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GSK-3

GSK3 (glycogen synthase kinase-3) is a serine/threonine protein kinase which contributes to cell survival, diabetes, insulin resistance and Alzheimer's diseases.

Products for  GSK-3

  1. Cat.No. Product Name Information
  2. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. (E/Z)-GSK-3β inhibitor 1  Chemical Structure
  3. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone  Chemical Structure
  4. GC14306 3F8 GSK-3β inhibitor 3F8  Chemical Structure
  5. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime  Chemical Structure
  6. GC39152 9-ING-41 9-ING-41 is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic drugs. 9-ING-41  Chemical Structure
  7. GC10336 A 1070722 GSK-3 inhibitor A 1070722  Chemical Structure
  8. GC15841 Alsterpaullone CDKs and GSK3β inhibitor Alsterpaullone  Chemical Structure
  9. GC15425 AR-A014418 A selective inhibitor of GSK3β AR-A014418  Chemical Structure
  10. GC16568 AZD1080 GSK3βinhibitor AZD1080  Chemical Structure
  11. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858  Chemical Structure
  12. GC10752 Bikinin

    GSK3 inhibitor and Brassinosteroid activator

    Bikinin  Chemical Structure
  13. GC14233 BIO-acetoxime

    GSK-3α/β inhibitor

    BIO-acetoxime  Chemical Structure
  14. GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP-135  Chemical Structure
  15. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research. BRD0705  Chemical Structure
  16. GC62875 BRD3731 BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731  Chemical Structure
  17. GC15642 CHIR 99021 trihydrochloride Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride  Chemical Structure
  18. GC12176 CHIR-98014 GSK-3β inhibitor,selective and ATP-competitive CHIR-98014  Chemical Structure
  19. GC16702 CHIR-99021 (CT99021)

    A selective GSK3 inhibitor

    CHIR-99021 (CT99021)  Chemical Structure
  20. GC17153 CHIR-99021 (CT99021) HCl Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl  Chemical Structure
  21. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride)  Chemical Structure
  22. GC49392 CHIR98024 A GSK3 inhibitor CHIR98024  Chemical Structure
  23. GC13176 CP21R7 GSK3β inhibitor CP21R7  Chemical Structure
  24. GC17690 Cromolyn sodium Mast cell membrane stabilizer Cromolyn sodium  Chemical Structure
  25. GC38330 EHT 5372 EHT 5372  Chemical Structure
  26. GC17457 FRATide GSK-3 inhibitor FRATide  Chemical Structure
  27. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877  Chemical Structure
  28. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1  Chemical Structure
  29. GC14987 GSK-3 Inhibitor IX (BIO) GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO)  Chemical Structure
  30. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1  Chemical Structure
  31. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11  Chemical Structure
  32. GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia. GSK-3β inhibitor 3  Chemical Structure
  33. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1  Chemical Structure
  34. GC16187 GSK-3β Inhibitor II GSK-3β inhibitor GSK-3β Inhibitor II  Chemical Structure
  35. GC43790 GSK3 Inhibitor XIII GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 μM. GSK3 Inhibitor XIII  Chemical Structure
  36. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1  Chemical Structure
  37. GC18810 GSK3β Inhibitor XI GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM). GSK3β Inhibitor XI  Chemical Structure
  38. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer. hSMG-1 inhibitor 11j  Chemical Structure
  39. GC16617 IM-12 GSK-3β inhibitor, potent IM-12  Chemical Structure
  40. GC12975 Indirubin A cyclin-dependent kinases and GSK-3β inhibitor Indirubin  Chemical Structure
  41. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime  Chemical Structure
  42. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid  Chemical Structure
  43. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate  Chemical Structure
  44. GC14182 Kenpaullone CDK1/cyclin B and GSK-3β inhibitor Kenpaullone  Chemical Structure
  45. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts  Chemical Structure
  46. GC17187 LY2090314 A potent and selective inhibitor of GSK3 LY2090314  Chemical Structure
  47. GC63446 PF-04802367 PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367  Chemical Structure
  48. GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase [1]. PF-07104091  Chemical Structure
  49. GC62661 PF-07104091 hydrate PF-07104091 hydrate  Chemical Structure
  50. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA  Chemical Structure
  51. GC37522 RGB-286638 A multi-kinase inhibitor RGB-286638  Chemical Structure
  52. GC37523 RGB-286638 free base A multi-kinase inhibitor RGB-286638 free base  Chemical Structure
  53. GC63181 SAR502250 SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250  Chemical Structure
  54. GC10463 SB 216763

    SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive IC50 of 34.3 nM[1-3].

    SB 216763  Chemical Structure
  55. GC13028 SB 415286 A selective inhibitor of GSK-3 SB 415286  Chemical Structure
  56. GC13576 TC-G 24

    GSK-3β inhibitor

    TC-G 24  Chemical Structure
  57. GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation TCS 183  Chemical Structure
  58. GC11515 TCS 184 Scrambled control peptide for use with TCS 183 TCS 184  Chemical Structure
  59. GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS 2002  Chemical Structure
  60. GC16584 TCS 21311 A JAK3 inhibitor TCS 21311  Chemical Structure
  61. GC14840 TDZD-8 GSK-3β inhibitor TDZD-8  Chemical Structure
  62. GC14465 Tideglusib non-ATP-competitive GSK-3β inhibitor Tideglusib  Chemical Structure
  63. GC17868 TWS119

    GSK-3β inhibitor

    TWS119  Chemical Structure
  64. GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15  Chemical Structure
  65. GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide  Chemical Structure
  66. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064  Chemical Structure

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