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Home >> Signaling Pathways >> Endocrinology and Hormones >> FXR & LXR

FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

Products for  FXR & LXR

  1. Cat.No. Product Name Information
  2. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure
  3. GC34965 (20S)-Protopanaxatriol An active ginsenoside metabolite (20S)-Protopanaxatriol Chemical Structure
  4. GC14972 22(R)-hydroxy Cholesterol endogenous agonist for LXRs 22(R)-hydroxy Cholesterol Chemical Structure
  5. GC18270 22(S)-hydroxy Cholesterol A synthetic oxysterol and LXR modulator 22(S)-hydroxy Cholesterol Chemical Structure
  6. GC17827 24(R)-hydroxy Cholesterol

    LXRα and LXRβ nuclear receptors activator

     24(R)-hydroxy Cholesterol Chemical Structure
  7. GC40571 24(S),25-epoxy Cholesterol

    24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.

     24(S),25-epoxy Cholesterol Chemical Structure
  8. GC18076 24(S)-hydroxy Cholesterol

    LXRα and LXRβ nuclear receptors activator

     24(S)-hydroxy Cholesterol Chemical Structure
  9. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol Chemical Structure
  10. GC13431 24α-methyl Cholesterol 24α-methyl Cholesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects. 24α-methyl Cholesterol Chemical Structure
  11. GC13887 25(R)-27-hydroxy Cholesterol 25(R)-27-hydroxy Cholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. 25(R)-27-hydroxy Cholesterol Chemical Structure
  12. GC11700 25(S)-27-hydroxy Cholesterol liver x receptors (LXRα and LXRβ) activator 25(S)-27-hydroxy Cholesterol Chemical Structure
  13. GC40053 5α,6α-epoxy Cholestanol An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol Chemical Structure
  14. GC17059 Acetyl Podocarpic Acid Anhydride LXR agonist Acetyl Podocarpic Acid Anhydride Chemical Structure
  15. GC40024 Altenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  16. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  17. GC32801 AZ876 An LXR agonist AZ876 Chemical Structure
  18. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502 Chemical Structure
  19. GC42943 Bischloroanthrabenzoxocinone Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone Chemical Structure
  20. GC31372 BMS-779788 (EXEL04286652) BMS-779788 (EXEL04286652) is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ. BMS-779788 (EXEL04286652) Chemical Structure
  21. GC48426 CAY10771 A dual agonist of FXR and PPARδ CAY10771 Chemical Structure
  22. GC17985 Chenodeoxycholic Acid nuclear receptors(FXR) activator Chenodeoxycholic Acid Chemical Structure
  23. GC48424 Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide A metabolite of CDCA Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide Chemical Structure
  24. GC49853 Chenodeoxycholic Acid 3-Glucuronide A metabolite of CDCA Chenodeoxycholic Acid 3-Glucuronide Chemical Structure
  25. GC48595 Chenodeoxycholic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid MaxSpec® Standard Chemical Structure
  26. GC68212 Chenodeoxycholic acid-13C Chenodeoxycholic acid-13C Chemical Structure
  27. GC47076 Chenodeoxycholic Acid-d4 A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid-d4 Chemical Structure
  28. GC18212 Cilofexor Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Cilofexor Chemical Structure
  29. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 Chemical Structure
  30. GC10755 Fexaramine farnesoid X receptor agonist Fexaramine Chemical Structure
  31. GC40911 Glycine-β-muricholic Acid Glycine-β-muricholic Acid, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders. Glycine-β-muricholic Acid Chemical Structure
  32. GC45466 Glyco-Obeticholic Acid   Glyco-Obeticholic Acid Chemical Structure
  33. GC31331 GSK2033

    An antagonist of LXRα and LXRβ

     GSK2033 Chemical Structure
  34. GC48610 GSK3987 A dual agonist of LXRα and LXRβ GSK3987 Chemical Structure
  35. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  36. GC16964 GW3965 An orally-active agonist of LXRα and LXRβ GW3965 Chemical Structure
  37. GC17696 GW3965 HCl GW3965 HCl is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively. GW3965 HCl Chemical Structure
  38. GC10975 GW4064 GW4064, as a synthetic FXR agonist, was used for treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease. GW4064 Chemical Structure
  39. GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. INT-767 Chemical Structure
  40. GC65936 Larsucosterol (trimethylamine) Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1. Larsucosterol (trimethylamine) Chemical Structure
  41. GC36499 LXRβ agonist-2 LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis. LXRβ agonist-2 Chemical Structure
  42. GC13954 LXR-623 Liver X-receptor agonist LXR-623 Chemical Structure
  43. GC19421 LY2562175

    LY2562175 is a potent and selective?FXR?agonist with an?EC50?of 193 nM

     LY2562175 Chemical Structure
  44. GC31314 Nagilactone B

    Nagilactone B is a liver X receptor (LXR) agonist.

     Nagilactone B Chemical Structure
  45. GC69541 NDB

    NDB is a selective antagonist of human FXRα (hFXRα) that can effectively regulate the transcription of downstream genes of FXRα. NDB can be used in anti-diabetes research.

     NDB Chemical Structure
  46. GC34686 Nidufexor

    An FXR partial agonist

     Nidufexor Chemical Structure
  47. GC14158 Obeticholic Acid A FXR agonist with anticholeretic activity Obeticholic Acid Chemical Structure
  48. GC31395 PX20606 trans racemate (PX-102 trans racemate) PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively. PX20606 trans racemate (PX-102 trans racemate) Chemical Structure
  49. GC19448 RGX-104 RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. RGX-104 Chemical Structure
  50. GC37525 RGX-104 free Acid RGX-104 free Acid Chemical Structure
  51. GC32054 Rovazolac Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. Rovazolac Chemical Structure
  52. GN10024 Saikosaponin A Saikosaponin A Chemical Structure
  53. GC37630 Sevelamer Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin. Sevelamer Chemical Structure
  54. GC11885 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin. Sevelamer HCl Chemical Structure
  55. GC45567 SR 1903   SR 1903 Chemical Structure
  56. GC13680 SR-9243 inverse agonist of LXR SR-9243 Chemical Structure
  57. GC14638 SR9238 inverse agonist of the two LXR isoforms, LXRα and LXRβ SR9238 Chemical Structure
  58. GC10596 T0901317 Liver X receptor agonist,potent and selective T0901317 Chemical Structure
  59. GC44999 Tauro-α-muricholic Acid (sodium salt) Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid. Tauro-α-muricholic Acid (sodium salt) Chemical Structure
  60. GC49011 Tauro-α-muricholic Acid-d4 (sodium salt) An internal standard for the quantification of tauro-α-muricholic acid Tauro-α-muricholic Acid-d4 (sodium salt) Chemical Structure
  61. GC45000 Tauro-β-muricholic Acid (sodium salt) Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM. Tauro-β-muricholic Acid (sodium salt) Chemical Structure
  62. GC49012 Tauro-β-muricholic Acid-d4 (sodium salt) An internal standard for the quantification of tauro-β-muricholic acid Tauro-β-muricholic Acid-d4 (sodium salt) Chemical Structure
  63. GC44998 Tauro-Obeticholic Acid Tauro-obeticholic acid is a taurine-conjugated form of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid. Tauro-Obeticholic Acid Chemical Structure
  64. GC19363 Tropifexor Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. Tropifexor Chemical Structure
  65. GC32459 XL041 (BMS-852927) XL041 (BMS-852927) (BMS-852927) is an LXRβ-selective agonist. XL041 (BMS-852927) Chemical Structure
  66. GC10760 XL335 XL335 (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM. XL335 Chemical Structure

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