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KEAP1-Nrf2

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The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products Related to KEAP1-Nrf2(81)

  • GB10587 structure
    GB10587Gingerenone A
    CAS: 128700-97-0
    Purity: >98.00%

    Gingerenone A is an orally active Nrf2-Gpx4 activator with an EC 50 value of 24μM.

  • GC11302 structure
    GC11302Hinokitiol
    CAS: 499-44-5
    Purity: >98.00%

    Hinokitiol is a naturally occurring tropolone compound from the Formosan cypress with antibacterial and anticancer properties.

  • GC11572 structure
    GC11572Bardoxolone methyl
    CAS: 218600-53-4
    Purity: >98.50%

    Bardoxolone methyl is an effective activator of the antioxidant and anti-inflammatory response mediated by nuclear factor erythroid 2-related factor 2 (Nrf2), and it is also an inhibitor of the NF-κB pathway.

  • GC12545 structure
    GC125452-HBA
    CAS: 131359-24-5
    Purity: >98.00%

    indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

  • GC12821 structure
    GC12821Oltipraz
    CAS: 64224-21-1
    Purity: >99.50%

    Oltipraz is an HIF-1α inhibitor (IC 50 =10μM) and an Nrf2 activator.

  • GC13058 structure
    GC13058NK 252
    CAS: 1414963-82-8
    Purity: >98.00%

    NK 252 is an Nrf2 activator.

  • GC14016 structure
    GC14016Sulforaphane
    CAS: 4478-93-7
    Purity: >98.00%

    Sulforaphane is an isothiocyanate that is present naturally in cruciferous vegetables with anti-oxidant, anti-inflammatory, and anti-bacterial effects.

  • GC14352 structure
    GC14352TAT 14
    CAS: 1362661-34-4
    Purity: >98.00%

    Nrf2 activator

  • GC14787 structure
    GC14787Curcumin
    CAS: 458-37-7
    Purity: >98.00%

    A yellow pigment with diverse biological activities

  • GC15355 structure
    GC153552-Trifluoromethyl-2'-methoxychalcone
    CAS: 1309371-03-6
    Purity: >98.00%

    Nrf2 activator

  • GC15371 structure
    GC15371Bardoxolone
    CAS: 218600-44-3
    Purity: >98.00%

    An anti-inflammatory compound that activates Nrf2/ARE signaling

  • GC15457 structure
    GC15457Pyridoxine
    CAS: 65-23-6
    Purity: >99.50%

    A 4-methanol form of vitamin B 6

  • GC15605 structure
    GC15605Ezetimibe
    CAS: 163222-33-1
    Purity: >99.00%

    Ezetimibe is a selective cholesterol absorption inhibitor with IC 50 values of 50μM for lung cancer cell (A549), human embryonic kidney cells (HEK293) and 30μM for melanoma cell (A375) for 48h.

  • GC16120 structure
    GC16120AI-3
    CAS: 882288-28-0
    Purity: >98%

    Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor

  • GC16625 structure
    GC16625CDDO-TFEA
    CAS: 932730-52-4
    Purity: >99.50%

    Nrf2 activator

  • GC17393 structure
    GC17393Pyridoxine HCl
    CAS: 58-56-0
    Purity: >99.50%

    Pyridoxine HCl is the hydrochloride form of vitamin B6 that functions as an antioxidant.

  • GC19254 structure
    GC19254ML385
    CAS: 846557-71-9
    Purity: >98.00%

    ML385 is a cell-active NRF2 inhibitor (IC 50 =1.9μM).

  • GC25351 structure
    GC25351Dimethyl itaconate
    CAS: 617-52-7
    Purity: >99.00%

    Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.

  • GC31321 structure
    GC31321KI696
    CAS: 1799974-70-1
    Purity: >99.00%

    KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.

  • GC31648 structure
    GC316484-Octyl Itaconate
    CAS: 3133-16-2
    Purity: >98.00%

    4-Octyl Itaconate (4-OI) is a cell-permeable itaconate derivative.

  • GC31691 structure
    GC31691(+)-DHMEQ
    CAS: 287194-41-6
    Purity: >99.50%

    (+)-DHMEQ is an activator of antioxidant transcription factor Nrf2.

  • GC31783 structure
    GC31783Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)
    CAS: 2150-43-8
    Purity: >98.00%

    Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea.

  • GC32723 structure
    GC32723CDDO-Im (RTA-403)
    CAS: 443104-02-7
    Purity: >98.00%

    CDDO-Im (RTA-403) is a synthetic triterpenoid that activates Nuclear factor erythroid 2–related factor 2 (Nrf2) signaling by binding to Kelch-like ECH-associated protein 1 (Keap1), thereby inhibiting Nrf2 degradation and increasing its protein levels.

  • GC33092 structure
    GC33092Hesperin
    CAS: 4430-35-7
    Purity: >98.00%

    An isothiocyanate with diverse biological activities