GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(394)

  • GC79187 structure
    GC79187TAT-Epsilon-V1-2 TFA
    Purity: >99.50%

    TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor.

  • GC79188 structure
    GC79188TAS1440
    CAS: 2098585-77-2
    Purity: >98.00%

    TAS1440 is an orally active LSD1/KDM1A inhibitor with a human IC 50 of 4.8 nM.

  • GC79707 structure
    GC79707ST1072
    CAS: 1402703-50-7
    Purity: >98.00%

    ST1072 is an inhibitor of CerS4 and CerS6.

  • GC80859 structure
    GC80859RepSox-d 5
    Purity: >98.00%

    RepSox -d 5 (E-616452-d 5 ) is the deuterium labeled RepSox.

  • GC81302 structure
    GC81302Asciminib-NH2
    CAS: 3106065-83-9
    Purity: >97.00%

    Asciminib-NH2 is a BCR-ABL ligand and can be used for the synthesis of PROTACs, such as P19As [1] .

  • GC81341 structure
    GC81341IKVAVC acetate
    Purity: >98.00%

    IKVAVC acetate is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus.

  • GC81342 structure
    GC81342CMF9
    Purity: >98.50%

    CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction.

  • GC81350 structure
    GC81350THR-123 TFA
    Purity: >99.50%

    THR-123 TFA is an orally active ALK3 peptide agonist.

  • GC81351 structure
    GC81351Endotrophin (Mus musculus) TFA
    Purity: >96.50%

    Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice.

  • GC81352 structure
    GC81352Anti-ALK7 Antibody
    Purity: >97.50%

    Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7.

  • GC81353 structure
    GC81353PF-07868489
    Purity: >99.00%

    PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98.00%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.

  • GC81672 structure
    GC81672Senkyunolide B
    CAS: 93236-67-0
    Purity: >98.00%

    Senkyunolide B is a phthalide found in Angelica sinensis.

  • GC81880 structure
    GC81880OSU-2S TFA
    Purity: >98.00%

    OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).

  • GC81892 structure
    GC81892Vevorisertib tetrahydrochloride
    Purity: >98.00%

    Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.

  • GC90543 structure
    GC90543EGFR Peptide (human, mouse) (myristoylated) (trifluoroacetate salt)
    Purity: >95.00%

    PKC 억제제

  • GD09670 structure
    GD096703,3-Dimethyl-1-butanol
    CAS: 624-95-3
    Purity: >99.50%

    3,3-Dimethyl-1-butanol은 미생물에 의한 트리메틸아민(TMA) 생산을 억제하고 다양한 미생물 TMA 라이아제를 억제하는 경구용 억제제이다.

  • GN10336 structure
    GN10336Daphnetin
    CAS: 486-35-1
    Purity: >99.00%
  • GN10378 structure
    GN10378Oxymatrine
    CAS: 16837-52-8
    Purity: >98.00%

    Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens.

  • GN10444 structure
    GN1044412-O-tetradecanoyl phorbol-13-acetate
    CAS: 16561-29-8
    Purity: >98.00%

    PKC 활성제

  • GN10463 structure
    GN10463Chelerythrine
    CAS: 34316-15-9
    Purity: >98.00%
  • GN10534 structure
    GN10534Asiaticoside
    CAS: 16830-15-2
    Purity: >98.00%

    Asiaticoside는 센텔라 아시아티카에서 추출한 오리고리테르펜 사포시드이다.

  • GC11499 structure
    GC11499Enzastaurin (LY317615)
    CAS: 170364-57-5
    Purity: >99.50%

    엔자스타우린(LY317615)(LY317615)은 강력하고 선택적인 PKCβ입니다. PKCα에 비해 6배 내지 20배 선택성을 나타내는 6nM의 IC50을 갖는 억제제, PKCγ 및 PKCε

  • GC15281 structure
    GC15281K-252c
    CAS: 85753-43-1
    Purity: >99.00%

    K-252c, Nocardiopsis sp.에서 분리된 스타우로스포린 유사체.