P2X purinergic receptor
P2X purinergic receptor is a famliy of ATP-gated cation channels. It is widely distributed in the body and paly an important role in regulation of synaptic transmission, vascular endothelium and nociception etc.
Products for P2X purinergic receptor
- Cat.No. Product Name Information
- GC62560 (E/Z)-Sivopixant (E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM.
- GC15416 2-Methylthioadenosine triphosphate tetrasodium salt 2-Methylthioadenosine triphosphate tetrasodium salt is a non-specific P2-receptor agonist.
- GC13943 5-BDBD P2X4 receptor antagonist
- GC50474 A 317491 sodium salt Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive
- GC17212 A 438079 An antagonist of the nucleotide receptor P2X7
- GC13733 A 438079 hydrochloride An antagonist of the nucleotide receptor P2X7
- GC17870 A 804598 P2X7 antagonist,potent and selective
- GC15434 A 839977 P2X7 antagonist,potent and selective
- GC17710 A-317491 A P2X3 and P2X2/3 receptor antagonist
- GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively.
- GC11842 A-740003 A selective P2X7 antagonist
- GC19022 AF-353 AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
- GC11109 ATP disodium salt P2 purinoceptor agonist
- GC12574 ATPγS tetralithium salt ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A.
- GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively.
- GC17375 AZ 10606120 dihydrochloride Potent P2X7 receptor antagonist
- GC18052 AZ 11645373 Human P2X7 antagonist,potent and selective
- GC31674 AZD9056 hydrochloride AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
- GC60090 BLU-5937
- GC12421 Brilliant blue G-250 Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation.
- GC35567 Bullatine A Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects.
- GC50200 BX 430 Selective P2X4 allosteric antagonist
- GC15898 BzATP triethylammonium salt P2X7 receptor agonist
- GC31157 CE-224535 (PF-04905428) CE-224535 (PF-04905428) is a selective P2X7 receptor antagonist.
- GC62950 Eliapixant Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM.
- GC67895 EVT-401
- GC63444 Filapixant Filapixant is a purinoreceptor antagonist extracted from patent WO2016091776A1, example 348.
-
GC19422
Gefapixant
Gefapixant is a P2X3 receptor antagonist
- GC63838 GSK-1482160 GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor.
- GC36202 GW791343 dihydrochloride GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2.
- GC14207 GW791343 HCl GW791343 HCl is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2.
- GC61565 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
- GC10990 iso-PPADS tetrasodium salt P2 purinoceptors antagonist, specific
- GC12339 Ivermectin NAChR/purinergic P2X4 receptor modulator
- GC64822 JNJ-42253432 JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively.
- GC43931 JNJ-47965567 JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel.
- GC62284 JNJ-55308942 JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM).
- GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II
- GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor
- GC16981 KN-92 phosphate
- GN10747 Lannaconitine
- GC63996 Lu AF27139 Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively).
- GC36613 Minodronic acid Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.
- GC10411 MRS 2219 P2X1 receptor potentiator
- GC11289 NF 023 NF 023 is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
- GC13224 NF 110 P2X3 antagonist
- GC17320 NF 157 P2Y11/P2X1 antagonist
- GC14992 NF 279 P2X1 antagonist
- GC11326 NF 449 NF 449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively.
- GC61401 Oxatomide Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity.
- GC60281 P2X3 antagonist 34 P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC50s of 25?nM, 92?nM and 126?nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively.
-
GC69647
P2X7-IN-2 TFA
P2X7-IN-2 TFA (compound 58) is an inhibitor of the P2X7 receptor. It inhibits the release of IL-Iβ with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for research on autoimmune diseases, inflammation, and cardiovascular diseases.
- GC16659 PPADS tetrasodium salt PPADS tetrasodium salta is a non-selective P2X receptor antagonist.
- GC16342 PPNDS PPNDS is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM).
- GC30805 PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.
- GC13584 Purotoxin 1 P2X3 receptor modulator
-
GC11216
Ro 0437626
P2X1 purinergic receptor antagonist
- GC16330 Ro 51 dual P2X3 and P2X2/3 antagonist
- GC10152 RO-3 homomeric P2X3 and heteromeric P2X2/3 receptor antagonist
- GC16832 Suramin hexasodium salt Suramin hexasodium salt(Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor.
- GC11682 TC-P 262 P2X3 and P2X2/3 receptor antagonist
- GC17355 TNP-ATP triethylammonium salt P2X receptor antagonist