Ferroptosis

Vatiquinone (EPI-743) (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases.

L-Glutamic acid monosodium salt (Monosodium glutamate) acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Vildagliptin dihydrate (LAF237 dihydrate) (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells.

Docebenone (AA 861) (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

An inducer of non-apoptotic cell death; YAP1 (YES related protein 1) targeted inhibitor

CDDO-Im (RTA-403) is a synthetic triterpenoid that activates Nuclear factor erythroid 2–related factor 2 (Nrf2) signaling by binding to Kelch-like ECH-associated protein 1 (Keap1), thereby inhibiting Nrf2 degradation and increasing its protein levels.

D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine) is a glutathione synthesis inhibitor.

Rehmannioside A is an inhibitor of cytochrome P450 enzymes (CYP3A4, 2C9, and 2D6), with IC 50 values of 10.08, 12.62, and 16.43μM, respectively.

A reduced form of NADP +

TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions.

NADPH tetrasodium salt is a sodium salt form of reduced nicotinamide adenine dinucleotide phosphate (NADPH), which is an essential cofactor in cells and acts as an electron donor.

Brusatol is an Nrf2 inhibitor isolated from Brucea javanica and exhibits significant tumor inhibition in multiple cancers through decreased resistance to cancer oxidative stress injury.

A ferroptosis inhibitor

(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae).

An antimalarial agent

A flavonoid with diverse biological activities

DL-Glutamine is used for biochemical research and drug synthesis.

Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.

An internal standard for the quantification of sorafenib

Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.