BRD 6989 |
| Catalog No.GC50452 |
Cdk8 inhibitor; enhances IL-10 production
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 642008-81-9
Sample solution is provided at 25 µL, 10mM.
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Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C.
Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID:28805801
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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