Caspase

Caspase - Proteases - Signaling Pathways | GlpBio

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products Related to Caspase(180)

GC81761 4-Methoxycinnamic acid ethyl ester
CAS: 1929-30-2
Purity: >98.50%
4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found.
GC81846 Nivitol
CAS: 869743-37-3
Purity: >98.00%
Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor.
GC81879 NCP26 TFA
Purity: >99.50%
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).
GN10040 Dehydrocorydaline
CAS: 30045-16-0
Purity: >98.00%
Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.
GN10269 Wedelolactone
CAS: 524-12-9
Purity: >99.50%
GN10564 Ecdysterone
CAS: 5289-74-7
Purity: >99.50%
Ecdysterone is a naturally occurring ecdysone that controls molting (feathering) and metamorphosis in arthropods.
GN10629 5,7-dihydroxychromone
CAS: 31721-94-5
Purity: >99.00%
5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.
GN10686 Ginsenoside Rh2
CAS: 78214-33-2
Purity: >99.50%
GN10801 Senkyunolide I
CAS: 94596-28-8
Purity: >99.50%
Senkyunolide I is a natural phthalide existing in L. chuanxiong and A. sinensis with good blood-brain barrier permeability, which has the potential to become a cardio-cerebral vascular drug candidate.
GC12407 Z-IETD-FMK
CAS: 210344-98-2
Purity: >98.00%
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell-permeable inhibitor of caspase-8.
GC16990 Z-LEHD-FMK
CAS: 210345-04-3
Purity: >98.00%
Z-LEHD-FMK is an irreversible caspase-9 inhibitor.
GC11908 Cisplatin
CAS: 15663-27-1
Purity: >98.00%
Cisplatin, a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC81761	4-Methoxycinnamic acid ethyl ester	1929-30-2	>98.50%
GC81761	4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found.
GC81846	Nivitol	869743-37-3	>98.00%
GC81846	Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor.
GC81879	NCP26 TFA	-	>99.50%
GC81879	NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).
GN10040	Dehydrocorydaline	30045-16-0	>98.00%
GN10040	Dehydrocorydaline is one of the quaternary ammonium alkaloids from Corydalis Rhizoma.
GN10269	Wedelolactone	524-12-9	>99.50%
GN10564	Ecdysterone	5289-74-7	>99.50%
GN10564	Ecdysterone is a naturally occurring ecdysone that controls molting (feathering) and metamorphosis in arthropods.
GN10629	5,7-dihydroxychromone	31721-94-5	>99.00%
GN10629	5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.
GN10686	Ginsenoside Rh2	78214-33-2	>99.50%
GN10801	Senkyunolide I	94596-28-8	>99.50%
GN10801	Senkyunolide I is a natural phthalide existing in L. chuanxiong and A. sinensis with good blood-brain barrier permeability, which has the potential to become a cardio-cerebral vascular drug candidate.
GC12407	Z-IETD-FMK	210344-98-2	>98.00%
GC12407	Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell-permeable inhibitor of caspase-8.
GC16990	Z-LEHD-FMK	210345-04-3	>98.00%
GC16990	Z-LEHD-FMK is an irreversible caspase-9 inhibitor.
GC11908	Cisplatin	15663-27-1	>98.00%
GC11908	Cisplatin, a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors.