Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11 [1] [2]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control.
In Vivo, Anti-IL11 Antibody (X203) (20 mg/kg, i.p., twice a week for 2.5 weeks starting from 6 weeks of age) improves renal function and increases lifespan in a mouse model of Alport syndrome (AS)[2].
In Vitro, Anti-IL11 Antibody (X203) (20 μM; 48 h) effectively inhibits IL11-induced downstream STAT3 phosphorylation in Bleomycin -induced mouse nucleus pulposus (NP) cells[1].
References:
[1]. Chen R, et al. Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis. Int Immunopharmacol. 2025 Nov 14;165:115450.
[2]. Widjaja AA, et al. A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. J Am Soc Nephrol. 2022 Apr;33(4):718-730.
In Vivo, Anti-IL11 Antibody (X203) (20 mg/kg, i.p., twice a week for 2.5 weeks starting from 6 weeks of age) improves renal function and increases lifespan in a mouse model of Alport syndrome (AS)[2].
In Vitro, Anti-IL11 Antibody (X203) (20 μM; 48 h) effectively inhibits IL11-induced downstream STAT3 phosphorylation in Bleomycin -induced mouse nucleus pulposus (NP) cells[1].
References:
[1]. Chen R, et al. Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis. Int Immunopharmacol. 2025 Nov 14;165:115450.
[2]. Widjaja AA, et al. A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. J Am Soc Nephrol. 2022 Apr;33(4):718-730.