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Home >> Signaling Pathways >> Endocrinology and Hormones >> FXR & LXR

FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

Products for  FXR & LXR

  1. Cat.No. Product Name Information
  2. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure
  3. GC34965 (20S)-Protopanaxatriol

    20(S)-APPT, 20(S)-PPT

     An active ginsenoside metabolite (20S)-Protopanaxatriol Chemical Structure
  4. GC14972 22(R)-hydroxy Cholesterol

    Narthesterol

     endogenous agonist for LXRs 22(R)-hydroxy Cholesterol Chemical Structure
  5. GC18270 22(S)-hydroxy Cholesterol

    22β-hydroxy Cholesterol

     A synthetic oxysterol and LXR modulator 22(S)-hydroxy Cholesterol Chemical Structure
  6. GC17827 24(R)-hydroxy Cholesterol

    24-Epicerebrosterol

    LXRα and LXRβ nuclear receptors activator

     24(R)-hydroxy Cholesterol Chemical Structure
  7. GC40571 24(S),25-epoxy Cholesterol

    24(S)-24,25-EC

    24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.

     24(S),25-epoxy Cholesterol Chemical Structure
  8. GC18076 24(S)-hydroxy Cholesterol

    Cerebrosterol

    LXRα and LXRβ nuclear receptors activator

     24(S)-hydroxy Cholesterol Chemical Structure
  9. GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol Chemical Structure
  10. GC13431 24α-methyl Cholesterol

    Campesterol,NSC 224330

     24α-methyl Cholesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects. 24α-methyl Cholesterol Chemical Structure
  11. GC13887 25(R)-27-hydroxy Cholesterol

    (25R)-26-hydroxy cholesterol

     25(R)-27-hydroxy Cholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. 25(R)-27-hydroxy Cholesterol Chemical Structure
  12. GC11700 25(S)-27-hydroxy Cholesterol

    (25S)-26-hydroxy cholesterol

     liver x receptors (LXRα and LXRβ) activator 25(S)-27-hydroxy Cholesterol Chemical Structure
  13. GC91680 4-Acetamido Antipyrine

    4-AAAP,NSC 331807

     4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole . 4-Acetamido Antipyrine Chemical Structure
  14. GC40053 5α,6α-epoxy Cholestanol

    NSC 18176

     An oxysterol and a metabolite of cholesterol produced by oxidation 5α,6α-epoxy Cholestanol Chemical Structure
  15. GC17059 Acetyl Podocarpic Acid Anhydride

    APD

     LXR agonist Acetyl Podocarpic Acid Anhydride Chemical Structure
  16. GC40024 Altenusin

    Alutenusin

    Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

     Altenusin Chemical Structure
  17. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    Androkinin, NSC 9898

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  18. GC32801 AZ876 An LXR agonist AZ876 Chemical Structure
  19. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502 Chemical Structure
  20. GC42943 Bischloroanthrabenzoxocinone

    BABX, (―)-Bischloroanthrabenzoxocinone

     Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone Chemical Structure
  21. GC31372 BMS-779788 (EXEL04286652)

    EXEL04286652; XL-652; BMS-788

     BMS-779788 (EXEL04286652) is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ. BMS-779788 (EXEL04286652) Chemical Structure
  22. GC48426 CAY10771 A dual agonist of FXR and PPARδ CAY10771 Chemical Structure
  23. GC17985 Chenodeoxycholic Acid

    CDCA

     nuclear receptors(FXR) activator Chenodeoxycholic Acid Chemical Structure
  24. GC48424 Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide

    CDCA-24G, CDCA-24-glucuronide

     A metabolite of CDCA Chenodeoxycholic Acid 24-Acyl-β-D-Glucuronide Chemical Structure
  25. GC49853 Chenodeoxycholic Acid 3-Glucuronide

    CDCA-3G, CDCA-3-Glucuronide

     A metabolite of CDCA Chenodeoxycholic Acid 3-Glucuronide Chemical Structure
  26. GC68212 Chenodeoxycholic acid-13C

