Ferroptosis

An HMG-CoA reductase inhibitor

Liproxstatin-1 is a highly efficient and selective ferroptosis inhibitor with an IC 50 of 22nM.

synthetic analog of coenzyme Q10 (CoQ10)

Zileuton, a benzothiophene N-hydroxyurea, is an oral inhibitor of 5-Lipoxygenase.

Rosiglitazone is an orally active peroxisome proliferator-activated receptor gamma (PPARγ) selective agonist that selectively activates chimeras containing the PPARγ ligand-binding domain (LBD) but not PPARα and PPARδ with an EC 50 of 60 nM and a K d of 40nM.

naturally occuring scent chemical

Erastin is a ferroptosis activator.

A DPP-4 inhibitor

Sulfasalazine is a sulfonamide drug.

Withaferin A is a steroidal lactone generally obtained from Withania somnifera (L.) Dunal, commonly known as Ashwagandha.

Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC 50 values of 6 nM and 22 nM, respectively.

Non-essential amino acid

Nordihydroguaiaretic acid is a potent 5-lipoxygenase (5-LOX) inhibitor with an IC 50 value of 8μM.

Chelating agent

ML-210 is a prodrug that selectively inhibits GPX4 covalently with an EC 50 of 30nM.

ML385 is a cell-active NRF2 inhibitor (IC 50 =1.9μM).

Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties.

Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.

Cefotiam hexetil hydrochloride (CTM-HE) is an oral third-generation cephalosporin, which is a prodrug of cefotiam, but has no anti-bacterial property. Cefotiam is an antibiotic.

NCOA4 - 9a is an inhibitor of ferritinophagy that inhibits erastin-induced ferroptosis, with an EC 50 value of 0.29μM.

FIN56, a novel ferroptosis inducer, triggers ferroptosis by increasing the degradation of GPX4 .

Butylhydroxyanisole (Butylated hydroxyanisole) (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative.