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Solasodine (Synonyms: NSC 179187, NSC 178260, Purapuridine, Solancarpidine, Solasod-5-en-3β-ol, (-)-Solasodine)

Catalog No.GC16371 Copy One-Click Copy Product Info

An alkaloid with diverse biological activities

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Solasodine Chemical Structure

Cas No.: 126-17-0

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5mg
$34.00
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10mg
$54.00
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50mg
$135.00
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100mg
$234.00
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Sample solution is provided at 25 µL, 10mM.



Description of Solasodine

Description: IC50 Value: 12.17 ± 3.3 uM (Hela cell line)[1] Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937). in vitro: Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment [2]. in vivo: A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract [2]. intraperitoneal (i.p.) injection of solasodine (25 mg/kg) significantly delayed (p < 0.01) latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. In the MES model, solasodine significantly reduced (p < 0.001) duration of HLTE at 25, 50, and 100 mg/kg, i.p. in a dose-dependent manner [3]. Oral administration (80 mg/kg body wt/day for 30 days) of solasodine (extracted and isolated from the berries of the Solanum xanthocarpum) to intact dogs significantly decreased the epithelial cell height of cauda epididymides [4]. Toxicity: N/A Clinical trial: N/A

Chemical Properties of Solasodine

Cas No. 126-17-0 SDF
Synonyms NSC 179187, NSC 178260, Purapuridine, Solancarpidine, Solasod-5-en-3β-ol, (-)-Solasodine
Chemical Name 5',6a,8a,9-tetramethyl-1,3,4,5,6,6a,6b,7,8,8a,8b,9,11a,12,12a,12b-hexadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol
Canonical SMILES [H]C(C1([H])C(C(C([H])([H])C([H])([H])C2([H])O[H])(C([H])([H])[H])C(C2([H])[H])=C([H])C1([H])[H])([H])C([H])([H])C3([H])[H])(C4([H])[H])C3(C([H])([H])[H])C(C5([H])C([H])([H])[H])([H])C4([H])OC65N([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])C6([H])[H]
Formula C27H43NO2 M.Wt 413.64
Solubility ≥ 20.7 mg/mL in EtOH Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Solasodine

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1 mg 5 mg 10 mg
1 mM 2.4176 mL 12.0878 mL 24.1756 mL
5 mM 483.5 μL 2.4176 mL 4.8351 mL
10 mM 241.8 μL 1.2088 mL 2.4176 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Solasodine

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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