GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(358)

  • GC73968 structure
    GC73968Pim-1 kinase inhibitor 8
    CAS: 916038-47-6
    Purity: >99.00%

    Pim-1 kinase inhibitor 8 (화합물 12)는 14.3 nM의 IC50을 갖는 Pim-1 kinase의 강력한 억제제이다.

  • GC74116 structure
    GC74116Pyk2-IN-2
    CAS: 1271418-15-5
    Purity: >98.00%

    Pyk2-IN-2 (복합 13j)은 억제 제야의 Pyk2 with an IC50 FAK 산화효소의 0.608 μ M.

  • GC74190 structure
    GC74190Hydrochlorothiazide-13C6
    CAS: 1261396-79-5
    Purity: >99.00%

    Hydrochlorothiazide-13C6 는 13C 표시된 디클로로티아진이다.

  • GC74326 structure
    GC74326MPSD TFA
    Purity: >98.00%

    MPSD TFA (MARCKS-ED TFA)는 MPSD의 TFA 소금 형태입니다.

  • GC74417 structure
    GC74417PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA
    Purity: >98.00%

    PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA은 사용 할 수 있는 합성 펩 티 드의 행동의 메커니즘을 연구하는 PKC θ다.

  • GC74419 structure
    GC74419N-myristoyl-RKRTLRRL
    CAS: 152246-40-7
    Purity: >99.00%

    N-myristoyl-RKRTLRRL은 PKC 기판의 결합을 억제한다.

  • GC74516 structure
    GC74516Bintrafusp alfa
    CAS: 1918149-01-5
    Purity: >97.00%

    Bintrafusp alfa (M 7824) 는 TGF- 베타 RII의 세포 외 구조 도메인과 절차적 세포 사멸 배합체를 차단하는 사람 IgG1 단일 클론 항체가 융합된 일류 이중 기능 융합 단백질이다.

  • GC74573 structure
    GC74573Livmoniplimab
    CAS: 2412004-88-5
    Purity: >99.00%

    Livmoniplimab (ABBV-151) 는 활성 TGF- 베타 1 방출을 억제하는 GARP/TGF- 베타 1에 대한 단일 클론 항체입니다.

  • GC74617 structure
    GC74617SHR-1701
    CAS: 2891860-17-4
    Purity: >99.00%

    SHR-1701 (Retlirafusp alfa) 는 암 연구에 사용되는 표적 PD-L1 및 TGF- 베타의 이중 기능 융합 단백질입니다.

  • GC79115 structure
    GC79115ROCK2-IN-12
    CAS: 3086603-12-2
    Purity: >98.00%

    ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC 50 of 7.0 nM for ROCK2 over ROCK1.

  • GC79116 structure
    GC79116NRL-1049 dihydrochloride
    CAS: 1973494-17-5
    Purity: >99.00%

    NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 ( ROCK2 ) inhibitor with an IC 50 of 0.59 μM.

  • GC79186 structure
    GC79186(1S,4R)-CC-90005
    Purity: >99.50%

    (1S,4R)-CC-90005 is the (1S,4R)-enantiomer of CC-90005.

  • GC79187 structure
    GC79187TAT-Epsilon-V1-2 TFA
    Purity: >99.50%

    TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor.

  • GC79188 structure
    GC79188TAS1440
    CAS: 2098585-77-2
    Purity: >98.00%

    TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC 50 of 4.8 nM.

  • GC79707 structure
    GC79707ST1072
    CAS: 1402703-50-7
    Purity: >98%

    ST1072 is an inhibitor of CerS4 and CerS6.

  • GC80859 structure
    GC80859RepSox-d 5
    Purity: >98%

    RepSox -d 5 (E-616452-d 5 ) is the deuterium labeled RepSox.

  • GC81302 structure
    GC81302Asciminib-NH2
    CAS: 3106065-83-9
    Purity: >97.00%

    Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As [1] .

  • GC81341 structure
    GC81341IKVAVC acetate
    Purity: >98.00%

    IKVAVC acetate is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus.

  • GC81342 structure
    GC81342CMF9
    Purity: >98.50%

    CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction.

  • GC81350 structure
    GC81350THR-123 TFA
    Purity: >99.50%

    THR-123 TFA is an orally active ALK3 peptide agonist.

  • GC81351 structure
    GC81351Endotrophin (Mus musculus) TFA
    Purity: >96.50%

    Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice.

  • GC81352 structure
    GC81352Anti-ALK7 Antibody
    Purity: >97.50%

    Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7.

  • GC81353 structure
    GC81353PF-07868489
    Purity: >99.00%

    PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.