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Alzheimer

Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress.

Products for  Alzheimer

  1. Cat.No. Product Name Information
  2. GC11965 (-)-Huperzine A NMDA receptor antagonist/AChE inhibitor (-)-Huperzine A  Chemical Structure
  3. GC18817 3β-hydroxy-5-Cholestenoic Acid 3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic Acid  Chemical Structure
  4. GC40053 5α,6α-epoxy Cholestanol An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol  Chemical Structure
  5. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil  Chemical Structure
  6. GC40587 8,12-iso-iPF2α-VI 8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids. 8,12-iso-iPF2α-VI  Chemical Structure
  7. GC45378 Alaproclate (hydrochloride)   Alaproclate (hydrochloride)  Chemical Structure
  8. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

    Altenusin  Chemical Structure
  9. GC42796 Amylin (human) (trifluoroacetate salt) Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. Amylin (human) (trifluoroacetate salt)  Chemical Structure
  10. GP10099 amyloid A protein fragment [Homo sapiens] Apolipoproteins related to HDL in plasma amyloid A protein fragment [Homo sapiens]  Chemical Structure
  11. GP10118 Amyloid Beta-Peptide (1-40) (human) Amyloid precursor protein Amyloid Beta-Peptide (1-40) (human)  Chemical Structure
  12. GP10049 Amyloid Beta-Peptide (12-28) (human)

    sequence H2N-VHHQKLVFFAEDVGSNK-OH

    Amyloid Beta-Peptide (12-28) (human)  Chemical Structure
  13. GP10082 Amyloid Beta-peptide (25-35) (human)

    Functional domain of Aβ

    Amyloid Beta-peptide (25-35) (human)  Chemical Structure
  14. GP10046 Amyloid Precursor C-Terminal Peptide

    For beta amyloid generation

    Amyloid Precursor C-Terminal Peptide  Chemical Structure
  15. GP10057 Amyloid β-Peptide (10-20) (human)

    Initiates neurodegeneration in Alzheimer disease

    Amyloid β-Peptide (10-20) (human)  Chemical Structure
  16. GP10094 Amyloid β-peptide (10-35), amide Truncated peptide model Amyloid β-peptide (10-35), amide  Chemical Structure
  17. GP10097 Amyloid β-Protein (1-15)

    Principal component of amyloid

    Amyloid β-Protein (1-15)  Chemical Structure
  18. GC42801 Amyloid-β (1-8) Peptide Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide . Amyloid-β (1-8) Peptide  Chemical Structure
  19. GC42802 Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). Amyloid-β (1-8, A2V) Peptide  Chemical Structure
  20. GC42803 Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt) Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)  Chemical Structure
  21. GP10083 Beta-Amyloid (1-11) Amyloidogenic peptide Beta-Amyloid (1-11)  Chemical Structure
  22. GP10101 Beta-Sheet Breaker Peptide iAβ5

    Peptide which can inhibit amyloidogenesis

    Beta-Sheet Breaker Peptide iAβ5  Chemical Structure
  23. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)  Chemical Structure
  24. GC43274 Citromycetin Citromycetin is a fungal metabolite originally isolated from P. Citromycetin  Chemical Structure
  25. GP10010 COG 133

    ApoE mimetic peptide

    COG 133  Chemical Structure
  26. GC43322 CRANAD 28 CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. CRANAD 28  Chemical Structure
  27. GC49557 Cu-GTSM A copper-containing compound with diverse biological activities Cu-GTSM  Chemical Structure
  28. GC12942 DAPT (GSI-IX)

    γ-secretase inhibitor,potent and specific

    DAPT (GSI-IX)  Chemical Structure
  29. GC45765 Deferiprone-d3 Deferiprone-d3  Chemical Structure
  30. GC43494 DL-threo-PDMP (hydrochloride) DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo (1R,2R) and L-threo (1S,2S) PDMP. DL-threo-PDMP (hydrochloride)  Chemical Structure
  31. GC40018 Donepezil N-oxide Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil. Donepezil N-oxide  Chemical Structure
  32. GC43700 FSB FSB is a fluorescent probe that has been used for the detection of amyloid plaques in human postmortem brain from patients with Alzheimer's disease and of curli amyloid fibers in E. FSB  Chemical Structure
  33. GC43708 Fulvic Acid Fulvic acid is a phenolic acid and fungal metabolite originally isolated from Penicillium. Fulvic Acid  Chemical Structure
  34. GC49493 IRL 1620 (trifluoroacetate salt) A peptide ETB receptor agonist IRL 1620 (trifluoroacetate salt)  Chemical Structure
  35. GC18568 JNJ-40418677 JNJ-40418677  Chemical Structure
  36. GC49461 L-Serine-d7 An internal standard for the quantification of L-serine L-Serine-d7  Chemical Structure
  37. GC45917 Leucettine L41 Leucettine L41  Chemical Structure
  38. GC19221 Leucomethylene blue Mesylate Leucomethylene blue (Mesylate) is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes. Leucomethylene blue Mesylate  Chemical Structure
  39. GC40078 Memantine-d6 (hydrochloride) Memantine-d6 is intended for use as an internal standard for the quantification of memantine by GC- or LC-MS. Memantine-d6 (hydrochloride)  Chemical Structure
  40. GC44225 ML-345

    Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.

    ML-345  Chemical Structure
  41. GP10006 Myelin Basic Protein (68-82), guinea pig

    Myelin Basic Protein

    Myelin Basic Protein (68-82), guinea pig  Chemical Structure
  42. GP10130 Myelin Basic Protein (87-99)

    Encephalitogenic peptide

    Myelin Basic Protein (87-99)  Chemical Structure
  43. GC44416 N-methyl Mesoporphyrin IX A ferrochelatase inhibitor and turn-on biosensor for DNA N-methyl Mesoporphyrin IX  Chemical Structure
  44. GC44399 NIAD-4 NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM). NIAD-4  Chemical Structure
  45. GC44674 Pramlintide (acetate hydrate) Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. Pramlintide (acetate hydrate)  Chemical Structure
  46. GC46208 Propentofylline Propentofylline  Chemical Structure
  47. GC18483 RU-505 RU-505 is an inhibitor of the interaction between amyloid-β (Aβ) and fibrinogen, with a higher efficacy for inhibiting monomeric forms of Aβ bound to fibrinogen over oligomeric forms. RU-505  Chemical Structure
  48. GC12096 Semagacestat (LY450139)

    γ-secretase inhibitor

    Semagacestat (LY450139)  Chemical Structure
  49. GC40068 Setosusin Setosusin is a meroterpenoid fungal metabolite originally isolated from C. Setosusin  Chemical Structure
  50. GC45831 SRI-011381 SRI-011381  Chemical Structure
  51. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. Sulfatides (bovine) (sodium salt)  Chemical Structure
  52. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)  Chemical Structure
  53. GC45137 Valproic Acid Acyl-D-Glucuronide Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid. Valproic Acid Acyl-D-Glucuronide  Chemical Structure

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