PI3K/Akt/mTOR Signaling

IPI549 (IPI549) is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM. IPI549 shows >100-fold selectivity over other lipid and protein kinases.

LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.

O-304 is a small molecule AMPK activator.

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.

PQR309 is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33nM, 451nM, 661nM, 708nM and 89nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively.

SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

TGR-1202 is a PI3Kδ inhibitor, with IC50 and EC50 of 22.2 nM and 24.3 nM, respectively.

YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research.

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.

A potent and selective PI3Kδ inhibitor

A selective allosteric Akt1/Akt2 inhibitor

An essential fatty acid found in leafy green vegetables

Nimbolide is a triterpene derived from the leaves and flowers of Azadirachta indica L. Nimbolide inhibits NF- κ B induces tumor cell apoptosis. Nimbolide inhibited CDK4 / Cdk6 kinase activity. Nimbolide inhibits NF- κ B. Wnt, PI3K Akt, MAPK and JAK-STAT signaling pathways.

4-Vinylcyclohexene dioxide (VCD), a metabolite of 4-vinylcyclohexene (VCH), is synthesized in industries as an intermediate diluent for epoxy resins and other epoxides.

MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.

Miransertib (ARQ 092) HCl is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC 50 values of 2.7nM, 14nM, and 8.1nM for Akt1, Akt2, and Akt3, respectively.

MOTS-c is a mitochondrial-derived polypeptide with metabolic regulatory functions.

Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.

WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.

TMPA, a Nur77 antagonist, prevents the binding of Nur77 and LKB1 as well as stimulates LKB1 transport to the cytosol and phosphorylation.