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Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Products Related to Monoamine Oxidase(100)

  • GC11703 structure
    GC11703Moclobemide (Ro 111163)
    CAS: 71320-77-9
    Purity: >99.50%

    Moclobemide (Ro 111163) is a reversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier, with an IC 50 value of 6.061μM for hMAO-A.

  • GC12801 structure
    GC12801Rasagiline Mesylate
    CAS: 161735-79-1
    Purity: >99.50%

    An inhibitor of MAO-B

  • GC12962 structure
    GC12962Isatin
    CAS: 91-56-5
    Purity: >98.00%

    endogenous monoamine oxidase inhibitor

  • GC13016 structure
    GC13016Safinamide
    CAS: 133865-89-1
    Purity: >99.50%
  • GC14122 structure
    GC14122Clorgyline (hydrochloride)
    CAS: 17780-75-5
    Purity: >99.50%

    Clorgyline (hydrochloride) is an irreversible, potent and selective inhibitor of monoamine oxidase (MAO) A, with K i values of 0.054 and 58μM for MAO-A and MAO-B, and IC 50 values of 0.0012 and 1.9μM, respectively.

  • GC15384 structure
    GC15384Harmane
    CAS: 486-84-0
    Purity: >99.50%

    endogenous ligand for imidazoline binding sites

  • GC16824 structure
    GC16824Pargyline (hydrochloride)
    CAS: 306-07-0
    Purity: >99.00%

    MAO inhibitor

  • GC17314 structure
    GC17314OG-L002
    CAS: 1357302-64-7
    Purity: >99.50%

    LSD1 inhibitor,potent and specific

  • GC19311 structure
    GC19311Ro 41-1049 hydrochloride
    CAS: 127917-66-2
    Purity: >99.50%

    Ro 41-1049 hydrochloride is a selective, reversible, orally-active MAO-A inhibitor.

  • GC26186 structure
    GC26186PXS-6302 hydrochloride
    CAS: 2584947-79-3
    Purity: >98.00%

    PXS-6302 hydrochloride is a potent and irreversible lysine oxidase (LOX) inhibitor (Bovine LOX: IC 50 = 3.7μM; rh LOXL1: IC 50 = 3.4μM; rh LOXL2: IC 50 = 0.4μM; rh LOXL3: IC 50 = 1.5μM; rh LOXL4: IC 50 = 0.3μM).

  • GC30051 structure
    GC30051Methylene Blue (Basic Blue 9)
    CAS: 61-73-4
    Purity: >99.00%

    Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor.

  • GC30112 structure
    GC30112PAT-1251
    CAS: 2007885-39-2
    Purity: >97.00%

    PAT-1251 is a lysyl oxidase-like 2 (LOXL2; IC 50 =0.71μM) inhibitor.

  • GC30218 structure
    GC30218Minaprine
    CAS: 25905-77-5
    Purity: >98%

    Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

  • GC30362 structure
    GC30362MAO-B-IN-1
    CAS: 1124198-17-9
    Purity: >98%

    MAO-B-IN-1 is an inhibitor of monoamine oxidase B, used for the research of neurological diseases.

  • GC30392 structure
    GC30392Desmethoxyyangonin (Demethoxyyangonin)
    CAS: 15345-89-8
    Purity: >99.00%

    Desmethoxyyangonin (Demethoxyyangonin) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

  • GC30544 structure
    GC30544(2-Chloropyridin-4-yl)methanamine hydrochloride
    CAS: 916210-98-5
    Purity: >98.50%

    (2-Chloropyridin-4-yl)methanamine hydrochloride is a highly selective inhibitor of lysyl oxidase-like protein-2 (LOXL2), with an IC 50 of 126nM.

  • GC30766 structure
    GC30766Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate)
    CAS: 13492-01-8
    Purity: >99.00%

    Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression.

  • GC30773 structure
    GC30773Phenelzine sulfate
    CAS: 156-51-4
    Purity: >99.00%

    Phenelzine sulfate is a monoamine oxidase (MAO) inhibitor.

  • GC30870 structure
    GC30870Nialamide
    CAS: 51-12-7
    Purity: >98%

    Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant.

  • GC30949 structure
    GC30949Minaprine dihydrochloride
    CAS: 25953-17-7
    Purity: >99.50%

    Minaprine dihydrochloride is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

  • GC30963 structure
    GC30963Eprobemide (LIS 630)
    CAS: 87940-60-1
    Purity: >99.50%

    Eprobemide (LIS 630) is a non-competitive reversible inhibitor of monoamine oxidase A.

  • GC30976 structure
    GC30976Modaline sulfate
    CAS: 2856-75-9
    Purity: >98.50%

    Modaline sulfate is a MAO inhibitor, used in the treatment of depression.

  • GC30979 structure
    GC30979Lazabemide (Ro 19-6327)
    CAS: 103878-84-8
    Purity: >99.50%

    Lazabemide (Ro 19-6327) (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM).

  • GC30988 structure
    GC30988TB5
    CAS: 948841-07-4
    Purity: >98%

    A potent and selective MAO-B inhibitor