TGF-β / Smad Signaling
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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Research Areas
Products Related to TGF-β / Smad Signaling(394)
- GC79187TAT-Epsilon-V1-2 TFAPurity: >99.50%
TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor.
- GC81302Asciminib-NH2CAS: 3106065-83-9Purity: >97.00%
Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As [1] .
- GC81341IKVAVC acetatePurity: >98.00%
IKVAVC acetate is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus.
- GC81351Endotrophin (Mus musculus) TFAPurity: >96.50%
Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice.
- GC81352Anti-ALK7 AntibodyPurity: >97.50%
Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7.
- GC81353PF-07868489Purity: >99.00%
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9.
- GC815427-O-Galloyl-D-sedoheptuloseCAS: 233690-85-2Purity: >98.00%
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.
- GC81672Senkyunolide BCAS: 93236-67-0Purity: >98.00%
Senkyunolide B is a phthalide found in Angelica sinensis.
- GC81880OSU-2S TFAPurity: >98.00%
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).
- GC81892Vevorisertib tetrahydrochloridePurity: >98.00%
Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.
- GD096703,3-Dimethyl-1-butanolCAS: 624-95-3Purity: >99.50%
3,3-Dimethyl-1-butanolは経口阻害剤であり、微生物でトリメチルアミン（TMA）の産生を阻害し、異なる微生物のTMAリアーゼを抑制する。
- GN10378OxymatrineCAS: 16837-52-8Purity: >98.00%
Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens.
- GN10534AsiaticosideCAS: 16830-15-2Purity: >98.00%
AsiaticosideはCentella asiaticaから抽出された五環式トリテルペノイド配糖体である。
- GC11499Enzastaurin (LY317615)CAS: 170364-57-5Purity: >99.50%
Enzastaurin (LY317615)はPKCβのATP競合性と選択的な阻害剤であり、IC 50 値は6nMである。
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC79187 | TAT-Epsilon-V1-2 TFA | - | >99.50% | |
TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor. | ||||
| GC79188 | TAS1440 | 2098585-77-2 | >98.00% | |
TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC 50 of 4.8 nM. | ||||
| GC79707 | ST1072 | 1402703-50-7 | >98.00% | |
ST1072 is an inhibitor of CerS4 and CerS6. | ||||
| GC80859 | RepSox-d 5 | - | >98.00% | |
RepSox -d 5 (E-616452-d 5 ) is the deuterium labeled RepSox. | ||||
| GC81302 | Asciminib-NH2 | 3106065-83-9 | >97.00% | |
Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As [1] . | ||||
| GC81341 | IKVAVC acetate | - | >98.00% | |
IKVAVC acetate is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus. | ||||
| GC81342 | CMF9 | - | >98.50% | |
CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction. | ||||
| GC81350 | THR-123 TFA | - | >99.50% | |
THR-123 TFA is an orally active ALK3 peptide agonist. | ||||
| GC81351 | Endotrophin (Mus musculus) TFA | - | >96.50% | |
Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. | ||||
| GC81352 | Anti-ALK7 Antibody | - | >97.50% | |
Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7. | ||||
| GC81353 | PF-07868489 | - | >99.00% | |
PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9. | ||||
| GC81542 | 7-O-Galloyl-D-sedoheptulose | 233690-85-2 | >98.00% | |
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. | ||||
| GC81672 | Senkyunolide B | 93236-67-0 | >98.00% | |
Senkyunolide B is a phthalide found in Angelica sinensis. | ||||
| GC81880 | OSU-2S TFA | - | >98.00% | |
OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720). | ||||
| GC81892 | Vevorisertib tetrahydrochloride | - | >98.00% | |
Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation. | ||||
| GC90543 | EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt) | - | >95.00% | |
PKC阻害剤 | ||||
| GD09670 | 3,3-Dimethyl-1-butanol | 624-95-3 | >99.50% | |
3,3-Dimethyl-1-butanolは経口阻害剤であり、微生物でトリメチルアミン（TMA）の産生を阻害し、異なる微生物のTMAリアーゼを抑制する。 | ||||
| GN10336 | Daphnetin | 486-35-1 | >99.00% | |
| GN10378 | Oxymatrine | 16837-52-8 | >98.00% | |
Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens. | ||||
| GN10444 | 12-O-tetradecanoyl phorbol-13-acetate | 16561-29-8 | >98.00% | |
PKC活性化剤 | ||||
| GN10463 | Chelerythrine | 34316-15-9 | >98.00% | |
| GN10534 | Asiaticoside | 16830-15-2 | >98.00% | |
AsiaticosideはCentella asiaticaから抽出された五環式トリテルペノイド配糖体である。 | ||||
| GC11499 | Enzastaurin (LY317615) | 170364-57-5 | >99.50% | |
Enzastaurin (LY317615)はPKCβのATP競合性と選択的な阻害剤であり、IC 50 値は6nMである。 | ||||
| GC15281 | K-252c | 85753-43-1 | >99.00% | |
K-252c、Nocardiopsis sp.から分離されたスタウロスポリン類似体。 | ||||