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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> GSK-3

GSK-3

GSK3 (glycogen synthase kinase-3) is a serine/threonine protein kinase which contributes to cell survival, diabetes, insulin resistance and Alzheimer's diseases.

Products for  GSK-3

  1. Cat.No. Product Name Information
  2. GC62736 (E/Z)-GSK-3β inhibitor 1 (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. (E/Z)-GSK-3β inhibitor 1 Chemical Structure
  3. GC74261 (R)-(+)-O-Demethylbuchenavianine (R)-(+)-O-Demetlbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK). (R)-(+)-O-Demethylbuchenavianine Chemical Structure
  4. GC13907 1-Azakenpaullone GSK-3β inhibitor,potent and selective,cell-permeable 1-Azakenpaullone Chemical Structure
  5. GC14306 3F8 GSK-3β inhibitor 3F8 Chemical Structure
  6. GC35162 5-Iodo-indirubin-3'-monoxime 5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively. 5-Iodo-indirubin-3'-monoxime Chemical Structure
  7. GC70708 6-Me-ATP trisodium 6-Me-ATP (N6-Methyl-ATP) trisodium is a N6-modified ATP derivative. 6-Me-ATP trisodium Chemical Structure
  8. GC39152 9-ING-41

    Elraglusib

     9-ING-41 is a selective and potent GSK-3β inhibitor with an IC50 value of 0.71μM. 9-ING-41 Chemical Structure
  9. GC10336 A 1070722 GSK-3 inhibitor A 1070722 Chemical Structure
  10. GC68592 ABC1183

    ABC1183 is a selective dual inhibitor of GSK3 and CDK9 with oral activity. Its IC50 values for GSK3β, GSK3α, and CDK9/cyclin T1 are 657 nM, 327 nM, and 321 nM respectively. ABC1183 has anti-inflammatory properties as well as anti-tumor activity.

     ABC1183 Chemical Structure
  11. GC15841 Alsterpaullone

    9-Nitropaullone,NSC 705701

     CDKs and GSK3β inhibitor Alsterpaullone Chemical Structure
  12. GC15425 AR-A014418

    AR-AO 14418;AR 0133418;AR 014418;GSK 3β inhibitor

     A selective inhibitor of GSK3β AR-A014418 Chemical Structure
  13. GC16568 AZD1080 GSK3βinhibitor AZD1080 Chemical Structure
  14. GC14736 AZD2858 GSK-3 inhibitor,potent and selective AZD2858 Chemical Structure
  15. GC10752 Bikinin

    Abrasin

     Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3 (glycogen synthase kinase 3)/Shaggy-like kinases. Bikinin Chemical Structure
  16. GC14233 BIO-acetoxime

    6-Bromoindirubin-3'-acetoxime, GSK3 Inhibitor X

    GSK-3α/β inhibitor

     BIO-acetoxime Chemical Structure
  17. GC38892 BIP-135 BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP-135 Chemical Structure
  18. GC68802 BRD0209

    BRD0209 is an effective, selective, and dual inhibitor of GSK3α/β (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). It is also a reversible ATP-competitive inhibitor with fast kinetics (Ki values of 4.2 nM for both isoforms). BRD0209 is a tricyclic pyrazolone-fused tetrahydroquinoline compound. It has potential in researching mood disorders.

     BRD0209 Chemical Structure
  19. GC39181 BRD0705 BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research. BRD0705 Chemical Structure
  20. GC62875 BRD3731 BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 Chemical Structure
  21. GC73183 CDK8-IN-12 CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 Chemical Structure
  22. GC15642 CHIR 99021 trihydrochloride

    CHIR-99021 trihydrochloride; CT99021 trihydrochloride

     Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy. CHIR 99021 trihydrochloride Chemical Structure
  23. GC12176 CHIR-98014 CHIR-98014 is a potent, cell-permeable inhibitor of GSK-3α and GSK-3β with IC50 values of 0.65nM and 0.58nM, respectively. CHIR-98014 Chemical Structure
  24. GC16702 CHIR-99021 (CT99021)

    CHIR99021, CHIR-99021, CHIR 99021, CT99021,GSK-3 Inhibitor XVI

     CHIR-99021 (CT99021) is a kind of highly selective inhibitor of GSK-3, the IC50 values for GSK-3α and GSK-3β are 10nM and 6.7nM respectively. CHIR-99021 (CT99021) Chemical Structure
  25. GC17153 CHIR-99021 (CT99021) HCl

    CHIR-99021 monohydrochloride; CT99021 monohydrochloride

     Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 (CT99021) HCl induces autophagy. CHIR-99021 (CT99021) HCl Chemical Structure
  26. GC32942 CHIR-99021 monohydrochloride (CT99021 monohydrochloride) CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Chemical Structure
  27. GC49392 CHIR98024

    CT 98024

     A GSK3 inhibitor CHIR98024 Chemical Structure
  28. GC13176 CP21R7 GSK3β inhibitor CP21R7 Chemical Structure
  29. GC17690 Cromolyn sodium Mast cell membrane stabilizer Cromolyn sodium Chemical Structure
  30. GC38330 EHT 5372 EHT 5372 Chemical Structure
  31. GC17457 FRATide

    GSK-3 inhibitor

     FRATide Chemical Structure
  32. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877 Chemical Structure
  33. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1 Chemical Structure
  34. GC14987 GSK-3 Inhibitor IX (BIO)

