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Altenusin (Synonyms: Alutenusin)

Catalog No.GC40024

Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.

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Altenusin Chemical Structure

Cas No.: 31186-12-6

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.[1][2] It inhibits Src kinase with an IC50 value of 20 nM.[3]  Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. [1] It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day. Altenusin also has antioxidant and antifungal properties.

Reference:
[1]. Chua, S.W., Cornejo, A., van Eersel, J., et al. The polyphenol altenusin inhibits in vitro fibrillization of tau and reduces induced tau pathology in primary neurons. ACS Chem. Neurosci. 8(4), 743-751 (2017).
[2]. Zheng, Z., Zhao, Z., Li, S., et al. Altenusin, a nonsteroidal microbial metabolite, attenuates nonalcoholic fatty liver disease by activating the farnesoid X receptor. Mol. Pharmacol. 92(4), 425-436 (2017).
[3]. Oyama, M., Xu, Z., Lee, K.-H., et al. Fungal metabolites as potent protein kinase inhibitors: Identification of a novel metabolite and novel activities of known metabolites. Lett. Drug. Des. Discov. 100(1), 24-29 (2004).

Chemical Properties

Cas No. 31186-12-6 SDF
Synonyms Alutenusin
Chemical Name 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid
Canonical SMILES COC1=CC(C2=C(C)C=C(O)C(O)=C2)=C(C(O)=O)C(O)=C1
Formula C15H14O6 M.Wt 290.3
Solubility DMSO: soluble,Ethanol: soluble,Methanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.4447 mL 17.2236 mL 34.4471 mL
5 mM 0.6889 mL 3.4447 mL 6.8894 mL
10 mM 0.3445 mL 1.7224 mL 3.4447 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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