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Home >> Signaling Pathways >> Metabolism >> Ferroptosis

Ferroptosis

Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.

Products for  Ferroptosis

  1. Cat.No. Product Name Information
  2. GC50345 Liproxstatin-1 hydrochloride Potent ferroptosis inhibitor Liproxstatin-1 hydrochloride Chemical Structure
  3. GC11633 Lovastatin An inhibitor of HMG-CoA reductase Lovastatin Chemical Structure
  4. GC44214 ML-162

    ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

     ML-162 Chemical Structure
  5. GC18705 ML-210

    A GPX4 inhibitor

     ML-210 Chemical Structure
  6. GC19254 ML385

    ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor.

     ML385 Chemical Structure
  7. GC68479 MMRi62 MMRi62 Chemical Structure
  8. GC33469 NADPH tetracyclohexanamine

    A reduced form of NADP+

     NADPH tetracyclohexanamine Chemical Structure
  9. GC34058 NADPH tetrasodium salt

    A reduced form of NADP+

     NADPH tetrasodium salt Chemical Structure
  10. GC11008 Necrostatin-1

    A RIP1 kinase inhibitor

     Necrostatin-1 Chemical Structure
  11. GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor Nordihydroguaiaretic acid Chemical Structure
  12. GC47870 Pantothenate Kinase Inhibitor A reversible inhibitor of pantothenate kinase Pantothenate Kinase Inhibitor Chemical Structure
  13. GC12205 PD 146176

    PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1.

     PD 146176 Chemical Structure
  14. GC10538 Pifithrin-α (PFTα) Pifithrin-α(PFT-α) is a p53 inhibitor. Pifithrin-αwidely used in neuroscience to block neuronal apoptotic cell death. Pifithrin-αis also a potent stimulant of aryl hydrocarbon receptor (AhR).. Pifithrin-α (PFTα) Chemical Structure
  15. GC14948 Pioglitazone Pioglitazone (PIO) is a thiazolidinedione antidiabetic drug that acts as a PPARγ agonist. The EC50 of PPARγ in human and mouse was 0.93 and 0.99 µM, respectively.. Pioglitazone Chemical Structure
  16. GC61187 Pioglitazone D4 An internal standard for the quantification of pioglitazone Pioglitazone D4 Chemical Structure
  17. GC11152 Pioglitazone HCl A PPARγ agonist Pioglitazone HCl Chemical Structure
  18. GC36926 Piperazine Erastin Piperazine Erastin Chemical Structure
  19. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities Piperlongumine Chemical Structure
  20. GC14538 Pravastatin sodium A potent HMG-CoA reductase inhibitor Pravastatin sodium Chemical Structure
  21. GC12086 PRIMA-1 A re-activator of the apoptotic function of mutant p53 proteins PRIMA-1 Chemical Structure
  22. GN10361 Pseudolaric Acid B Pseudolaric Acid B Chemical Structure
  23. GC49691 PSP A two-photon fluorescent probe for H2Sn PSP Chemical Structure
  24. GC48029 RC363 An inhibitor of ferroptosis RC363 Chemical Structure
  25. GC48030 RC574 An inhibitor of ferroptosis RC574 Chemical Structure
  26. GC16444 Rosiglitazone

    A PPARγ agonist

     Rosiglitazone Chemical Structure
  27. GC44851 Rosiglitazone (potassium salt) Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone (potassium salt) Chemical Structure
  28. GC11318 Rosiglitazone maleate A PPARγ agonist Rosiglitazone maleate Chemical Structure
  29. GC48059 Rosiglitazone-d3 An internal standard for the quantification of rosiglitazone Rosiglitazone-d3 Chemical Structure
  30. GC12431 RSL3

    Glutathione peroxidase 4 inhibitor

     RSL3 Chemical Structure
  31. GC13968 SB202190 (FHPI) SB202190 (FHPI) is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB202190 (FHPI) Chemical Structure
  32. GC10585 Simvastatin (Zocor) Simvastatin (Zocor) (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Simvastatin (Zocor) Chemical Structure
  33. GC13083 Siramesine Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity. Siramesine Chemical Structure
  34. GC44893 Siramesine (fumarate) Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM). Siramesine (fumarate) Chemical Structure
  35. GC15222 Siramesine hydrochloride

    Sigma-2 receptor agonist

     Siramesine hydrochloride Chemical Structure
  36. GC17369 Sorafenib

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

     Sorafenib Chemical Structure
  37. GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib Sorafenib (D3) Chemical Structure
  38. GC37665 Sorafenib (D4) Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4) Chemical Structure
  39. GC40922 SRS11-92 SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1. SRS11-92 Chemical Structure
  40. GC44947 SRS16-86 A ferroptosis inhibitor SRS16-86 Chemical Structure
  41. GC16868 Sulfasalazine NF-κB activation inhibitor Sulfasalazine Chemical Structure
  42. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma. TBHQ (tert-Butylhydroquinone) Chemical Structure
  43. GN10289 Trigonelline Trigonelline Chemical Structure
  44. GC15272 Troglitazone Selective PPARγ agonist Troglitazone Chemical Structure
  45. GC19457 Trolox Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. Trolox Chemical Structure
  46. GC10451 U-73122 Inhibitor of phospholipase C, phospholipase A2, and 5-LO U-73122 Chemical Structure
  47. GC40193 UAMC-3203 UAMC-3203 is an inhibitor of ferroptosis that has an IC50 value of 10 nM for inhibition of erastin-induced ferroptosis in IMR-32 neuroblastoma cells. UAMC-3203 Chemical Structure
  48. GC34939 UAMC-3203 hydrochloride A ferroptosis inhibitor UAMC-3203 hydrochloride Chemical Structure
  49. GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities Ungeremine Chemical Structure
  50. GC30512 Vatiquinone (EPI-743) Vatiquinone (EPI-743) (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. Vatiquinone (EPI-743) Chemical Structure
  51. GC16733 Vildagliptin (LAF-237) A DPP-4 inhibitor Vildagliptin (LAF-237) Chemical Structure
  52. GC31492 Vildagliptin dihydrate (LAF237 dihydrate) Vildagliptin dihydrate (LAF237 dihydrate) (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate (LAF237 dihydrate) Chemical Structure
  53. GC10042 Vitamin E

    fat-soluble vitamin

     Vitamin E Chemical Structure
  54. GC17309 Withaferin A Prevents NF-κB activation by inhibiting activation of IKKβ Withaferin A Chemical Structure
  55. GC70157 YL-939

    YL-939 is an effective inhibitor of ferroptosis. YL-939 inhibits ferroptosis by targeting PHB2/ferritin/iron axis.

     YL-939 Chemical Structure
  56. GC16014 Zileuton

    5-lipoxygenase (5-LOX) inhibitor, orally active

     Zileuton Chemical Structure

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