    GSK-3 Inhibitor IX

     GSK-3 Inhibitor IX (BIO) is a potent, selective and reversible inhibitor of glycogen synthase kinase-3 (GSK-3) with an IC50 value of 5nM for GSK-3α/β. GSK-3 Inhibitor IX (BIO) Chemical Structure
  35. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1 Chemical Structure
  36. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11 Chemical Structure
  37. GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia. GSK-3β inhibitor 3 Chemical Structure
  38. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 Chemical Structure
  39. GC16187 GSK-3β Inhibitor II

    Tip-oxadiazole

     GSK-3β inhibitor GSK-3β Inhibitor II Chemical Structure
  40. GC43790 GSK3 Inhibitor XIII

    Glycogen Synthase Kinase 3 Inhibitor XIII

     GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 μM. GSK3 Inhibitor XIII Chemical Structure
  41. GC69196 GSK3 Substrate, α, β subunit

    GSK3 Substrate, α, β subunit is a peptide substrate of glycogen synthase kinase-3 (GSK-3) that can be used to measure GSK-3 activity.

     GSK3 Substrate, α, β subunit Chemical Structure
  42. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1 Chemical Structure
  43. GC69195 GSK3-IN-3

    GSK3-IN-3 is a mitophagy inducer that can induce Parkin-dependent mitochondrial autophagy. It is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 has non-ATP and non-substrate competitive properties and has neuroprotective effects on 6-OHDA.

     GSK3-IN-3 Chemical Structure
  44. GC18810 GSK3β Inhibitor XI

    GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM).

     GSK3β Inhibitor XI Chemical Structure
  45. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 value of 0.11nM. hSMG-1 inhibitor 11j Chemical Structure
  46. GC72931 HTH-01-091 TFA HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 TFA Chemical Structure
  47. GC16617 IM-12

    GSK3β Inhibitor XIX

     GSK-3β inhibitor, potent IM-12 Chemical Structure
  48. GC12975 Indirubin

    C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327

     Indirubin is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC50: 50-100nmol/L) and glycogen synthase kinase-3beta (GSK-3β) (IC50: 5-50nmol/L), with oral administration characteristics. Indirubin Chemical Structure
  49. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime Chemical Structure
  50. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid Chemical Structure
  51. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate Chemical Structure
  52. GC14182 Kenpaullone

    9Bromopaullone, NSC 664704

     CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  53. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts Chemical Structure
  54. GC17187 LY2090314

    LY 2090314;LY-2090314

     A potent and selective inhibitor of GSK3 LY2090314 Chemical Structure
  55. GC63446 PF-04802367

    PF-367

     PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 Chemical Structure
  56. GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase PF-07104091 Chemical Structure
  57. GC62661 PF-07104091 hydrate PF-07104091 hydrate is a potent and selective inhibitor of CDK2/E1 and GSK3β with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has antitumor activity against cyclin E1-amplified cancers and is commonly used to treat HR+/HER2- breast cancer and ovarian cancer PF-07104091 hydrate Chemical Structure
  58. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA Chemical Structure
  59. GC37522 RGB-286638 A multi-kinase inhibitor RGB-286638 Chemical Structure
  60. GC37523 RGB-286638 free base A multi-kinase inhibitor RGB-286638 free base Chemical Structure
  61. GC63181 SAR502250 SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 Chemical Structure
  62. GC10463 SB 216763

    SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive IC50 of 34.3 nM[1-3].

     SB 216763 Chemical Structure
  63. GC13028 SB 415286 A selective inhibitor of GSK-3 SB 415286 Chemical Structure
  64. GC73063 Tagtociclib hydrate

    PF-07104091 hydrate

     PF-07104091 drate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. Tagtociclib hydrate Chemical Structure
  65. GC13576 TC-G 24

    GSK-3β inhibitor

     TC-G 24 Chemical Structure
  66. GC10440 TCS 183 competitive inhibitor of GSK-3β (Ser9) phosphorylation TCS 183 Chemical Structure
  67. GC11515 TCS 184 Scrambled control peptide for use with TCS 183 TCS 184 Chemical Structure
  68. GC11627 TCS 2002 TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS 2002 Chemical Structure
  69. GC16584 TCS 21311

    NIBR3049

     A JAK3 inhibitor TCS 21311 Chemical Structure
  70. GC14840 TDZD-8

    GSK3β Inhibitor I, NP 01139

     GSK-3β inhibitor TDZD-8 Chemical Structure
  71. GC14465 Tideglusib

    NP031112

     Tideglusib is a potent, selective, and irreversible non-ATP competitive glycogen synthase kinase-3 (GSK-3) inhibitor. The IC50 values for GSK-3βWT and GSK-3βC199A are 5nM and 60nM, respectively. Tideglusib Chemical Structure
  72. GC17868 TWS119 TWS119 is a highly potent and selective inhibitor of glycogen synthase kinase-3β (GSK-3) with KD value of 126nM and IC50 value of 30nM. TWS119 Chemical Structure
  73. GC37923 VP3.15 VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 Chemical Structure
  74. GC37924 VP3.15 dihydrobromide VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide Chemical Structure
  75. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM. WAY-119064 Chemical Structure

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