Stem Cell

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.

Histone H3K27Me2 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences.

Histone H3K27Me2 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences.

Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol.

Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins.

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.

MoTP, known more formally as 4-(4-morpholinobutylthio)phenol, is used to ablate larval melanocytes in zebrafish in order to study melanocyte regeneration.

MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.

N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.

NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain).

PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.

Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM).

An inhibitor of hedgehog acyltransferase

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.

Valproic acid acyl-D-glucuronide is the major urinary metabolite of valproic acid.

A withanolide with anti-inflammatory and anticancer activities

A TNIK inhibitor

BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor of BODIPY-aminoacetaldehyde (BAAA), a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH) with an Ex/Em of 488/512nm.

A small molecule promotor of hepatocyte differentiation

A neuropeptide with diverse biological activities