SHP1 ) with an EC 50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent [1].
References:
[1]. Mu XY, et al., Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators. Eur J Med Chem. 2025 Apr 15;288:117394.
References:
[1]. Mu XY, et al., Development of coumarin and procaine linked hybrid molecules as a novel class of SHP1 fluorescent activators. Eur J Med Chem. 2025 Apr 15;288:117394.