Alzheimer

Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress.
Products for Alzheimer
- Cat.No. Product Name Information
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GC11965
(-)-Huperzine A
NMDA receptor antagonist/AChE inhibitor
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GC18817
3β-hydroxy-5-Cholestenoic Acid
3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.
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GC40053
5α,6α-epoxy Cholestanol
An oxysterol and a metabolite of cholesterol produced by oxidation
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GC42584
6-O-desmethyl Donepezil
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
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GC40587
8,12-iso-iPF2α-VI
8,12-iso-iPF2α-VI is an isoprostane produced by non-enzymatic, free radical-induced peroxidative damage to membrane lipids.
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GC45378
Alaproclate (hydrochloride)
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GC40024
Altenusin
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.
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GC42796
Amylin (human) (trifluoroacetate salt)
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.
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GP10099
amyloid A protein fragment [Homo sapiens]
Apolipoproteins related to HDL in plasma
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GP10118
Amyloid Beta-Peptide (1-40) (human)
Amyloid precursor protein
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GP10049
Amyloid Beta-Peptide (12-28) (human)
sequence H2N-VHHQKLVFFAEDVGSNK-OH
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GP10082
Amyloid Beta-peptide (25-35) (human)
Functional domain of Aβ
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GP10046
Amyloid Precursor C-Terminal Peptide
For beta amyloid generation
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GP10057
Amyloid β-Peptide (10-20) (human)
Initiates neurodegeneration in Alzheimer disease
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GP10094
Amyloid β-peptide (10-35), amide
Truncated peptide model
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GP10097
Amyloid β-Protein (1-15)
Principal component of amyloid
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GC42801
Amyloid-β (1-8) Peptide
Amyloid-β (1-8) is a wild-type control for the mutation-containing amyloid-β (1-8, A2V) peptide .
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GC42802
Amyloid-β (1-8, A2V) Peptide
Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V).
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GC42803
Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide.
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GP10083
Beta-Amyloid (1-11)
Amyloidogenic peptide
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GP10101
Beta-Sheet Breaker Peptide iAβ5
Peptide which can inhibit amyloidogenesis
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GC42937
Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand.
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GC43274
Citromycetin
Citromycetin is a fungal metabolite originally isolated from P.
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GP10010
COG 133
ApoE mimetic peptide
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GC43322
CRANAD 28
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.
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GC49557
Cu-GTSM
A copper-containing compound with diverse biological activities
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GC12942
DAPT (GSI-IX)
γ-secretase inhibitor,potent and specific
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GC45765
Deferiprone-d3
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GC43494
DL-threo-PDMP (hydrochloride)
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-threo (1R,2R) and L-threo (1S,2S) PDMP.
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GC40018
Donepezil N-oxide
Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil.
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GC43700
FSB
FSB is a fluorescent probe that has been used for the detection of amyloid plaques in human postmortem brain from patients with Alzheimer's disease and of curli amyloid fibers in E.
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GC43708
Fulvic Acid
Fulvic acid is a phenolic acid and fungal metabolite originally isolated from Penicillium.
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GC49493
IRL 1620 (trifluoroacetate salt)
A peptide ETB receptor agonist
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GC18568
JNJ-40418677
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GC49461
L-Serine-d7
An internal standard for the quantification of L-serine
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GC45917
Leucettine L41
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GC19221
Leucomethylene blue Mesylate
Leucomethylene blue (Mesylate) is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes.
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GC40078
Memantine-d6 (hydrochloride)
Memantine-d6 is intended for use as an internal standard for the quantification of memantine by GC- or LC-MS.
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GC44225
ML-345
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.
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GP10006
Myelin Basic Protein (68-82), guinea pig
Myelin Basic Protein
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GP10130
Myelin Basic Protein (87-99)
Encephalitogenic peptide
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GC44416
N-methyl Mesoporphyrin IX
A ferrochelatase inhibitor and turn-on biosensor for DNA
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GC44399
NIAD-4
NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM).
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GC44674
Pramlintide (acetate hydrate)
Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29.
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GC46208
Propentofylline
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GC18483
RU-505
RU-505 is an inhibitor of the interaction between amyloid-β (Aβ) and fibrinogen, with a higher efficacy for inhibiting monomeric forms of Aβ bound to fibrinogen over oligomeric forms.
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GC12096
Semagacestat (LY450139)
γ-secretase inhibitor
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GC40068
Setosusin
Setosusin is a meroterpenoid fungal metabolite originally isolated from C.
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GC45831
SRI-011381
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GC44968
Sulfatides (bovine) (sodium salt)
Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
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GC44987
TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide.
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GC45137
Valproic Acid Acyl-D-Glucuronide
Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.