Ferroptosis

Acetylcysteine is an N-acetyl derivative of L-cysteine and a glutathione precursor with mucolytic activity.

Deferasirox is an orally active iron chelator used to treat iron overload diseases.

GKT137831, an orally dual NADPH oxidase 1/4 (NOX1/NOX4) inhibitor with potency in the submicromolar range, could prevent oxidative stress in human aortic endothelial cells induced by hyperglycemia and attenuate the development of atherosclerosis in diabetic mice.

Cisplatin, a platinum-containing anticancer drug, is one of the most commonly used cytotoxic agents for the treatment of a variety of solid malignant tumors.

A re-activator of the apoptotic function of mutant p53 proteins

Used to elute GST from glutathione agarose

PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1.

RSL3, a GPX4 inhibitor, triggers lipid peroxidation and decreases GPX4 expression.

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).

Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.

FG-4592 (ASP1517) is an oral bioavailable hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stimulates erythropoiesis.

Deferoxamine mesylate is an iron chelator that binds Fe(III) and many other metal cations.

SB 202190 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively.

An HMG-CoA reductase inhibitor

(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis.

Pravastatin sodium is a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC 50 of 5.6μM. Pravastatin sodium is commonly used in the research of hypercholesterolemia and various cardiovascular diseases.

Hemin chloride, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles.

A yellow pigment with diverse biological activities

A potent DPP-4 inhibitor

Pioglitazone belongs to the class of glitazones or thiazolidinediones, a series of oral anti-diabetic drugs.

Siramesine hydrochloride is an effective sigma-2 receptor agonist. Siramesine has an annanometer-level affinity for the sigma-2 receptor (IC 50 = 0.12nM), and its selectivity for the sigma-2 receptor is 140 times that of the sigma-1 receptor (IC 50 = 17nM).

Troglitazone is an orally active agonist of the peroxisome proliferator-activated receptor γ (PPARγ), with EC 50 values of 550nM and 780nM for human and murine receptors, respectively.

iron chelator and anticancer agent