Safinamide |
Catalog No.GC13016 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 133865-89-1
Sample solution is provided at 25 µL, 10mM.
Safinamide (FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A[1].
Safinamide (FCE 26743) is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide (FCE 26743) is voltage-dependent sodium and calcium channel blocker. Safinamide (FCE 26743) appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals[1].
References:
[1]. Leonetti F, et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916.
[2]. Schapira AH.Safinamide in the treatment of Parkinson's disease.Expert Opin Pharmacother. 2010 Sep;11(13):2261-8.
[3]. Onofrj M, et al. An expert opinion on safinamide in Parkinson's disease.Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25.
[4]. Chazot PL.Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.Curr Opin Investig Drugs. 2007 Jul;8(7):570-9.
[5]. Dal Bo L, et al. Bioassay of safinamide in biological fluids of humans and various animal species.Arzneimittelforschung. 2006;56(12):814-9.http://www.ncbi.nlm.nih.gov/pubmed/17260668
Cas No. | 133865-89-1 | SDF | |
Chemical Name | (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide | ||
Canonical SMILES | CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F | ||
Formula | C17H19FN2O2 | M.Wt | 302.34 |
Solubility | DMSO : 60mg/mL | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 3.3075 mL | 16.5377 mL | 33.0753 mL |
5 mM | 0.6615 mL | 3.3075 mL | 6.6151 mL |
10 mM | 0.3308 mL | 1.6538 mL | 3.3075 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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