P2X purinergic receptor

PPNDS is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM).

PPADS tetrasodium salta is a non-selective P2X receptor antagonist.

Suramin hexasodium salt is a polysulfonated naphthylurea with various biological activities. Suramin hexasodium salt is a DNA topoisomerase II inhibitor with an IC 50 of 5 μM.

A 438079 is a highly selective P2X7R antagonist, with an IC 50 value of 0.1μM at rat P2X7R.

P2Y11/P2X1 antagonist

P2X receptor antagonist

Potent P2X7 receptor antagonist

A-317491 is a high-affinity and selective antagonist of P2X3 and P2X2/3 receptor activation, with K i values of 22 and 92nM for rat P2X3 and P2X2/3, respectively.

P2X7 antagonist,potent and selective

Human P2X7 antagonist,potent and selective

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

Gefapixant is a P2X3 receptor antagonist

PSB-12062 is a potent, selective, non-competitive (allosteric) antagonist of the ATP-gated P2X4 purinergic receptor (P2X4R), with reported IC₅₀ values of 1.38μM for human P2X4R, 0.928μM for rat P2X4R, and 1.76μM for mouse P2X4R.

CE-224535 (PF-04905428) is a selective P2X7 receptor antagonist.

AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.

A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively.

Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects.

GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2.

Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.

Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively.

JNJ-47965567 is a centrally permeable, high affinity, selective P2X7 antagonist with IC 50 values of 5nM and 10nM for human and mouse P2X7 receptors, respectively.

Selective P2X4 allosteric antagonist

CORM 2 is a carbon monoxide-releasing molecule that can liberate a controlled amount of CO in biological systems and has been developed as a carbon monoxide donor.