E3 ligase Ligand 1A (Synonyms: VHL ligand 2; E3 ligase Ligand 1A) |
| Catalog No.GC33101 |
E3 ligase Ligand 1A (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 ligase Ligand 1A can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
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Cas No.: 1948273-02-6
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 1A is a ligand of E3 ligase, used in PROTAC technology; E3 ligase Ligand 1A can be used in the research of cancer.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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