    CDCA-13C

     Chenodeoxycholic acid-13C Chemical Structure
  27. GC47076 Chenodeoxycholic Acid-d4

    CDCA-d4

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid-d4 Chemical Structure
  28. GC18212 Cilofexor

    GS-9674

     Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Cilofexor Chemical Structure
  29. GC90700 Dendrogenin A

    A selective LXR modulator and ChEH inhibitor

     Dendrogenin A Chemical Structure
  30. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 Chemical Structure
  31. GC10755 Fexaramine farnesoid X receptor agonist Fexaramine Chemical Structure
  32. GC71185 FXR agonist 3 FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 Chemical Structure
  33. GC69138 FXR agonist 5

    FXR agonist 5 (compound 1) is a type of FXR activator. FXR agonist 5 can be used to study diseases or disorders caused by metabolic inflammation.

     FXR agonist 5 Chemical Structure
  34. GC71156 FXR antagonist 1 FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist (IC50=2.1 μM). FXR antagonist 1 Chemical Structure
  35. GC40911 Glycine-β-muricholic Acid

    Gly-MCA, GβMCA

     Glycine-β-muricholic Acid, a bile acid, is a potent, sable, intestine-selective and oral bioactive farnesoid X receptor (FXR) inhibitor that may be a candidate for the treatment of metabolic disorders. Glycine-β-muricholic Acid Chemical Structure
  36. GC45466 Glyco-Obeticholic Acid

    Obeticholic Acid Glycine Conjugate

       Glyco-Obeticholic Acid Chemical Structure
  37. GC31331 GSK2033

    An antagonist of LXRα and LXRβ

     GSK2033 Chemical Structure
  38. GC48610 GSK3987 A dual agonist of LXRα and LXRβ GSK3987 Chemical Structure
  39. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  40. GC16964 GW3965 An orally-active agonist of LXRα and LXRβ GW3965 Chemical Structure
  41. GC17696 GW3965 HCl GW3965 HCl is a selective, orally active, nonsteroidal agonist for liver X receptors (LXR). GW3965 HCl Chemical Structure
  42. GC10975 GW4064 GW4064, as a synthetic FXR agonist, was used for treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease. GW4064 Chemical Structure
  43. GC73416 HEC96719 HEC96719 is a selective and orally active tricyclic farnesoid X receptor (FXR) agonist with EC50 values of 1.37 and 1.55 nM, respectively. HEC96719 Chemical Structure
  44. GC92033 HPG1860 HPG1860 is a farnesoid X receptor (FXR) agonist. HPG1860 Chemical Structure
  45. GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. INT-767 Chemical Structure
  46. GC65936 Larsucosterol (trimethylamine)

    DUR-928 (trimethylamine)

     Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1. Larsucosterol (trimethylamine) Chemical Structure
  47. GC36499 LXRβ agonist-2 LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis. LXRβ agonist-2 Chemical Structure
  48. GC13954 LXR-623

    WAY-252623

     Liver X-receptor agonist LXR-623 Chemical Structure
  49. GC19421 LY2562175

    LY2562175 is a potent and selective?FXR?agonist with an?EC50?of 193 nM

     LY2562175 Chemical Structure
  50. GC31314 Nagilactone B

    Nagilactone B is a liver X receptor (LXR) agonist.

     Nagilactone B Chemical Structure
  51. GC69541 NDB

    NDB is a selective antagonist of human FXRα (hFXRα) that can effectively regulate the transcription of downstream genes of FXRα. NDB can be used in anti-diabetes research.

