MAPK Signaling

HPK1-IN-2 TFA is an orally active HPK1 inhibitor ( IC 50 < 0.05 µM) with antitumor activity.

IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC 50 value of 0.1 nM.

MD-3-A45 is an inhibitor of fibroblast growth factor 23 ( FGF-23 ).

APS03118 is an orally active, potent and selective rearranged during transfection ( RET ) inhibitor.

Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation.

ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 ( KCC2 ) with an IC 50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak ( IC 50 > 50 μM).

ST1072 is an inhibitor of CerS4 and CerS6.

Alcudacigib (ASP1570; DGKζ-IN-1) TFA is an orally active diacylglycerol kinase ζ ( DGKζ ) inhibitor, with an IC 50 of 4.7 nM against human DGKζ and an IC 50 of 3.0 nM against mouse DGKζ. Alcudacigib TFA selectively inhibits the kinase activity of DGKζ and induces proteasome-dependent degradation of DGKζ protein.

(E/Z)-Sinigrin ((E/Z)-Allyl-glucosinolate; (E/Z)-2-Propenyl-glucosinolate) free base is an orally active aliphatic thioglucoside anti-leukemia compound.

Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.

Hexestrol -d 4 is the deuterium labeled Hexestrol.

Semaglutide -d 8 tetraTFA is the deuterium labeled Semaglutide.

Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways.

Calebin A is a PI3K/Akt/mTOR, MAPK, and NF-κB inhibitor with oral effectiveness.

XL-418 is an orally active dual Akt and p70S6K inhibitor with IC 50 s of 1 nM for Akt1 and 2 nM for p70S6K.

JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor.

P38α ligand-1 is a p38α ligand that can be used for the synthesis of PROTACs, such as NR-7h [1] .

PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.

Tyrosine kinase-IN-11 (Compound 4b) is a tyrosine kinase inhibitor.

2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose is an FGFR3 and BRAF binder, and is an isovaleryl sucrose ester that can be found in Atractylodes japonica.

PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC 50 of 20 nM against PDGFRA, a K i of 93.3 nM against CA IX, and a K i of 80.0 nM against CA XII.

FGF7p is a small molecule peptide and a potential bladder protector.

VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold.

GZD-552 is a potent orally active FAK inhibitor with a human FAK IC 50 of 5.8 nM.