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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X purinergic receptor

P2X purinergic receptor

P2X purinergic receptor is a famliy of ATP-gated cation channels. It is widely distributed in the body and paly an important role in regulation of synaptic transmission, vascular endothelium and nociception etc.

Products for  P2X purinergic receptor

  1. Cat.No. Product Name Information
  2. GC62560 (E/Z)-Sivopixant

    (E/Z)-S-600918

     (E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant Chemical Structure
  3. GC15416 2-Methylthioadenosine triphosphate tetrasodium salt 2-Methylthioadenosine triphosphate tetrasodium salt is a non-specific P2-receptor agonist. 2-Methylthioadenosine triphosphate tetrasodium salt Chemical Structure
  4. GC13943 5-BDBD P2X4 receptor antagonist 5-BDBD Chemical Structure
  5. GC50474 A 317491 sodium salt Selective, high affinity P2X3 and P2X2/3 receptor antagonist; antinociceptive A 317491 sodium salt Chemical Structure
  6. GC17212 A 438079 An antagonist of the nucleotide receptor P2X7 A 438079 Chemical Structure
  7. GC13733 A 438079 hydrochloride An antagonist of the nucleotide receptor P2X7 A 438079 hydrochloride Chemical Structure
  8. GC17870 A 804598 P2X7 antagonist,potent and selective A 804598 Chemical Structure
  9. GC15434 A 839977 P2X7 antagonist,potent and selective A 839977 Chemical Structure
  10. GC17710 A-317491

    A 317491;A317491

     A P2X3 and P2X2/3 receptor antagonist A-317491 Chemical Structure
  11. GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate Chemical Structure
  12. GC11842 A-740003 A selective P2X7 antagonist A-740003 Chemical Structure
  13. GC19022 AF-353

    Ro-4

     AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). AF-353 Chemical Structure
  14. GC11109 ATP disodium salt

    5'-ATP, ATP, NSC 20268

     P2 purinoceptor agonist ATP disodium salt Chemical Structure
  15. GC12574 ATPγS tetralithium salt

    ATPγS

     ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS tetralithium salt Chemical Structure
  16. GC39699 Aurintricarboxylic acid Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid Chemical Structure
  17. GC17375 AZ 10606120 dihydrochloride Potent P2X7 receptor antagonist AZ 10606120 dihydrochloride Chemical Structure
  18. GC18052 AZ 11645373 Human P2X7 antagonist,potent and selective AZ 11645373 Chemical Structure
  19. GC31674 AZD9056 hydrochloride AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. AZD9056 hydrochloride Chemical Structure
  20. GC60090 BLU-5937 BLU-5937 Chemical Structure
  21. GC12421 Brilliant blue G-250

    Acid Blue 90,CBBG,Coomassie Brilliant Blue G-250,NSC 328382

     Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. Brilliant blue G-250 Chemical Structure
  22. GC35567 Bullatine A Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A Chemical Structure
  23. GC50200 BX 430

    Blocker of P2X4 Compound 3.0

     Selective P2X4 allosteric antagonist BX 430 Chemical Structure
  24. GC15898 BzATP triethylammonium salt P2X7 receptor agonist BzATP triethylammonium salt Chemical Structure
  25. GC68824 Camlipixant

    BLU-5937

    Camlipixant (BLU-5937) is an effective, selective, non-competitive and orally active P2X3 homotrimer receptor antagonist with an IC50 of 25 nM for hP2X3 homotrimer. Camlipixant exhibits strong antitussive effects without taste alteration. Camlipixant can be used in the research of unexplained and refractory chronic cough.

     Camlipixant Chemical Structure
  26. GC31157 CE-224535 (PF-04905428)

    PF-04905428

     CE-224535 (PF-04905428) is a selective P2X7 receptor antagonist. CE-224535 (PF-04905428) Chemical Structure
  27. GC62950 Eliapixant Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant Chemical Structure
  28. GC67895 EVT-401

    P2X7 receptor antagonist-1

     EVT-401 Chemical Structure
  29. GC63444 Filapixant

    BAY 1902607

     Filapixant is a purinoreceptor antagonist extracted from patent WO2016091776A1, example 348. Filapixant Chemical Structure
  30. GC19422 Gefapixant

    AF219; MK-7264)

