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Safinamide

Catalog No.GC13016

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Safinamide Chemical Structure

Cas No.: 133865-89-1

Size Price Stock Qty
5mg
$21.00
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10mM (in 1mL DMSO)
$23.00
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10mg
$29.00
In stock
25mg
$50.00
In stock
50mg
$71.00
In stock
100mg
$99.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of Safinamide

Safinamide (FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A[1].

Safinamide (FCE 26743) is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide (FCE 26743) is voltage-dependent sodium and calcium channel blocker. Safinamide (FCE 26743) appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals[1].

References:
[1]. Leonetti F, et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916.
[2]. Schapira AH.Safinamide in the treatment of Parkinson's disease.Expert Opin Pharmacother. 2010 Sep;11(13):2261-8.
[3]. Onofrj M, et al. An expert opinion on safinamide in Parkinson's disease.Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25.
[4]. Chazot PL.Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.Curr Opin Investig Drugs. 2007 Jul;8(7):570-9.
[5]. Dal Bo L, et al. Bioassay of safinamide in biological fluids of humans and various animal species.Arzneimittelforschung. 2006;56(12):814-9.http://www.ncbi.nlm.nih.gov/pubmed/17260668

Chemical Properties of Safinamide

Cas No. 133865-89-1 SDF
Chemical Name (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide
Canonical SMILES CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F
Formula C17H19FN2O2 M.Wt 302.34
Solubility DMSO : 60mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Safinamide

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.3075 mL 16.5377 mL 33.0753 mL
5 mM 0.6615 mL 3.3075 mL 6.6151 mL
10 mM 0.3308 mL 1.6538 mL 3.3075 mL
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In vivo Formulation Calculator (Clear solution) of Safinamide

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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