Stem Cell

RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor.

CAD204520 dihydrochloride, a SERCA inhibitor ( IC 50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).

FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC 50 1540 μM, NHERF1 PDZ2 IC 50 160 μM, and Frizzled-7-Dishevelled PDZ complex K i 10 μM.

ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

PAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC 50 of <6.95 μM.

SkQR1 hydroxide is a mitochondrial targeted antioxidant.

Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties.

XL-418 is an orally active dual Akt and p70S6K inhibitor with IC 50 s of 1 nM for Akt1 and 2 nM for p70S6K.

Tovophyllin A is an orally active xanthonoid compound.

ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.

MST3-IN-1 TFA (Compound LD-1) is a selective and orally active MST3 inhibitor, with an IC 50 of 122.4 nM.

KY19334 is a CXXC5-DVL inhibitor.

MR24 TFA, a G-5555 derivative, is a mammalian STE20-like ( MST ) kinase inhibitor.

Taladegib (LY2940680) hydrochloride is a Smoothened ( SMO ) antagonist.

WAY-362692 is a secreted frizzled-related protein ( sFRP-1 ) inhibitor ( IC 50 of 0.02 μM), targeting the netrin domain of sFRP-1.

Remigromig (EYE-103; MK-3000) is a humanized dual-target monoclonal antibody that targets LRP5 and FZD4.

Evabosmig (AGA2118) is a humanized bispecific monoclonal antibody targeting sclerostin ( SOST/sclerostin ) and DKK1.

SNX3-IN-1 is a sorting nexin 3 (SNX3) inhibitor.

YAP/TEAD-IN-2 (Compound T-1) is a YAP/TEAD inhibitor.

SLD1121 is an agonist of the Wnt/β-catenin signaling pathway that enhances Wnt signaling by targeting LRP6 ( K d: 4.52-7.49 nM).

(R,S)-YAP-TEAD-IN-2 is the racemic mixture of YAP-TEAD-IN-2.

Zocilurtatug (ZL-1310 Antibody) is a human monoclonal antibody targeting DLL3.

SGC-CK1γ-1 is a potent and selective probe for the CK1γ subfamily.

Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.