GLPBio

Phospholipase

Phospholipases are enzymes that catalyze the hydrolysis of phospholipids into fatty acids and other lipid mediators. It plays a variety of roles in tumorgenesis , inflammation and brain disorders etc.

Products Related to Phospholipase(136)

  • GC14521 structure
    GC14521ONO-RS-082
    CAS: 99754-06-0
    Purity: >98%

    reversible inhibitor of Ca2+-independent phospholipase A2

  • GC15877 structure
    GC15877CP 316819
    CAS: 186392-43-8
    Purity: >98%

    Selective glycogen phosphorylase inhibitor

  • GC15888 structure
    GC15888VU 0155069
    CAS: 1130067-06-9
    Purity: >98.00%

    VU 0155069 is a selective phospholipase D1 (PLD1) inhibitor (IC 50 =46nM).

  • GC16115 structure
    GC16115AACOCF3
    CAS: 149301-79-1
    Purity: >98.00%

    AACOCF3 (arachidonyl trifluoromethyl ketone) is a potent inhibitor of cytosolic phospholipase A2 (cPLA2) with an IC 50 value of approximately 10μM. By irreversibly alkylating the enzyme's active site, AACOCF3 blocks the release of arachidonic acid and the subsequent production of pro-inflammatory eicosanoids. AACOCF3 is widely used in the study of inflammatory pathways, neuroinflammation, and lipid signaling mechanisms.

  • GC16286 structure
    GC16286m-3M3FBS
    CAS: 200933-14-8
    Purity: >98.00%

    PLC activator

  • GC16364 structure
    GC16364LY 311727
    CAS: 164083-84-5
    Purity: >98.00%

    secreted phospholipase A2 (sPLA2) inhibitor

  • GC16687 structure
    GC16687(R)-Edelfosine
    CAS: 77286-66-9
    Purity: >99.00%

    (R)-Edelfosine is a synthetic lipid agent belonging to a class of compounds with antitumor and antiparasitic activities. (R)-Edelfosine can induce apoptosis-like cell death in tumor cells by targeting FOF1-ATP synthase on mitochondria and lipid rafts.

  • GC16714 structure
    GC16714PACOCF3
    CAS: 141022-99-3
    Purity: >98.00%

    CPLA2 and iPLA2 inhibitor

  • GC16770 structure
    GC16770Arachidonic Acid Leelamide
    Purity: >98%

    phospholipase A2 inhibitor

  • GC17203 structure
    GC17203Varespladib (LY315920)
    CAS: 172732-68-2
    Purity: >98.00%

    Varespladib (LY315920) is a potent and selective inhibitor of group IIA, nonpancreatic secretory PLA2 (sPLA2) with an IC 50 value of 9nM.

  • GC17420 structure
    GC17420OBAA
    CAS: 221632-26-4
    Purity: >98%

    OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM.

  • GC17684 structure
    GC17684VU 0364739 hydrochloride
    CAS: 1244640-48-9
    Purity: >98%

    phospholipase D2 (PLD2) inhibitor

  • GC17851 structure
    GC17851D609
    CAS: 83373-60-8
    Purity: >98.00%

    A competitive inhibitor of PC-specific PLC

  • GC17889 structure
    GC17889ML 349
    CAS: 890819-86-0
    Purity: >99.00%

    ML 349 is the active-site competitive acyl protein thioesterase 2 (APT2) inhibitor, with K i = 0.120μM.

  • GC17960 structure
    GC17960U 73343
    CAS: 142878-12-4
    Purity: >99.00%

    U 73343 is an inactive analogue of U 73122.

  • GC18039 structure
    GC18039ML 348
    CAS: 899713-86-1
    Purity: >99.50%

    ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC 50 of approximately 210nM, exhibiting 14-fold selectivity for LYPLA1 over LYPLA2.

  • GC18141 structure
    GC18141EA4
    CAS: 389614-94-2
    Purity: >98.50%

    rPLA2 inhibitor

  • GC18305 structure
    GC18305CAY10650
    CAS: 1233706-88-1
    Purity: >98.00%

    CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12nM.

  • GC18559 structure
    GC18559Lysophosphatidylethanolamines (egg)
    CAS: 97281-40-8
    Purity: >98%

    Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2).

  • GC18691 structure
    GC18691CAY10594
    CAS: 1130067-34-3
    Purity: >98%

    CAY10594 is an orally active phospholipase D2 (PLD2) inhibitor (IC 50 =140nM).

  • GC19745 structure
    GC19745hnps-PLA Inhibitor
    CAS: 185298-58-2
    Purity: >98%
  • GC30180 structure
    GC30180ST271
    CAS: 106392-48-7
    Purity: >98.50%

    ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.

  • GC30464 structure
    GC30464Ecopladib (PLA 725)
    CAS: 381683-92-7
    Purity: >98%

    Ecopladib (PLA 725) is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.

  • GC30561 structure
    GC305612-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
    CAS: 137089-36-2
    Purity: >98%

    2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress.