PI3K/Akt/mTOR Signaling
Research Areas
Products Related to PI3K/Akt/mTOR Signaling(719)
- GC30056Danthron (Dantron)CAS: 117-10-2Purity: >98.50%
Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK.
- GC30156Brevianamide F (Cyclo(L-Pro-L-Trp))CAS: 38136-70-8Purity: >98.00%
Brevianamide F (Cyclo(L-Pro-L-Trp)) (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity.
- GC30777PI4KIIIbeta-IN-10CAS: 1881233-39-1Purity: >99.50%
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.
- GC31536N-Oleoyl glycineCAS: 2601-90-3Purity: >98.00%
A putative substrate for peptidyl glycine αamidating enzyme
- GC31666Seletalisib (UCB5857)CAS: 1362850-20-1Purity: >98.50%
Seletalisib (UCB5857) (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.
- GC31751PI3Kδ-IN-2CAS: 1702816-75-8Purity: >99.50%
PI3Kδ-IN-2 (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM.
- GC32163BQR-695 (NVP-BQR695)CAS: 1513879-21-4Purity: >99.50%
BQR-695 (NVP-BQR695) is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
- GC32199T-00127_HEV1CAS: 900874-91-1Purity: >98.00%
T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM.
- GC32510Loureirin ACAS: 119425-89-7Purity: >99.50%
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
- GC32710GDC-0077 (RG6114)CAS: 2060571-02-8Purity: >99.00%
GDC-0077 (RG6114) is a potent and selective PI3Kα inhibitor with an IC 50 of 0.038nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC30056 | Danthron (Dantron) | 117-10-2 | >98.50% | |
Danthron (Dantron) is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron (Dantron) functions in regulating glucose and lipid metabolism by activating AMPK. | ||||
| GC30156 | Brevianamide F (Cyclo(L-Pro-L-Trp)) | 38136-70-8 | >98.00% | |
Brevianamide F (Cyclo(L-Pro-L-Trp)) (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. | ||||
| GC30229 | Cbz-B3A | 1884710-81-9 | >98% | |
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1). | ||||
| GC30582 | Crosstide | 171783-05-4 | >98% | |
Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. | ||||
| GC30770 | LM22B-10 | 342777-54-2 | >98.00% | |
An activator of TrkB and TrkC | ||||
| GC30777 | PI4KIIIbeta-IN-10 | 1881233-39-1 | >99.50% | |
PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM. | ||||
| GC30884 | LX2343 | 333745-53-2 | >99.50% | |
An inhibitor of BACE1 and PI3K | ||||
| GC31348 | 7-Methoxyisoflavone | 1621-56-3 | >99.50% | |
A synthetic isoflavone | ||||
| GC31361 | MK-3903 | 1219737-12-8 | >98.00% | |
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. | ||||
| GC31383 | Chitosan oligosaccharide COS | 148411-57-8 | >98.00% | |
| GC31411 | EX229 | 1219739-36-2 | >98.00% | |
EX229 is a benzimidazole derivative that functions as a potent allosteric agonist of AMP-activated protein kinase (AMPK). | ||||
| GC31470 | MK8722 | 1394371-71-1 | >98.00% | |
MK8722 is an orally allosteric pan-AMPK activator that supports glucose homeostasis, with EC 50 values of 1-60nM. | ||||
| GC31536 | N-Oleoyl glycine | 2601-90-3 | >98.00% | |
A putative substrate for peptidyl glycine αamidating enzyme | ||||
| GC31661 | APY0201 | 1232221-74-7 | >98.00% | |
APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. | ||||
| GC31666 | Seletalisib (UCB5857) | 1362850-20-1 | >98.50% | |
Seletalisib (UCB5857) (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM. | ||||
| GC31751 | PI3Kδ-IN-2 | 1702816-75-8 | >99.50% | |
PI3Kδ-IN-2 (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM. | ||||
| GC31756 | IPI-3063 | 1425043-73-7 | >98.50% | |
IPI-3063 is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5?±?1.2 nM. | ||||
| GC32118 | KDU691 | 1513879-19-0 | >99.50% | |
An antimalarial compound | ||||
| GC32163 | BQR-695 (NVP-BQR695) | 1513879-21-4 | >99.50% | |
BQR-695 (NVP-BQR695) is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively. | ||||
| GC32199 | T-00127_HEV1 | 900874-91-1 | >98.00% | |
T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM. | ||||
| GC32254 | Deltonin | 55659-75-1 | >99.50% | |
Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. | ||||
| GC32381 | BF738735 | 1436383-95-7 | >99.00% | |
BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM. | ||||
| GC32510 | Loureirin A | 119425-89-7 | >99.50% | |
Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. | ||||
| GC32710 | GDC-0077 (RG6114) | 2060571-02-8 | >99.00% | |
GDC-0077 (RG6114) is a potent and selective PI3Kα inhibitor with an IC 50 of 0.038nM. | ||||