Oleuropein aglycone (Synonyms: 3,4-DHPEA-EA) |
Catalog No.GC49815
One-Click Copy Product Info
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A polyphenol with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31773-95-2
Sample solution is provided at 25 µL, 10mM.
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Oleuropein aglycone is a polyphenol and an aglycone form of oleuropein that has been found in extra virgin olive oil and has diverse biological activities.1,2,3,4 It is formed from oleuropein via enzymatic, acidic, or acetyl hydrolysis.1 Dietary administration of oleuropein aglycone (50 mg/kg of food) increases the number of neuronal autophagic vesicles and reverses cognitive deficits in a TgCRND8 transgenic mouse model of Alzheimer’s disease.2 It also decreases cortical and hippocampal levels of histone deacetylase 2 (HDAC2) and restores long-term potentiation in the same model. Oleuropein aglycone increases urinary norepinephrine, as well as interscapular brown adipose tissue epinephrine and UCP1 protein levels, and decreases plasma leptin levels and total abdominal cavity adipose tissue weight in a rat model of high-fat diet-induced obesity.3 It also reduces lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.4
1.Xu, F., Li, Y., Zheng, M., et al.Structure properties, acquisition protocols, and biological activities of oleuropein aglyconeFront. Chem.6239(2018) 2.Cordero, J.G., GarcÍa-Escudero, R., Avila, J., et al.Benefit of oleuropein aglycone for Alzheimer’s disease by promoting autophagyOxid. Med. Cell. Longev.5010741(2018) 3.Oi-Kando, Y., Iwasaki, Y., Nakamura, T., et al.Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-fat-diet-induced obese rats by activating β-adrenergic signalingJ. Nutr. Biochem.40209-218(2017) 4.Impellizzeri, D., Esposito, E., Mazzon, E., et al.The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisyClin. Nutr.30(4)533-540(2011)
| Cas No. | 31773-95-2 | SDF | |
| Synonyms | 3,4-DHPEA-EA | ||
| Canonical SMILES | OC1=CC(CCOC(C[C@@H]2C(C(OC)=O)=CO[C@H](/C2=C/C)O)=O)=CC=C1O | ||
| Formula | C19H22O8 | M.Wt | 378.4 |
| Solubility | Acetonitrile: slightly soluble,Ethanol: slightly soluble w/ sonication | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6427 mL | 13.2135 mL | 26.4271 mL |
| 5 mM | 528.5 μL | 2.6427 mL | 5.2854 mL |
| 10 mM | 264.3 μL | 1.3214 mL | 2.6427 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: An oil
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)