    Gefapixant is a P2X3 receptor antagonist

     Gefapixant Chemical Structure
  31. GC63838 GSK-1482160 GSK-1482160 is an orally available negative allosteric modulator of the P2X7 receptor. GSK-1482160 Chemical Structure
  32. GC36202 GW791343 dihydrochloride GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 dihydrochloride Chemical Structure
  33. GC14207 GW791343 HCl GW791343 HCl is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 HCl Chemical Structure
  34. GC74077 HEI3090 HEI3090 is a P2X7R activator. HEI3090 Chemical Structure
  35. GC61565 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7. Indophagolin Chemical Structure
  36. GC10990 iso-PPADS tetrasodium salt P2 purinoceptors antagonist, specific iso-PPADS tetrasodium salt Chemical Structure
  37. GC12339 Ivermectin

    22,23-dihydro Avermectin B1, L-640,471, MK-933

     NAChR/purinergic P2X4 receptor modulator Ivermectin Chemical Structure
  38. GC64822 JNJ-42253432 JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively. JNJ-42253432 Chemical Structure
  39. GC43931 JNJ-47965567 JNJ-47965567 is a centrally permeable, high affinity, selective P2X7 antagonist with IC50 values of 5nM and 10nM for human and mouse P2X7 receptors, respectively. JNJ-47965567 Chemical Structure
  40. GC62284 JNJ-55308942 JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 Chemical Structure
  41. GC14202 KN-62 Inhibitor of Ca2+/calmodulin-dependent kinase type II KN-62 Chemical Structure
  42. GC15988 KN-92 hydrochloride An inactive control compound for a CaMKII inhibitor KN-92 hydrochloride Chemical Structure
  43. GC16981 KN-92 phosphate KN-92 phosphate Chemical Structure
  44. GN10747 Lannaconitine Lannaconitine Chemical Structure
  45. GC63996 Lu AF27139 Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 Chemical Structure
  46. GC36613 Minodronic acid Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain. Minodronic acid Chemical Structure
  47. GC10411 MRS 2219 P2X1 receptor potentiator MRS 2219 Chemical Structure
  48. GC11289 NF 023 NF 023 is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. NF 023 Chemical Structure
  49. GC13224 NF 110 P2X3 antagonist NF 110 Chemical Structure
  50. GC17320 NF 157 P2Y11/P2X1 antagonist NF 157 Chemical Structure
  51. GC14992 NF 279 P2X1 antagonist NF 279 Chemical Structure
  52. GC11326 NF 449 NF 449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF 449 Chemical Structure
  53. GC71126 NP-1815-PX sodium NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium Chemical Structure
  54. GC61401 Oxatomide Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide Chemical Structure
  55. GC71117 P2X7 receptor antagonist-2 P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC50 value of 6.5-7.5. P2X7 receptor antagonist-2 Chemical Structure
  56. GC69647 P2X7-IN-2 TFA

    P2X7-IN-2 TFA (compound 58) is an inhibitor of the P2X7 receptor. It inhibits the release of IL-Iβ with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for research on autoimmune diseases, inflammation, and cardiovascular diseases.

     P2X7-IN-2 TFA Chemical Structure
  57. GC16659 PPADS tetrasodium salt

    Pyridoxalphosphate6azophenyl2',4'disulfonic acid

     PPADS tetrasodium salta is a non-selective P2X receptor antagonist. PPADS tetrasodium salt Chemical Structure
  58. GC16342 PPNDS PPNDS is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS Chemical Structure
  59. GC30805 PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)

    N-(p-Methylphenylsulfonyl)phenoxazine

     PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4. PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) Chemical Structure
  60. GC13584 Purotoxin 1 P2X3 receptor modulator Purotoxin 1 Chemical Structure
  61. GC11216 Ro 0437626

    P2X1 purinergic receptor antagonist

     Ro 0437626 Chemical Structure
  62. GC16330 Ro 51 dual P2X3 and P2X2/3 antagonist Ro 51 Chemical Structure
  63. GC10152 RO-3 homomeric P2X3 and heteromeric P2X2/3 receptor antagonist RO-3 Chemical Structure
  64. GC16832 Suramin hexasodium salt

    BAY 205, Germanin, NF 060

     Suramin hexasodium salt is a polysulfonated naphthylurea with various biological activities. Suramin hexasodium salt is a DNA topoisomerase II inhibitor with an IC50 of 5 μM. Suramin hexasodium salt Chemical Structure
  65. GC11682 TC-P 262 P2X3 and P2X2/3 receptor antagonist TC-P 262 Chemical Structure
  66. GC17355 TNP-ATP triethylammonium salt P2X receptor antagonist TNP-ATP triethylammonium salt Chemical Structure

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