PARP
PARP Inhibitors
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Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.
Products Related to PARP(147)
- GC79061PARP1-IN-56CAS: 1574367-80-8Purity: >99.00%
PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor.
- GC79577PFKFB4-IN-1CAS: 2664831-55-2Purity: >99.50%
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels.
- GC79871CHNQD-00824CAS: 2222643-74-3Purity: >98%
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect.
- GC80334Rucaparib-d 3CAS: 2271225-13-7Purity: >98.00%
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib.
- GC80875PROTAC survivin degrader-1CAS: 3079079-69-6Purity: >98%
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC.
- GC80920PROTAC PARP2 degrader-1CAS: 2925182-32-5Purity: >95.50%
PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM.
- GC80924iVeliparib-AP6CAS: 2472645-27-3Purity: >98%
iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2.
- GC81312PARP1/c-Met-IN-3CAS: 3123529-62-1Purity: >98%
PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1.
- GN10040DehydrocorydalineCAS: 30045-16-0Purity: >98.00%
Dehydrocorydaline은 코리달리스 리좀의 4가 암모늄 알칼로이드 중 하나이다.
- GN106295,7-dihydroxychromoneCAS: 31721-94-5Purity: >99.00%
5,7-dihydroxychromone은 땅콩 껍질에서 유래한 플라보노이드 분해 생성물로 벨벳잎, 옥수수, 땅콩 및 밀의 배아근 신장을 억제한다.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79060 | A-620223 | 272769-49-0 | >96.00% | |
A-620223 is a PARP-1 inhibitor with a K i of 8 nM against PARP-1 and EC 50 of 3 nM in a whole cell assay. | ||||
| GC79061 | PARP1-IN-56 | 1574367-80-8 | >99.00% | |
PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor. | ||||
| GC79062 | PCIP-1 | - | >98.50% | |
PCIP-1 is a PARP2 inhibitor. | ||||
| GC79063 | TNKS-IN-1 | 59455-93-5 | >99.50% | |
TNKS-IN-1 is a selective and potent tankyrase ( TNKS1 / TNKS2 ) inhibitor with IC 50 values of 7.9 nM and 8.7 nM. | ||||
| GC79072 | MS6076 | - | >98% | |
MS6076 is a mitochondrial protease ClpP agonist. | ||||
| GC79451 | JP-11646 | 1902983-63-4 | >98.50% | |
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM). | ||||
| GC79577 | PFKFB4-IN-1 | 2664831-55-2 | >99.50% | |
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor ( IC 50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. | ||||
| GC79871 | CHNQD-00824 | 2222643-74-3 | >98% | |
CHNQD-00824 is a Terphenyllin derivative with potent anticancer effect. | ||||
| GC80334 | Rucaparib-d 3 | 2271225-13-7 | >98.00% | |
Rucaparib -d 3 (AG014699-d 3 ) is the deuterated -labeled Rucaparib. | ||||
| GC80875 | PROTAC survivin degrader-1 | 3079079-69-6 | >98% | |
PROTAC survivin degrader-1 is an orally active, CNS-penetrant survivin -targeting PROTAC. | ||||
| GC80920 | PROTAC PARP2 degrader-1 | 2925182-32-5 | >95.50% | |
PROTAC PARP2 degrader-1 is an orally active PARP2 PROTAC degrader with a DC 50 of 2 μM. | ||||
| GC80924 | iVeliparib-AP6 | 2472645-27-3 | >98% | |
iVeliparib-AP6 is a proteolysis-targeting chimera ( PROTAC ) molecule designed based on Veliparib, which targets PARP1/2. | ||||
| GC81312 | PARP1/c-Met-IN-3 | 3123529-62-1 | >98% | |
PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1. | ||||
| GC81499 | CT-179 | 1996636-69-1 | >99.50% | |
CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC 50 of 1250 nM. | ||||
| GC81512 | dCDK9-202 | - | >98.50% | |
dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM. | ||||
| GC81594 | TLSC702 | 748786-57-4 | >95.50% | |
TLSC702 is a human glyoxalase I ( hGLO I ) inhibitor with an IC 50 of 2.0 μM. | ||||
| GC81595 | BCS12 | 329719-71-3 | >99.50% | |
BCS12 is a CAIX inhibitor. | ||||
| GC81674 | MKI-3 | 3084702-28-0 | >98% | |
MKI-3 is a selective microtubule-associated serine/threonine kinase-like ( MASTL ) inhibitor with an IC 50 of 5.72 nM and a K d of 1.89 nM. | ||||
| GC81720 | DDO3602 | - | >98% | |
DDO3602 is a PARP1 HSPTAC ( HSP90 -mediated proteolysis-targeting chimera) degrader, with a DC 50 of 490.3 nM against PARP1; its K d values for PARP1 and HSP90 are 66.5 nM and 1.64 nM, respectively. | ||||
| GC81879 | NCP26 TFA | - | >99.50% | |
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline). | ||||
| GC91435 | YCH1899 | - | >98.00% | |
YCH1899는 poly(ADP-ribose) polymerase 1 (PARP1) 및 PARP2의 억제제입니다. (IC50s = 1). 이것은 PARP3, -4, -5A, -5B, -6, -7, -10 및 -12보다 PARP1과 PARP2에 선택적입니다. (IC50s = 1-14.1 nM). | ||||
| GN10040 | Dehydrocorydaline | 30045-16-0 | >98.00% | |
Dehydrocorydaline은 코리달리스 리좀의 4가 암모늄 알칼로이드 중 하나이다. | ||||
| GN10114 | Oroxin A | 57396-78-8 | >98.00% | |
| GN10629 | 5,7-dihydroxychromone | 31721-94-5 | >99.00% | |
5,7-dihydroxychromone은 땅콩 껍질에서 유래한 플라보노이드 분해 생성물로 벨벳잎, 옥수수, 땅콩 및 밀의 배아근 신장을 억제한다. | ||||