     NDB Chemical Structure
  52. GC34686 Nidufexor

    Nidufexor

    An FXR partial agonist

     Nidufexor Chemical Structure
  53. GC14158 Obeticholic Acid

    INT 747, Obeticholic Acid

     Obeticholic Acid (INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid) is a potent, selective and orally active farnesoid X receptor(FXR) agonist with an EC50 of 99nM. Obeticholic Acid Chemical Structure
  54. GC70996 Omesdafexor Omesdafexor is a FXR agonist. Omesdafexor Chemical Structure
  55. GC31395 PX20606 trans racemate (PX-102 trans racemate) PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively. PX20606 trans racemate (PX-102 trans racemate) Chemical Structure
  56. GC19448 RGX-104

    Abequolixron hydrochloride

     RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. RGX-104 Chemical Structure
  57. GC37525 RGX-104 free Acid

    Abequolixron

     RGX-104 free Acid Chemical Structure
  58. GC32054 Rovazolac Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. Rovazolac Chemical Structure
  59. GN10024 Saikosaponin A Saikosaponin A Chemical Structure
  60. GC37630 Sevelamer Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin. Sevelamer Chemical Structure
  61. GC11885 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin. Sevelamer HCl Chemical Structure
  62. GC19892 Sodium chenodeoxycholate

    CDCA, NSC 681066

    A primary bile acid

     Sodium chenodeoxycholate Chemical Structure
  63. GC45567 SR 1903   SR 1903 Chemical Structure
  64. GC13680 SR-9243 inverse agonist of LXR SR-9243 Chemical Structure
  65. GC14638 SR9238 inverse agonist of the two LXR isoforms, LXRα and LXRβ SR9238 Chemical Structure
  66. GC10596 T0901317 Liver X receptor agonist,potent and selective T0901317 Chemical Structure
  67. GC44999 Tauro-α-muricholic Acid (sodium salt)

    Tauro-α-muricholate, TαMCA

     Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid. Tauro-α-muricholic Acid (sodium salt) Chemical Structure
  68. GC49011 Tauro-α-muricholic Acid-d4 (sodium salt)

    Tauro-β-muricholate-d4, TβMCA-d4

     An internal standard for the quantification of tauro-α-muricholic acid Tauro-α-muricholic Acid-d4 (sodium salt) Chemical Structure
  69. GC45000 Tauro-β-muricholic Acid (sodium salt)

    Tauro-β-muricholate； TβMCA

     Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM. Tauro-β-muricholic Acid (sodium salt) Chemical Structure
  70. GC49012 Tauro-β-muricholic Acid-d4 (sodium salt)

    Tauro-β-muricholate-d4, TβMCA-d4

     An internal standard for the quantification of tauro-β-muricholic acid Tauro-β-muricholic Acid-d4 (sodium salt) Chemical Structure
  71. GC45806 Tauro-ω-muricholic Acid (sodium salt)

    T-ω-MCA, TOMCA

     A neuropeptide with diverse biological activities Tauro-ω-muricholic Acid (sodium salt) Chemical Structure
  72. GC44998 Tauro-Obeticholic Acid

    Obeticholic Acid Taurine Conjugate, Tauro 6-Ethylchenodeoxycholic Acid

     Tauro-obeticholic acid is a taurine-conjugated form of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid. Tauro-Obeticholic Acid Chemical Structure
  73. GC91042 Tauro-Obeticholic Acid (sodium salt)

    An active metabolite of obeticholic acid

     Tauro-Obeticholic Acid (sodium salt) Chemical Structure
  74. GC19363 Tropifexor

    LJN452

     Tropifexor is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. Tropifexor Chemical Structure
  75. GC32459 XL041 (BMS-852927)

    BMS-852927

     XL041 (BMS-852927) (BMS-852927) is an LXRβ-selective agonist. XL041 (BMS-852927) Chemical Structure
  76. GC10760 XL335

    FXR 450, Turofexorate Isopropyl, WAY-362450

     XL335 (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM. XL335 Chemical Structure
  77. GC39535 Yamogenin

    Neodiosgenin, NSC 226132

     Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin Chemical Structure
  78. GC91037 ZLY28

    An FXR agonist and inhibitor of FABP1

     ZLY28 Chemical Structure

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