GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(358)

  • GC81672 structure
    GC81672Senkyunolide B
    CAS: 93236-67-0
    Purity: >98%

    Senkyunolide B is a phthalide found in Angelica sinensis.

  • GC81880 structure
    GC81880OSU-2S TFA
    Purity: >98.00%

    OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).

  • GC81892 structure
    GC81892Vevorisertib tetrahydrochloride
    Purity: >98.00%

    Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.

  • GC90543 structure
    GC90543EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt)
    Purity: >95.00%

    PKC 억제제

  • GD09670 structure
    GD096703,3-Dimethyl-1-butanol
    CAS: 624-95-3
    Purity: >99.50%

    3,3-Dimethyl-1-butanol은 미생물에 의한 트리메틸아민(TMA) 생산을 억제하고 다양한 미생물 TMA 라이아제를 억제하는 경구용 억제제이다.

  • GN10336 structure
    GN10336Daphnetin
    CAS: 486-35-1
    Purity: >99.00%
  • GN10378 structure
    GN10378Oxymatrine
    CAS: 16837-52-8
    Purity: >98.00%

    Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens.

  • GN10444 structure
    GN1044412-O-tetradecanoyl phorbol-13-acetate
    CAS: 16561-29-8
    Purity: >98.00%

    PKC 활성제

  • GN10463 structure
    GN10463Chelerythrine
    CAS: 34316-15-9
    Purity: >98%
  • GN10534 structure
    GN10534Asiaticoside
    CAS: 16830-15-2
    Purity: >98.00%

    Asiaticoside는 센텔라 아시아티카에서 추출한 오리고리테르펜 사포시드이다.

  • GC11499 structure
    GC11499Enzastaurin (LY317615)
    CAS: 170364-57-5
    Purity: >99.50%

    엔자스타우린(LY317615)(LY317615)은 강력하고 선택적인 PKCβ입니다. PKCα에 비해 6배 내지 20배 선택성을 나타내는 6nM의 IC50을 갖는 억제제, PKCγ 및 PKCε

  • GC15281 structure
    GC15281K-252c
    CAS: 85753-43-1
    Purity: >99.00%

    K-252c, Nocardiopsis sp.에서 분리된 스타우로스포린 유사체.

  • GC15420 structure
    GC15420ICP 103
    Purity: >98%

    Protein kinase inhibitor

  • GC15431 structure
    GC15431GF 109203X (Bisindolylmaleimide I)
    CAS: 133052-90-1
    Purity: >99.00%

    GF 109203X는 단백질 키나제 C의 선택적 억제제로 α와 β1 아형에 선택적이다. 단백질 키나제 C의 α, β1, δ, ε, ζ 아형에 대한 IC50 값은 각각 0.0084, 0.0180, 0.210, 0.132, 5.8 μM이다.

  • GC15520 structure
    GC15520Sotrastaurin (AEB071)
    CAS: 425637-18-9
    Purity: >99.50%

    Sotrastaurin (AEB071)은 PKCθ, PKCβ, PKCα, PKCη, PKCδ 및 PKCε에 대한 Ki 값이 각각 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM, 3.2 nM인 강력하고 경구 활성인 단백질 키나아제 C (PKC) 억제제이다.

  • GC16907 structure
    GC16907Go 6983
    CAS: 133053-19-7
    Purity: >99.00%

    Go 6983은 PKCα, PKCβ, PKCγ, PKCδ 및 PKCμ에 대한 IC 50 값이 각각 7nM, 7nM, 6nM, 10nM, 20μM인 범PKC 억제제이다.

  • GC14701 structure
    GC14701Zoledronic Acid
    CAS: 118072-93-8
    Purity: >99.00%

    Zoledronic Acid 은 3세대 질소 함유 비스포스포네이트계 골흡수 억제제이다.

  • GC17936 structure
    GC17936GSK269962A
    CAS: 850664-21-0
    Purity: >99.50%

    GSK269962A(GSK 269962)는 재조합 인간 ROCK1 및 ROCK2에 대해 각각 1.6 및 4nM의 IC50을 갖는 강력한 ROCK 억제제입니다.

  • GC12790 structure
    GC12790Pirfenidone
    CAS: 53179-13-8
    Purity: >98.00%

    Pirfenidone (AMR69)은 구강활성을 가진 항섬유화 약물로 섬유세포에서의 화학 항섬유제 CCL2와 CCL12의 생성을 완화시킨다.

  • GC16354 structure
    GC16354Dequalinium Chloride
    CAS: 522-51-0
    Purity: >98.00%

    Dequalinium Chloride는 Apamin에 민감한 K+ 채널의 선택적 차단제입니다.

  • GC17322 structure
    GC17322Ro 31-8220
    CAS: 125314-64-9
    Purity: >98%

    Ro 31-8220은 PKCα, PKCβI, PKCβII, PKCγ, PKCε 및 쥐 뇌 PKC에 대해 IC50이 각각 5, 24, 14, 27, 24 및 23nM인 강력한 PKC 억제제입니다.

  • GC10496 structure
    GC10496Midostaurin (PKC412)
    CAS: 120685-11-2
    Purity: >98.00%

    Midostaurin (PKC412)은 구강 투여가 가능한 다중 표적 타이로신 키나아제 억제제로 FLT3, KIT, PDGFR, VEGFR 등 다수의 키나아제를 억제한다 (IC50 = 22-500nM).