GLPBio

Crotonoside

Catalog No.: GC38412Purity:>98.00%Synonyms: 2-Hydroxyadenosine, Isoguanine riboside, Isoguanosine, NSC 12161
COASDSData Sheet
Crotonoside is a FLT3 and HDAC3/6 inhibitor that can be used to study acute myeloid leukemia (AML).

Products are for research use only. Not for human use. We do not sell to patients.

Crotonoside
Cas No.: 1818-71-9
1mgIn Stock
$36.00
1
5mgIn Stock
$61.00
1
10mgIn Stock
$102.00
1
20mgIn Stock
$183.00
1
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Description

Crotonoside is a FLT3 and HDAC3/6 inhibitor that can be used to study acute myeloid leukemia (AML)[1].

Crotonoside (50μM, 24h) induced late apoptosis in about 50% AML cell line MV4-11[1]. Crotonoside (7.5, 15, or 30μM; 48h) significantly induced AML cell apoptosis in a dose-dependent manner[2].

Crotonoside (25, 50, or 100mg/kg; 20 days; i.p.) ameliorated the severity of collagen-induced arthritis (CIA) in mice[3]. Compared with the rabbits in the normal saline (NS) group, the group given Crotonoside (4.5mg/kg, intravenous injection) effectively prolonged the time of aconitine-induced arrhythmias and significantly reduced the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF)[4].

References:
[1] Li YZ, Yu S, Yan PA, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Nov 11;8(61):103087.
[2] Ma C, Liu P, Cui S, et al. The identification of APOBEC3G as a potential prognostic biomarker in acute myeloid leukemia and a possible drug target for crotonoside. Molecules. 2022 Sep 7;27(18):5804.
[3] Lin SC, Lin CC, Li S, et al. Alleviation of collagen-induced arthritis by crotonoside through modulation of dendritic cell differentiation and activation. Plants. 2020 Nov 10;9(11):1535.
[4] Liu Z, Jia Y, Song L, et al. Antiarrhythmic effect of crotonoside by regulating sodium and calcium channels in rabbit ventricular myocytes. Life sciences. 2020 Mar 1;244:117333.

Protocol

Cell experiment [1]:

Cell lines

Acute myeloid leukemia (AML) cell line MV4-11

Preparation Method

MV4-11 cells were treated with Crotonoside (25, 50, and 100μM) or 0.1% DMSO for 24 hours. After treatment MV4-11 cells were harvested, washed with PBS and stained for apoptosis using the Annexin V-fluorescein isothiocyanate (FITC) Apoptosis Detection Kit.

Reaction Conditions

25, 50, and 100μM; 16 or 24 hours

Applications

Crotonoside (50μM, 24h) induced late apoptosis in about 50% AML cells.
Animal experiment [2]:

Animal models

Collagen-induced arthritic (CIA) mouse model

Preparation Method

Crotonoside was dissolved in a solvent of 10% DMSO and 90% glyceryl trioctanoate. The mice were randomly divided into four groups (n = 6 per group), including normal, CIA vehicle control, Methotrexate (MTX)-treated and Crotonoside-treated mice at 25, 50, or 100mg/kg. MTX (0.5mg/kg) and Crotonoside treatments were intraperitoneally administered once daily from day 21 to day 41 after the first immunization, whereas vehicle control mice received the solvent.

Dosage form

25, 50, or 100mg/kg; 20 days; i.p.

Applications

Crotonoside ameliorated the severity of collagen-induced arthritis (CIA) in mice.

References:
[1] Li YZ, Yu S, Yan PA, et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Nov 11;8(61):103087.
[2] Lin SC, Lin CC, Li S, et al. Alleviation of collagen-induced arthritis by crotonoside through modulation of dendritic cell differentiation and activation. Plants. 2020 Nov 10;9(11):1535.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1818-71-9
Synonyms
2-Hydroxyadenosine, Isoguanine riboside, Isoguanosine, NSC 12161
SMILES
OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC(C(N)=N3)=C2NC3=O)O1)O)O
Molecular Formula
C10H13N5O5
Molecular Weight
283.24
Solubility
DMSO: 25 mg/mL (88.26 mM)
Storage
Store at -20°C,protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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