Home>>Signaling Pathways>> Membrane Transporter/Ion Channel>> Ionophore>>Calcium Ionophore I

Calcium Ionophore I (Synonyms: CA 1001, ETH 1001)

Catalog No.GC10949

Ca2+-selective ionophore

Products are for research use only. Not for human use. We do not sell to patients.

Calcium Ionophore I Chemical Structure

Cas No.: 58801-34-6

Size Price Stock Qty
5mg
$79.00
In stock
10mg
$149.00
In stock
25mg
$329.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Calcium Ionophore I, also known as CA 1001 or ETH 1001, is a Ca2+-selective ionophore [1][2].

Ionophores can selectively change the ionic permeability of a membrane and therefore can be used to mimic the properties of the ion carriers normally found in biological membranes and to study membrane function [2].

Calcium Ionophore I is a Ca2+-selective neutral carrier. In Ca2+ loaded IOVs derived from human RBCs, ETH 1001 promoted Ca2+ flux across RBC membranes. The amount of Ca2+ in cells treated with ETH 1001 was significantly higher than in control cells. In the presence of external Ca2+, ETH 1001 was capable of transporting Ca2+ into RBCs [3]. CA 1001 was also used to construction of the Ca2+-selective membrane microelectrode [4][5].

References:
[1]Dagostino M, Lee CO.  Neutral carrier Na+- and Ca2+-selective microelectrodes for intracellular application. Biophys J. 1982 Dec;40(3):199-207.
[2]Caroni P, Gazzotti P, Vuilleumier P, et al.  Ca2+ transport mediated by a synthetic neutral Ca2+ -ionophore in biological membranes. Biochim Biophys Acta. 1977 Nov 1;470(3):437-45.
[3]Hinds TR, Vincenzi FF.  The effect of ETH 1001 on ion fluxes across red blood cell membranes. Cell Calcium. 1985 Jun;6(3):265-79.
[4]Lücke A, Lehmenkühler A, Speckmann EJ.  The influence of the convulsant pentylenetetrazol on Ca2+-selective microelectrodes (neutral carrier ETH 1001). J Neurosci Methods. 1989 Aug;29(2):139-42.
[5]Lee MH, Yoo CL, Lee JS, et al.  Tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. Anal Chem. 2002 Jun 1;74(11):2603-7.

Chemical Properties

Cas No. 58801-34-6 SDF
Synonyms CA 1001, ETH 1001
Chemical Name (17R,18R)-diethyl 13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontane-1,34-dioate
Canonical SMILES C[C@H]([C@H](OCC(N(CCCCCCCCCCCC(OCC)=O)C)=O)C)OCC(N(C)CCCCCCCCCCCC(OCC)=O)=O
Formula C38H72N2O8 M.Wt 684.99
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.4599 mL 7.2994 mL 14.5988 mL
5 mM 0.292 mL 1.4599 mL 2.9198 mL
10 mM 0.146 mL 0.7299 mL 1.4599 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Calcium Ionophore I

Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for Calcium Ionophore I

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.