GLPBio

FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

Products Related to FXR & LXR(82)

  • GC19448 structure
    GC19448RGX-104 Hydrochloride
    CAS: 610318-03-1
    Purity: >99.50%

    RGX-104 Hydrochloride is an orally active liver X receptor (LXR) agonist that modulates innate immunity by activating the transcription of the apolipoprotein E (ApoE) gene.

  • GC19892 structure
    GC19892Sodium chenodeoxycholate
    CAS: 2646-38-0
    Purity: >98.00%

    A primary bile acid

  • GC30565 structure
    GC30565BAR502
    CAS: 1612191-86-2
    Purity: >98.00%

    A dual agonist of GP-BAR1 and FXR

  • GC30842 structure
    GC30842Androsterone (5α-Androstan-3α-ol-17-one)
    CAS: 53-41-8
    Purity: >95.00%

    Androsterone (5α-Androstan-3α-ol-17-one) is a metabolite of testosterone that modulates the susceptibility of an epilepsy seizure.

  • GC31314 structure
    GC31314Nagilactone B
    CAS: 19891-51-1
    Purity: >98.00%

    Nagilactone B is a liver X receptor (LXR) agonist.

  • GC31331 structure
    GC31331GSK2033
    CAS: 1221277-90-2
    Purity: >99.00%

    GSK2033 is a potent LXR antagonist, with IC 50 values of 310nM and 83nM for LXRα and LXRβ, respectively.

  • GC31372 structure
    GC31372BMS-779788 (EXEL04286652)
    CAS: 918348-67-1
    Purity: >98.00%

    BMS-779788 (EXEL04286652) is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.

  • GC31386 structure
    GC31386(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)
    CAS: 1268244-88-7
    Purity: >98%

    (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.

  • GC31395 structure
    GC31395PX20606 trans racemate (PX-102 trans racemate)
    CAS: 1268244-85-4
    Purity: >98.50%

    PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

  • GC32054 structure
    GC32054Rovazolac
    CAS: 1454288-88-0
    Purity: >99.50%

    Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

  • GC32459 structure
    GC32459XL041 (BMS-852927)
    CAS: 1256918-39-4
    Purity: >99.00%

    XL041 (BMS-852927) (BMS-852927) is an LXRβ-selective agonist.

  • GC32742 structure
    GC32742INT-767
    CAS: 1000403-03-1
    Purity: >98.00%

    INT-767 is a potent dual agonist of the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5), with EC 50 values of 30nM and 630nM, respectively.

  • GC32801 structure
    GC32801AZ876
    CAS: 898800-26-5
    Purity: >99.00%

    An LXR agonist

  • GC33673 structure
    GC3367324-Hydroxycholesterol
    CAS: 30271-38-6
    Purity: >98.00%

    24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

  • GC34686 structure
    GC34686Nidufexor
    CAS: 1773489-72-7
    Purity: >98.50%

    Nidufexor is an orally available farnesoid X receptor (FXR) agonist with an EC 50 value of 25nM.

  • GC34965 structure
    GC34965(20S)-Protopanaxatriol
    CAS: 34080-08-5
    Purity: >98.00%

    (20S)-Protopanaxatriol is a metabolite derived from ginsenosides, possessing diverse biological activities and pharmacological effects.

  • GC36499 structure
    GC36499LXRβ agonist-2
    CAS: 1949801-52-8
    Purity: >98%

    LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis.

  • GC37525 structure
    GC37525RGX-104 free Acid
    CAS: 610318-54-2
    Purity: >99.50%
  • GC37630 structure
    GC37630Sevelamer
    CAS: 52757-95-6
    Purity: >98%

    Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.

  • GC39535 structure
    GC39535Yamogenin
    CAS: 512-06-1
    Purity: >98.00%

    Yamogenin (Neodiosgenin) is a diastereomer of diosgenin.

  • GC40024 structure
    GC40024Altenusin
    CAS: 31186-12-6
    Purity: >98.00%

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

  • GC40053 structure
    GC400535α,6α-epoxy Cholestanol
    CAS: 1250-95-9
    Purity: >95.00%

    5α,6α-epoxy Cholestanol is a cholesterol derivative that can be catalytically generated by the cytochrome P450 enzyme system in mitochondria or induced during lipid peroxidation. 5α,6α-epoxy Cholestanol can regulate the biosynthesis of bile acids and induce the differentiation and death of tumor cells.

  • GC40571 structure
    GC4057124(S),25-epoxy Cholesterol
    CAS: 77058-74-3
    Purity: >95.00%

    24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.

  • GC40911 structure
    GC40911Glycine-β-muricholic Acid
    CAS: 66225-78-3
    Purity: >98.00%

    Glycine-β-muricholic Acid is an effective, stable, and arginine-selective oral bioactive FXR inhibitor. It is the glycine-bound form of the murine primary bile acid β-muricholic acid.